Reposted by Barrie WilkinsonThe Tennessee Holler @thetnholler.bsky.social · 27/08/2026🇬🇧 ♥️ London honors Dolly 🎵 (H/T @ikebarinholtz.bsky.social ) 251148245
Reposted by Barrie WilkinsonSusan Schlimpert @s-lab.bsky.social · 25/08/2026It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27 03319
Reposted by Barrie WilkinsonMayor of London, Sadiq Khan @london.gov.uk · 20/08/2026The toxic air our children were breathing was stunting their lungs. For too many young Londoners, that was the reality before the ULEZ. New independent findings show their lung health has improved significantly in Central London. That’s the difference cleaner air can make.theguardian.comIntroducing Ulez was my hardest decision as mayor of London – but now we know its astonishing impact | Sadiq KhanCritics said I was attacking motorists. It’s more important for me that the city’s children are no longer breathing dangerous levels of pollution, says London mayor Sadiq Khan 16889228
Reposted by Barrie WilkinsonKevin M. Kruse @kevinmkruse.bsky.social · 08/07/2026I don't know, man, I think if Joe Biden had kept confusing Zelenskyy with Putin and Iran with Japan, the media might have made a pretty big deal about it? 18383671638
Reposted by Barrie WilkinsonAinsley Beaton @ainsley-beaton.bsky.social · 28/05/2026Another paper out in the @microbiologysociety.org special issue on Advances in the biology of Actinomycetes! Congratulations to everyone involved @matthutchings.bsky.social @barriewilks.bsky.social @johninnescentre.bsky.social www.microbiologyresearch.org/content/jour...microbiologyresearch.orgDefining the OrrA regulon and its role in development and antibiotic production in Streptomyces venezuelae NRRL B-65442Streptomyces bacteria have complex life cycles involving hyphal growth, sporulation and the production of diverse specialised metabolites, including antibiotics. In this study, we investigated the rol... 074
Reposted by Barrie WilkinsonThom Booth @thombooth.bsky.social · 11/05/2026Our study into the incredible genome of Embleya australiensis has been published in Microbial Genomics. We've shown that Embleya carry gigantic secondary chromosomes around 4 - 6 Mb in size! Enjoy reading and don't hesitate to reach out! www.microbiologyresearch.org/content/jour... 🧪💻🦠 1/4 1167
Reposted by Barrie WilkinsonSusan Schlimpert @s-lab.bsky.social · 07/05/2026Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...jic.ac.ukEarly Career Microbiologists Mini-Symposium 2026 | John Innes CentreThe Department of Molecular Microbiology is organising a one and a half day Early- Career Microbiologists Mini-Symposium. The symposium will be held from Tuesday 22nd – Wednesday 23rd September 2026. 03746
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 28/03/2026The Microbe Zoo will be going to the Royal Society summer science exhibition 2026!!! Fantastic achievement by @sawtrust.bsky.social and @norwichmicro.bsky.social royalsociety.org/science-even... 23512
Reposted by Barrie WilkinsonActinoBase @actinobase.bsky.social · 16/02/2026If anyone is interested in working on these bacteria @johninnescentre.bsky.social has protocols, strains, plasmids and a genome database available here: streptomyces.org.ukstreptomyces.org.ukStreptomyces.org.uk 01213
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 16/02/2026Research into filamentous actinomycetes, the antibiotic producers, is in steep decline. Loads of natural products chemistry research worldwide but not much aimed at understanding their biology and ecology. The latter is key to unlocking their specialised metabolism link.springer.com/article/10.1...link.springer.comRevitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis - Natural Products and BioprospectingAbstract The crisis of antimicrobial resistance (AMR) is escalating while the antibiotic pipeline remains stagnant. Our bibliometric analysis of eight decades of literature reveals a critical imbalanc... 23622
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 16/01/2026Good to see this out - new CRISPRi work from the @ryanfseipke.bsky.social lab/ #microsky #streptomyces A platform for CRISPRi-seq in Streptomyces albidoflavus journals.asm.org/doi/pdf/10.1...journals.asm.org 0126
Reposted by Barrie WilkinsonTom McLean @tommclean.bsky.social · 16/12/2025Delighted to see the main work from my PhD finally published in @mbio.bsky.social! It all started with the observation that deleting the cutRS two-component system in S. venezuelae caused this amazing explorer phenotype in the presence of glucose. But what was going on?! (1/n) 14218
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 15/12/2025Very happy to see this remarkable work published. Led by @tommclean.bsky.social and @ainsley-beaton.bsky.social. We show how Streptomyces bacteria sense & respond to misfolded secreted proteins. A great collaboration with @barriewilks.bsky.social #microsky 1/2 journals.asm.org/doi/epub/10....journals.asm.orgThe conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces 12518
