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Brian Plosky

@brianplosky.bsky.social
280 followers 277 following 93 posts

Runner, cyclist, scientific publications at Arc Institute. Formerly EiC at Mol Cell. Opinions are mine.

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Reposted by Brian Plosky
Antoine Zalc @antoinezalc.bsky.social · 24/09/2026
inpreparation.substack.com/p/opinion-re...
inpreparation.substack.com
Opinion: I Miss When The NIH Payline Was 40% And We All Mouth-Pipetted Phenol
By Dr. Douglas R. Waverly, Professor Emeritus of Biochemistry, Yale University
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Koreen Brennan @koreen.bsky.social · 15/04/2026
France passed a law requiring solar panels on every parking lot with more than 80 spaces. Equals 10 nuclear reactors Reduces heat island, shades cars The US -- 800 million parking spaces. Most of them are uncovered asphalt sitting in direct sunlight. Why aren't we doing this?
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Brian Plosky @brianplosky.bsky.social · 01/07/2026
Maybe there are some AI x Bio people on bluesky??
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Brian Plosky @brianplosky.bsky.social · 24/06/2026
“One recent survey found that about 30 percent of the people who tracked their sleep were at risk of orthosomnia, an unhealthy fixation with getting perfect sleep.” www.nytimes.com/2026/06/24/w... (gift link)
nytimes.com
The Wearable Data Your Doctor Actually Wants
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Brian Plosky @brianplosky.bsky.social · 23/06/2026
This seems like the kind of integration across models and the type of interface needed to make these generative models generally useful
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Julius Brennecke @juliusbrennecke.bsky.social · 13/06/2026
a small attempt to capture this enormous loss and what Greg meant and means to so many. www.cell.com/cell/fulltex...
cell.com
Gregory J. Hannon (1964–2026)
Gregory J. Hannon passed away in April 2026 at the age of 61. A towering figure in modern molecular biology, Greg influenced remarkably diverse areas of science. His work reshaped our understanding of...
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Jason Moore @moorejh.bsky.social · 03/05/2026
#dna #captcha
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Arc Institute @arcinstitute.org · 16/04/2026
mTOR inhibitors stop cancer cells from dividing, but they rarely kill them. New work in Molecular Cell from Luke Gilbert & lab reveals a mechanism connecting mTOR signaling, cholesterol biology, and ferroptosis that could turn growth arrest into cancer cell death.
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Arc Institute @arcinstitute.org · 14/04/2026
For decades, we’ve known that the ENPP1 K173Q variant raises type 2 diabetes risk, but not why. New work from @songnanwang.bsky.social in @lingyinli.bsky.social's lab, in collaboration with @svenssonlab.bsky.social, shows that this variant may promote metabolic dysfunction in brown adipose tissue.
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openRxiv @openrxiv.bsky.social · 25/03/2026
The latest edition of Re:Port is live! Check it out and make sure to subscribe to get the latest updates from openRxiv right to your inbox. openrxiv.org/wp-content/u...
openrxiv.org
openRxiv's Re:Port Newsletter | Issue 2
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Brian Plosky @brianplosky.bsky.social · 20/03/2026
Thanks for the chance to contribute!
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Eric Topol @erictopol.bsky.social · 20/03/2026
AI to understand the language of life. Our review just published nature.com/articles/s41... Free access rdcu.be/e89lQ
nature.com
Generalist biological artificial intelligence in modeling the language of life - Nature Biotechnology
This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across bi...
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Brian Plosky @brianplosky.bsky.social · 20/03/2026
Happy to have played a part in putting this together. It was definitely interesting to see what the model proposed for Evo-designed proteins from @brianhie.bsky.social‘s lab.
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Brian Plosky @brianplosky.bsky.social · 20/03/2026
Thanks for the chance to contribute to this!
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Reposted by Brian Plosky
Gladstone Institutes @gladstoneinst.bsky.social · 15/03/2026
Gladstone researchers found that low-oxygen conditions cause red blood cells to act like “glucose sponges,” lowering blood sugar.
sciencefocus.com
Why people living at higher altitudes are less prone to diabetes | BBC Science Focus Magazine
The lack of oxygen at high altitudes triggers red blood cells to soak up more oxygen, reducing the risk of diabetes
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Arc Institute @arcinstitute.org · 14/03/2026
Arc Co-Founder and Executive Director Silvana Konermann is speaking at TED2026 in Vancouver (April 13-17). She'll be sharing her vision for Arc's Virtual Cell Initiative, recently announced as part of The Audacious Project's 2025 cohort, on one of the world's biggest stages.
