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Philippe Bastin's Lab @bastinlab.bsky.social · 21/09/2026

Great start of the 14th meeting on cilia, flagella and centrosomes (CFC2026) in Aussois with exciting talks of Maya Sarieddine, Jérémy Vincent, Amandine Hecquet, Sarah de Freitas and Vincent Gache, with plenty of questions and debates! Looking forward to two more exciting days!

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Philippe Bastin's Lab @bastinlab.bsky.social · 27/07/2026

It's asymmetry of course, not symmetry!

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Philippe Bastin's Lab @bastinlab.bsky.social · 24/07/2026

There is more than cilia beating in the establishment of left-right symmetry! Proud to have contributed to this beautiful study by Amaia Ochandorena Saa @meilhacsigolene.bsky.social where Thierry Blisnick imaged mouse node by SEM doi/10.1126/sciadv.adx6486 @pasteur.fr @institutimagine.bsky.social

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Spyros Lytras @spyroslytras.bsky.social · 23/07/2026

Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!

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Philippe Bastin's Lab @bastinlab.bsky.social · 08/07/2026

Another long-term project finally completed! Solving (well we think) the contribution of the IFT-A complex in anterograde transport. www.biorxiv.org/content/10.6... Congratulations to Adeline Mallet, Thierry Blisnick, @ebertiaux.bsky.social, Cécile Fort, Manuel Majrouh and Sylvain Trépout!

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Philippe Bastin's Lab @bastinlab.bsky.social · 26/06/2026

So lucky to work with such a great and enthusiastic team 😀 Congratulations to all for insightful talks and lively discussions! Watch this space for the laureate of the best title...

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Philippe Bastin's Lab @bastinlab.bsky.social · 26/06/2026

Beautiful videos nicely explaining microtubules! Congratulations to Renaud Chabrier and Casten Janke 👍 www.youtube.com/watch?v=dVbv...

youtube.com

Microtubules | Scientific Animated Short Film 2026

YouTube video by Drawing Intelligence

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Melanie Bonhivers @mbonhivers.bsky.social · 12/06/2026

The CNRS has opened a Junior Professor Chair (CPJ) call in Parasitology, and the Microbiologie Fondamentale et Pathogénicité (MFP, Bordeaux) laboratory is among the potential host institutions. More information: www.insb.cnrs.fr/fr/cnrsinfo/... #Parasitology #Protozoology #ResearchJobs #CNRS

insb.cnrs.fr

Junior Professor Chairs (CPJ) 2026 – CNRS Biology

CNRS Biology is recruiting researchers through its Junior Professor Chair (CPJ) program, subject to final approval by the French Ministry of Higher Ed

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Development @dev-journal.bsky.social · 11/06/2026

Sigolène Meilhac @meilhacsigolene.bsky.social will be speaking on "Congenital structural heart defects" at our Journal Meeting in the UK this September #HumanDev26 Register to attend: biologists.com/meetings/dev... Abstract deadline: 12 June 2026

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Philippe Bastin's Lab @bastinlab.bsky.social · 11/06/2026

Even more striking, despite not swimming, they divide and grow normally, which seems to contradict the role of flagellum motility in cytokinesis. We propose a model based on flagellum length and attachment to explain this unexpected finding. Let us know what you think, feedback is welcome!

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Philippe Bastin's Lab @bastinlab.bsky.social · 11/06/2026

Strikingly, flagella are too short! They incorporate tubulin too slowly and fail to elongate beyond 7 µm. Furthermore they acquire the FLAM8 maturation marker too quickly and lose the locking protein CEP164C much faster!