Reposted by Barrie WilkinsonLeah McPhillips @leahmcphillips.bsky.social · 11/12/2025📄 Delighted to share that the preprint of my main PhD work is out now! 👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏 🧵 below! www.biorxiv.org/content/10.6...biorxiv.orgStable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systemsLow-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across generations. These partition systems actively segregate siste... 23619
Reposted by Barrie WilkinsonQuadram Institute @quadraminstitute.bsky.social · 03/11/2025If successful, the ViTaL-D Study would be a step towards using biofortified tomatoes to overcome a growing global problem of vitamin D deficiency 🌎 This step forward is of particular interest to people who follow a plant-based diet because vegan sources of vitamin D are nearly non-existent 🌿buff.lyNeed a winter warmer? Groundbreaking gene-edited tomato soup trial with higher levels of 'Sunshine' vitamin recruiting now - Quadram InstituteHuman trial of gene edited food, to understand whether biofortifying tomatoes in this way leads to higher levels of vitamin D in the blood 094
Reposted by Barrie Wilkinsonpfeilmeier.bsky.social @pfeilmeier.bsky.social · 31/10/2025We are hiring‼️ Two cool projects in my group for a PhD student in plant immunity and for a Postdoc in plant microbiota research 🌿🧫🚀🚀 1108
Reposted by Barrie WilkinsonSusan Schlimpert @s-lab.bsky.social · 13/10/2025We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs. Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...biodtp.norwichresearchpark.ac.ukBeyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training PartnershipJoin us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats. 03140
Reposted by Barrie WilkinsonTung Le @tunglejic.bsky.social · 03/10/2025Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!! 04987
Reposted by Barrie WilkinsonMichael Webster @michaelwebster.bsky.social · 03/10/2025Start independent research at the JIC with us 👇. Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes. Please do get in touch by email if you'd like to know more 👍 01718
Reposted by Barrie WilkinsonSusan Schlimpert @s-lab.bsky.social · 21/08/2025There is still some time left to apply for these two Group Leader positions in Plant Biology and Microbe-Plant Interactions. Spread the word, apply & become our colleague @johninnescentre.bsky.social 01116
Reposted by Barrie WilkinsonMelissah Rowe @melissahrowe.bsky.social · 16/08/2025Interested in host-associated microbiomes? Attending @eseb2025.bsky.social? Then come check out Symposium S07 on Monday August 18th and hear all about how microbiomes contribute to adaptation. Gut microbiomes, climate change, thermal physiology, behaviour, invasion biology, blood-feeding, and more! 13118
Reposted by Barrie WilkinsonJohn Innes Centre @johninnescentre.bsky.social · 09/08/2025VACANCY - We’re recruiting for a visionary group leader to lead fundamental research on Discovery Plant Science as part of our vibrant research community Successful candidate will be offered a six-year tenure-track position with the opportunity to apply for tenure: www.jic.ac.uk/vacancies/gr... 03343
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 07/08/2025Ever wondered why some antibiotics are made by Streptomyces on agar plates but not in liquid cultures? Read this work on redox control of antibiotic biosynthesis. Led by katienoble241.bsky.social and Rebecca Devine, and in collaboration with @barriewilks.bsky.social journals.asm.org/doi/10.1128/...journals.asm.org 67335
Reposted by Barrie WilkinsonChristine Faulkner @pdchristine.bsky.social · 18/07/2025Exciting times to be at @johninnescentre.bsky.social ! www.jic.ac.uk/press-releas...jic.ac.ukMajor funding boost to bring world leading researchers to the John Innes Centre | John Innes CentreThe John Innes Centre has been awarded an equal share of the new £54 million Global Talent Fund, to attract and support leading researchers and their teams to relocate to the UK. The new Global Talent... 05327
Reposted by Barrie WilkinsonJohn Innes Centre @johninnescentre.bsky.social · 17/07/2025We’re pleased to announce two new vacancies for senior roles at our institute: Group Leader in Discovery Plant Sciences: www.jic.ac.uk/vacancies/gr... 🗓️ Closes 25 August Independent Fellowship in Plant-Associated Microbial Interactions: www.jic.ac.uk/vacancies/in... 🗓️ Closes 5 September 35174