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Thiago Carvalho @cyrilpedia.bsky.social · 13/03/2026
I love a good high-altitude adaptation story: "Therefore, we hypothesized that RBCs represent the primary glucose sink under hypoxic conditions (...) These findings uncover an unexpected yet fundamental role for RBCs in systemic glucose homeostasis, opening new avenues for diabetes therapies."
cell.com
Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude
Martí-Mateos et al. show that red blood cells explain improved glucose tolerance at high altitude. By manipulating red blood cell number, they determine that these cells are necessary and sufficient f...
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Angela Andersen @angelaandersen.bsky.social · 06/03/2026
The LSEF JEDI Award provides 10 hours of expert editorial support to scientists from groups underrepresented in science. Deadline: March 10. Please share broadly: lifescienceeditors.org/apply/
lifescienceeditors.org
Apply for a JEDI Award - Life Science Editors Foundation
“Before this backlash worsens, DEI advocates, the scientific community, universities, and federal agencies need to collectively call out the dangers of setting aside DEI and come up with robust ways t...
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Brian Plosky @brianplosky.bsky.social · 05/03/2026
With a year between preprint and publication, the publication milestone becomes a chance to reflect both on the additional validation added in revision and how the scientific community is using Evo 2 based on ~200 citations to the preprint & 10s of thousands of downloads of the model. Read more ⬇️
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Brian Plosky @brianplosky.bsky.social · 02/03/2026
This is very cool. I’m a bit worried about the use of “cookie elements” for what might be petri dishes. Maybe a lab safety problem?!?!?🙃
Image of a Lego lab bench from the Lego Ideas page. There appears to be 2 petri dishes that use round 1 X 1 Lego tiles with sprinkles, which are generally used as cookies in standard Lego sets.
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Sjors Scheres @sjorsscheres.bsky.social · 16/10/2025
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...
beta.ideas.lego.com
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
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Gladstone Institutes @gladstoneinst.bsky.social · 26/02/2026
🚨 🚨 NEW PUBLICATION 🚨 🚨 "Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease" @arcinstitute.org @ishahjain.bsky.social @cp-cell.bsky.social
bit.ly
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease
A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...
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Arc Institute @arcinstitute.org · 25/02/2026
Most drug discovery starts with a disease & searches for a cure. New research out in Cell from Arc investigator Isha Jain’s lab flips this model, starting with a potential cure (vitamins) & systematically identifying which diseases it could treat.
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Arc Institute @arcinstitute.org · 23/02/2026
A reminder that applications close Friday, Feb 27 for the Arc AIxBio Fellows Program. Undergrads: propose and run your own AI + biology research project over 6–12 months, with mentorship from Arc scientists. Apply solo or as a team of 2–3. arcinstitute.org/programs/aix...
arcinstitute.org
Arc AIxBio Fellows Program for Undergrads | Arc Institute
Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.
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Arc Institute @arcinstitute.org · 19/02/2026
People living at high altitude have better glucose tolerance & lower diabetes risk, but the mechanism behind why has remained a mystery. New research out in Cell Metabolism from Isha Jain's lab reveals an unexpected answer—red blood cells.
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Arc Institute @arcinstitute.org · 19/02/2026
Most genetic interaction studies measure gene relationships in one condition, but environment can reshape which genes depend on each other. Today in Molecular Cell, Luke Gilbert & team deliver the first systematic, multi-condition map of genetic rewiring in human cells.
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Arc Institute @arcinstitute.org · 19/02/2026
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder. Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
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Hani Goodarzi @genophoria.bsky.social · 10/02/2026
Amazing collaboration with the Jain lab! The impact of systemic hypoxia on cancer!
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Arc Institute @arcinstitute.org · 11/02/2026
In this Molecular Cell Voices piece, @genophoria.bsky.social comments on how he thinks about bridging bench and computational work: www.cell.com/molecular-ce...
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Arc Institute @arcinstitute.org · 05/02/2026
An amazing day for science at the 2nd Annual Arc Symposium! Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.
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Noam Teyssier @noamteyssier.bsky.social · 22/01/2026
Today I’m happy to release cyto, a tool I’ve developed at @arcinstitute.org to dramatically increase our computational throughput with 10x-flex single-cell processing by more than 16X!
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Arc Institute @arcinstitute.org · 23/01/2026
A new paper from Jeffrey Wang, @genophoria.bsky.social, and team describes orphan non-coding RNAs, known as "oncRNAs," as cancer-emergent molecules with important roles in tumor identity and progression, and clinical monitoring across human cancers: www.cell.com/cell-reports...