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Philippe Bastin's Lab @bastinlab.bsky.social · 11/06/2026

Depletion by RNAi led to spectacular phenotypes with disruption of inter-doublet connections, loss of multiple flagellar components and inhibition of motility

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Philippe Bastin's Lab @bastinlab.bsky.social · 11/06/2026

With iterative-UExM, she revealed the repetitive pattern of CCDC40 associated to the 96nm repeat

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Philippe Bastin's Lab @bastinlab.bsky.social · 11/06/2026

The project was initiated by Thierry Blisnick following discussions with @meilhacsigolene.bsky.social and Amaia Ochendorena Saa who were using the CCDC40 mutant to investigate cilia contribution cilia to left-right asymmetry www.biorxiv.org/content/10.6.... Thierry did scanning EM of the mouse node

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Philippe Bastin's Lab @bastinlab.bsky.social · 11/06/2026

@chrisgirardb.bsky.social Christine’s first manuscript is on BioRXiv! She investigated the CCDC40 protein in trypanosomes with superb expansion images and unexpected findings! www.biorxiv.org/content/10.6...

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Philippe Bastin's Lab @bastinlab.bsky.social · 10/06/2026

Also a big thank you to Mallory Perrin-Wolf and her team for fantastic support, to Laurence Isnard Emma Lepretre for the exhibit with tsetse fly and mosquito models and to Geneviève Milon for having brought back to life Edouard Chatton’s magnificent drawings.

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Philippe Bastin's Lab @bastinlab.bsky.social · 10/06/2026

Great science at our symposium “Grand challenges on vector-borne diseases” @pasteur.fr last week, showing the richness, diversity and creativity of the field, with original strategies to control vector populations and transmission. Many thanks to all speakers for exceptional presentations!

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Philippe Bastin's Lab @bastinlab.bsky.social · 04/06/2026

Getting redy for the symposium tomorrow... @pasteur.fr

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 02/06/2026

📢 Save the date! Join us on July 2, 2026, at IAB (#Grenoble) for: 🔬 Parasite Life Cycles Unveiled: Sex, Regulation and Host Adaptation 4 leading scientists will discuss parasite development and host–parasite interactions. 🥙 Free attendance + Lebanese lunch Register: forms.gle/a5fdoVPqgNq3...

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ParasitesRule @parasitesrule.org · 27/05/2026

Registration and abstract submission are now open for the 2026 Kinetoplastid Molecular Cell Biology Meeting (KMCB). @rmc9z.bsky.social @omarharb.org 🗓 September 8–12, 2026 ⏰Abstract deadline June 22 Submit your abstract and register at parasitesrule.com/kmcb #KMCB #Parasitology #Kinetoplastids

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Philippe Bastin's Lab @bastinlab.bsky.social · 21/05/2026

Lovely time at Antwerp University for the joint meeting of the Belgian Society for Parasitology and Protistology and the Dutch society for Parasitology. Many thanks to Sarah Hendrickx for the invitation!

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Many thanks to the efforts of all lab members and collaborators over 25 years! 👍

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

So, we are finally coming up with this (probably too complicated) model, suggestions welcome! Would KIN2B be the ancestor of all IFT kinesins? Or is it a degenerate version of another kinesin?

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Daniel Abbühl then developed Cas9 marker-free approach with sufficiently high efficiency to monitor impact of gene disruption and with @chrisgirardb.bsky.social revealed that KIN2B was indeed essential for flagellum construction in T. brucei as in L. mexicana

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

So, we thought that KIN2A was the major IFT carrier and yet its knockout gave little phenotype in T. brucei and L. mexicana, KIN2B being able to take over! While looking minor in abundance, KIN2B turned out to be essential for flagellum construction and KO could not be obtained in trypanosomes!

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

We were reinsured to hear that Jack Sunter, Ziyin Wang, Cécile Fort and @zephyris-science.bsky.social made similar observations in Leishmania mexicana

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Aline tried multiple combination of IFT and kinesins but while single tagging worked, double tagging failed multiple times, possibly because of steric hindrance. Fortunately, the combination KIN2B/IFT140 worked out and gave the solution: only a handful of KIN2B shift IFT proteins to the tip

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Thanks to the heroic effort of Aline Alves, we finally revealed that KIN2A and KIN2B show different localisation and different trafficking profiles. But neither of them as sufficient to explain the actual frequency of IFT trafficking while their addition looked too abundant!

