iiinova — where your digital self keeps evolving

Irene Cantone @cantoneirene.bsky.social · 22/07/2026

📢 #Postdoc job: I am looking for a #bioinformatician to join my lab for investigating #XchromosomeInactivation and #chromatin-mediated #epigenetic mechanisms underlying #sexbias in #MultipleSclerosis. Please RT

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Marieke Oudelaar @mariekeoudelaar.bsky.social · 07/07/2026

We are looking for someone to lead the new Facility for Protein Biochemistry & Biophysics at the MPI of Immunobiology and Epigenetics in Freiburg — please spread the word and apply if you are interested!

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Nature @nature.com · 25/06/2026

For the second time this month, a team of researchers has reported harnessing a precise gene-editing technique to alter the DNA of human embryos go.nature.com/4vwIXrO

go.nature.com

‘Edited’ human embryos reveal secrets of our development — and fuel ethical debate

Ethical discussions are urgently needed as genome-editing science advances, some researchers say.

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Irene Cantone @cantoneirene.bsky.social · 11/06/2026

#postdoc #fellowship available in my lab (1year renewable) to investigate #chromatin mediated #epigenetic mechanisms of #sexbias in #autoimmunity and the role of long #mcRNA #XIST. Please RT!

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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 23/04/2026

📖 The final version of our paper is out in press Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption authors.elsevier.com/a/1m%7EU03vV... or www.cell.com/molecular-ce...

cell.com

Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption

Shah, Tortora, et al. show that cells can dial the rate of cohesin loop extrusion by balancing the relative dosage of NIPBL and PDS5. Their models provide a quantitative mechanistic basis for the gene...

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Maxim Greenberg @maxvcg.bsky.social · 01/05/2026

This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...

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Grand Lab @grandlab.bsky.social · 07/05/2026

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

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Springer Nature @springernature.com · 16/04/2026

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to. spklr.io/63324EJmf0

spklr.io

Person functionally cured of HIV after bone marrow transplant from sibling

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to

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Emmanuel Cazottes @manucazottes.bsky.social · 28/01/2026

Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇

science.org

Remodeling of XIST regulatory landscape during primate evolution

How gene regulation strategies rapidly evolve across short evolutionary timescales is explored.

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Duncan Sproul @sproullab.bsky.social · 12/12/2025

Last few days to apply for this #PhD project!

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Kelly @broadwaybabyto.bsky.social · 27/11/2025

Australia recorded ZERO cases of cervical cancer in women under 25 for the first time since they started tracking the cancer in the 80s. This is the power of vaccines. The HPV vaccine is extremely effective at preventing cancer. Viruses can be oncogenic. Get your vaccines and protect yourself!

www1.racgp.org.au

newsGP - Australia set for world-first cervical cancer elimination

Vaccination programs have played a key role, and GPs remain ‘instrumental’ in boosting screening rates to reach the 2035 target.

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Duncan Sproul @sproullab.bsky.social · 25/11/2025

🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease? Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city. 🧵 1/4 Please repost 🙏

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Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · 30/10/2025

Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!

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Irene Cantone @cantoneirene.bsky.social · 13/10/2025

Advice needed: can you distinguish splicing variants by commercial #spatialtranscriptomic (eg visium)? #singlecell #omics

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Irene Cantone @cantoneirene.bsky.social · 09/10/2025

The #Nobel prize has been assigned to the discovery of #Treg peripheral tolerance. We are humbly greatful for this discovery as we recently described a subtype of Tregs associated with worse breast cancer prognosis

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bioRxivpreprint @biorxivpreprint.bsky.social · 08/10/2025

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism www.biorxiv.org/content/10.1101/202…

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Sheila Teves @sheilateves.bsky.social · 07/10/2025

How does a “universal” transcription factor evolve to do species-specific jobs? Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes. Read it here 👉 www.biorxiv.org/content/10.1... #MolecularEvolution #Transcription

biorxiv.org

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

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University of Cambridge @cam.ac.uk · 07/10/2025

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: bit.ly/4mM8o3r

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David Katz @katzlab.bsky.social · 07/10/2025

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Irene Cantone @cantoneirene.bsky.social · 03/10/2025

#Xcromosome paper on the role of the #human specific long noncoding RNA #XACT!