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Arc Institute @arcinstitute.org · 28/01/2026
In a new review published in @cp-neuron.bsky.social, @christophthaiss.bsky.social and team synthesize emerging research on intestinal interoception, highlighting how signals from the gut shape communication between the environment, the body, and the brain to maintain human health.
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Arc Institute @arcinstitute.org · 09/01/2026
Predicting cell state in previously unseen conditions has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly at inference time, no fine-tuning required.
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Arc Institute @arcinstitute.org · 05/01/2026
Today, we welcome Megan van Overbeek as our first Chief Scientific Officer. At Arc, she'll drive the discovery of novel therapeutic strategies for complex diseases, bringing expertise that bridges fundamental research with therapeutic development.
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bioRxiv & medRxiv @biorxiv-medrxiv.bsky.social · 18/12/2025
The @openRxiv.bsky.social team wishes all of our authors, readers, Affiliates and community members a very happy holiday season and turn of the year! Please excuse any delays in processing your submissions while our staff also enjoy some well-deserved time off ☃️ #preprints #biorxiv #medrxiv
Christmas card with a green background and a Zoom meeting screenshot with 12 members of the openRxiv team (top to bottom, left to right the name tags say: Tracy Teal, Olaya, Sam Hindle, Richard Sever, Gumdrop - Master Elf, Ted Roeder, Sol, Joanne McFadden, John Inglis, Martina, Josh Sinanan, Sanchari Ghosh). The text says "Happy Holidays from the openRxiv team."
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Brian Plosky @brianplosky.bsky.social · 17/12/2025
Don’t miss this opportunity! Please share with recent PhD grads or students who will soon graduate
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Brian Plosky @brianplosky.bsky.social · 14/12/2025
@nytimes.com why not?
Sunday, Dec 14th New York Time Spelling Bee puzzle rejecting the word “inviable” as a potential answer despite it being both a real word and a perfect pangram for today’s puzzle.
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Brian Plosky @brianplosky.bsky.social · 07/12/2025
Impressive! Clever approach.
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Brian Plosky @brianplosky.bsky.social · 07/12/2025
Congrats to the winners! I had an inside view of how the Arc team managed this competition since June. They were super-responsive to the competitors, handling questions and concerns in a transparent manner as they arose.while also doing their “day jobs”.
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Nature Methods @natmethods.nature.com · 18/11/2025
Nature Methods is hiring! We are looking for candidates with expertise in genetics, genomics and/or molecular biology to join our editorial team in the US (NYC/Jersey City) or China (Shanghai/Beijing). Apply by December 12! springernature.wd3.myworkdayjobs.com/SpringerNatu...
media.tenor.com
a sign that says we 're hiring in orange on a white background
ALT: a sign that says we 're hiring in orange on a white background
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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 11/11/2025
A true legend. www.bcm.edu/about-us/lea...
bcm.edu
In Memoriam: Bert W. O'Malley, M.D.
In Memoriam: Bert W. O'Malley, M.D....
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Arc Institute @arcinstitute.org · 06/11/2025
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
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Brian Plosky @brianplosky.bsky.social · 05/11/2025
Coincidental juxtaposition of SNARE with the wrong kind of SNAP in my other feed:
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Brian Plosky @brianplosky.bsky.social · 04/11/2025
Like the Monkey’s Paw—be careful what you wish for!
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Noam Teyssier @noamteyssier.bsky.social · 29/10/2025
I've updated the BINSEQ manuscript to stay up to date with changes since I originally put it out at the beginning of the year Some notable changes: 1. Support for ambiguous bases with 4bit encoding 2. Support for sequence headers 3. Improved API www.biorxiv.org/content/10.1...
biorxiv.org
BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences
Modern genomics produces billions of sequencing records per run, which are typically stored as gzip-compressed FASTQ files. While this format is widely used, it is not optimal for high-throughput proc...
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Arc Institute @arcinstitute.org · 29/10/2025
Welcome to our 9th Core Investigator and first physician-scientist, John Pluvinage. His team investigates the hidden overlap between autoimmunity and neurodegeneration, developing targeted treatments for mysterious neurological cases and common dementias.
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Arc Institute @arcinstitute.org · 24/10/2025
Arc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...
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Brian Plosky @brianplosky.bsky.social · 16/10/2025
Just tried this out on a couple of preprints, and this seems legit! Only minor issue so far is the Word file for the plan not opening. Also, it seems that AI x Bio is not a fully supported domain yet. But nice that it prominently acknowledged that!
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Arc Institute @arcinstitute.org · 09/10/2025
Hear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and Serge Saxonov: thebioreport.podbean.com/e/transformi...
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