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Moara Lemos went to Munich to initiate some in vitro work in the team of Zeynep Ökten, Augustine Cleetus developed this further and revealed the peculiarities of each trypanosome kinesin, which can walk on mammalian microtubules

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Slava Yurchenko and Kika Pašuthová produced a detailed phylogenomic analysis to find out that KIN2A and KIN2B were specific to Euglenozoa (both parasitic and free-living organisms) and that KAP was missing in all of them

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Combined KIN2A and KIN2B knockdown showed that they were involved in IFT and flagellar length control, @ebertiaux.bsky.social picked up by developing the grow-and-lock model doi.org/10.1016/j.cu... Related findings were made by the group of @mattwelchlab.bsky.social doi:10.1242/jcs.129213

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Later on, @sabsalon.bsky.social was the first one to visualise IFT in T. brucei upon overexpression of GFP::IFT52 (with an analogical camera!). www.molbiolcell.org/doi/10.1091/... All IFT proteins could be imaged but neither endogenous tagging nor overexpression gave clear results for KIN2A/KIN2B

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

@lindakohl.bsky.social then post-doc in the lab reassembled the first kinesin gene in 2001 (at that time, the genome was not complete). She knocked it down but no phenotype was visible in contrast to other IFT genes clearly involved in flagellum construction link.springer.com/article/10.1...

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Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 13/05/2026

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport www.biorxiv.org/content/10.64898/20…

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Laura Cantini @cantinilab.bsky.social · 12/05/2026

📢 We are recruiting! We are looking for postdoctoral researchers to join my team at @pasteur.fr (research.pasteur.fr/en/team/mach...). We develop AI methods to infer cellular dynamics and gene regulation. If you are interested, send me an email with your CV. We look forward to hearing from you!

research.pasteur.fr

Machine Learning for integrative genomics – Research

Single-cell high-throughput sequencing, a major breakthrough in life sciences, allows to access the integrated molecular profiles of thousands of cells in a single experiment. This abundance of data p...

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Royal Microscopical Society @royalmicrosoc.bsky.social · 12/05/2026

We are very pleased to announce Prof. Paul Guichard and Dr. Virginie Hamel @centriolelab.bsky.social as joint winners of the RMS Award for Light Microscopy 🔬 👏 🏅 Huge congratulations to both! Read more about Paul and Virginie's achievements: www.rms.org.uk/resource/pro...

Prof. Paul Guichard (left) and Dr. Virginie Hamel both pictured smiling against a plain background. Head and shoulders images.

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CNRS Biologie @cnrsbiologie.bsky.social · 29/04/2026

🔬 Étudier l’organisation tridimensionnelle des génomes Les travaux de @rkoszul.bsky.social, médaille d’argent du @cnrs.fr, apportent des réponses clés sur des processus fondamentaux ! 👋 @pasteur.fr 👉 Lire le portrait : buff.ly/KyFOrjq

buff.ly

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Joachim Frank @joachim123.bsky.social · 29/04/2026

I came here in 1975. I'm a Nobel Prize-winning scientist born in Germany during WWII, came here in 1975 thinking there was no way fascism could take hold in this country. I was wrong. I don't not want to be book-ended by two fascist regimes. We will stand up and set things right.

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Philippe Bastin's Lab @bastinlab.bsky.social · 23/04/2026

A brilliant scientist and such a nice guy 😢

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Susana Godinho @susanagodinho.bsky.social · 22/04/2026

Our flagship conference celebrating everything centrosomes and cilia returns this year and it promises to be another exceptional scientific event in the beautiful city of Lausanne, 1–4 September. 👉 Abstract submission+registration deadline 1 June Don’t miss the opportunity to share your research 🤩

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Mill_lab @cilialab.bsky.social · 20/04/2026

Tuesday is finally our next big session on all things #cilia, #centrosomes & gloriously kick-ass #CellBiology. Free, open to all aficionados, and frankly no excuse not to join. 👀 Unregistered? Easily fixed 👇 www.eventbrite.co.uk/e/bscb-genso...

eventbrite.co.uk

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

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