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bioRxivpreprint @biorxivpreprint.bsky.social · 03/10/2025

Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression www.biorxiv.org/content/10.1101/202…

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Kate Cavanaugh @katecavanaugh.bsky.social · 01/10/2025

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

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Jamie Hackett @jamiehackett.bsky.social · 27/09/2025

❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....

embopress.org

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

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Irene Cantone @cantoneirene.bsky.social · 10/04/2025

To the #XchromosomeInactivation field: anyone knows Xist is a long #noncodingRNA Which publication has ruled out that there are protein coding regions within it? And how?

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Irene Cantone @cantoneirene.bsky.social · 12/04/2024

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

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Irene Cantone @cantoneirene.bsky.social · 08/03/2025

The story of sex determination from a woman’s life perspective. Beautiful thread for #WomenInternationalDay

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Mike Schatz @mikeschatz.bsky.social · 08/03/2025

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

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Irene Cantone @cantoneirene.bsky.social · 07/03/2025

A #computational #Postdoc position is available in my lab to dive into #chromatin mediated #epigenetic mechanisms underlying #autoimmune reactions in #MultipleSclerosis! Please circulate

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Miguel Branco @brancolab.bsky.social · 21/01/2025

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

qmul-jobs.tal.net

Postdoctoral Research Associate - QMUL Jobs

ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:

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Davide Mazza @davidemazza.bsky.social · 20/12/2024

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

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Antoine Zalc @antoinezalc.bsky.social · 19/12/2024

🚨🚨🚨 Call is now open!!! Deadline approaching... Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities APPLY 👇👇👇👇👇

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Aurora Ruiz-Herrera @aruizherrera.bsky.social · 01/12/2024

🎯Spotlight by @ProfJennyGraves on imprinting of the paternal marsupial X chromosome by DNA methylation 👉https://sciencedirect.com/science/article/pii/S0168952524002622 highlighting our recent paper on X chromosome inactivation in marsupials 👉https://www.pnas.org/doi/abs/10.1073/pnas.2412185121

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Sheila Teves @sheilateves.bsky.social · 30/11/2024

🎉Excited to share our new preprint on Biorxiv 🥳 We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress! So what did we find? 🧵 www.biorxiv.org/content/10.1...

biorxiv.org

Dynamic regulation of RNA Polymerase III transcription in mouse embryonic stem cells during heat shock stress

Cells respond to many different types of stresses by overhauling gene expression patterns, both at the transcriptional and translational level. Under heat stress, global transcription and translation ...

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The Groth lab @grothlab.bsky.social · 26/11/2024

Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN

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Michelle Percharde @mpercharde.bsky.social · 26/11/2024

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

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Irene Cantone @cantoneirene.bsky.social · 13/09/2024

We did it! We biorxived a manuscript!!! First from my lab in which we show that a subset of #Treg expressing a splicing variant of #FOXP3 differing for 105bp exon are enriched in #breastcancer tumors with worse prognosis related with immune suppressive capacity www.biorxiv.org/content/10.1...

biorxiv.org

CD4+Foxp3E2+ regulatory T cell frequency predicts breast cancer prognosis and recurrence

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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Irene Cantone @cantoneirene.bsky.social · 11/06/2024

I must be producing a lot of em on grant deadline … ?

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Sandra Laurentino @sandralaurentino.bsky.social · 10/06/2024

Funny annecdote about the publication of Darwin's "On the origin of species". Over 150 years later it feels like peer-review didn't change all that much. www.nytimes.com/2024/06/09/b...

His publisher toyed with changing the book’s title (he preferred “The Origin: Natural Selection”), and one peer reviewer suggested that Darwin drop all the evolution stuff and expand the chapter on raising pigeons. (“Everybody is interested in pigeons,” the reviewer explained.) Darwin demurred.

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Irene Cantone @cantoneirene.bsky.social · 16/05/2024

Looking for 1 year Postdoc in #chromatin regulation of #transcription for #XChromosomeInactivation study in human #iPSC/lymmphocytes (collaborative project!) wet lab/hybrid. Candidate needing #VISA might be supported only if competitive for #fellowships. Start:October 2024

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eric lai @lucksmith.bsky.social · 04/05/2024

may the 4th be with you!!

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