Barrie Wilkinson @barriewilks.bsky.social · 26/06/2025Delighted to be speaking on "A platform for lantibiotic diversification" at SynBioAustralasia 2025 this November in Wellington. If you’re working at the intersection of biology and engineering — don’t miss it. 🔗 synbioaustralasia.org/upcoming-conference #SBA2025 #SyntheticBiology #SynBioCommunitysynbioaustralasia.orgSBA 2025 conferenceSBA 2025 conference Synthetic Biology Australasia New Zealand synbio conference 041
Reposted by Barrie WilkinsonAndy Truman @andytruman4.bsky.social · 20/05/2025Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀 www.pnas.org/doi/10.1073/... The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic. @johninnescentre.bsky.socialpnas.orgIdentification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target | PNASThe natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confe... 12612
Reposted by Barrie WilkinsonJohn Innes Centre @johninnescentre.bsky.social · 09/05/2025EVENT - Early Career Microbiologists Mini-Symposium Join our Department of Molecular #Microbiology Early Career Microbiologists Mini-Symposium. Application deadline: 9 June 2025. Event: 15 - 16 September 2025. The John Innes Centre, NR4 7UH Find out more and apply: www.jic.ac.uk/event/early-...jic.ac.ukEarly Career Microbiologists Mini-Symposium 2025 | John Innes CentreThe Department of Molecular Microbiology is organising a one and a half day Early Career Microbiologists Mini-Symposium. The symposium will be held from Monday 15 – Tuesday 16 September 2025. 01212
Reposted by Barrie WilkinsonSuperbugs 🦠🔬🏫🧒🏽 @superbugs.bsky.social · 29/04/2025Happy International Day of Immunology! 🧬🔬💉 “Measles: A Dangerous Illness” — a letter by Roald Dahl 'It is not yet generally accepted that measles can be a dangerous illness. Believe me, it is.'superbugs.online“Measles: A Dangerous Illness” — a letter by Roald Dahl — Superbugs - The microbial world in, on and around usOriginally published in a pamphlet for the Sandwell Health Authority in the West Midlands in 1986 0108
Reposted by Barrie WilkinsonBrian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · 24/04/2025Identification of a specific, pre-existing beta-lactam antibiotic for treating Lyme disease Borrelia infections. Cool new report from @jutraslab.bsky.social Brandon Jutras & colleagues. pubmed.ncbi.nlm.nih.gov/40267215/ #MicroSky 🦠🧫🔬 1176
Reposted by Barrie WilkinsonNature @nature.com · 23/04/2025Researchers pinpoint the genes responsible for the final three pea traits studied by Gregor Mendel more than 160 years ago go.nature.com/3EC3eqTgo.nature.comCentury-old genetics mystery of Mendel’s peas finally solvedResearchers pinpoint the genes responsible for the final three pea traits studied by the famed citizen scientist. 113951
Reposted by Barrie WilkinsonAntony Dodd @antdodd.bsky.social · 10/04/2025PhD opportunity in my lab @johninnescentre.bsky.social, on circadian interactions between plants and bacteria. Fully funded. Part of @microclockerc.bsky.social in collaboration with @evolvedbiofilm.bsky.social @marthamerrow.bsky.social #chronobiology #ERCSyG www.findaphd.com/phds/project...findaphd.comHow plants and microbes synchronize their daily rhythms to keep fit at John Innes Centre on FindAPhD.comPhD Project - How plants and microbes synchronize their daily rhythms to keep fit at John Innes Centre, listed on FindAPhD.com 01823
Reposted by Barrie WilkinsonGerry Wright @gdwantibiotics.bsky.social · 26/03/2025The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdhardcu.beA broad-spectrum lasso peptide antibiotic targeting the bacterial ribosomeNature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common... 37544
Reposted by Barrie WilkinsonMicah @rincewind.run · 24/03/2025congestion pricing is one of the most comprehensively successful policies NYC has ever seen, so of course all the worst people want to get rid of it 202895517
Reposted by Barrie WilkinsonSam Williams @samwill.bsky.social · 10/12/2024MiBIG 4.0 is online! #secmet #BGC #mibig #microsky academic.oup.com/nar/advance-...academic.oup.comMIBiG 4.0: advancing biosynthetic gene cluster curation through global collaborationAbstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag 02511
Reposted by Barrie WilkinsonCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/12/2024Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...nature.comDiscovery and engineering of the antibody response to a prominent skin commensal - NatureNature - Discovery and engineering of the antibody response to a prominent skin commensal 624272
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 21/03/2025Of interest to biotech - if we delete the cutRS operon in Streptomyces coelicolor or S. venezuelae we get massive over production of antibiotics in the presence of glucose. It bypasses carbon catabolise repression (we don’t know how…yet). #microsky 082
Reposted by Barrie WilkinsonTom McLean @tommclean.bsky.social · 21/03/2025Almost 8 years after starting this project finally happy to share the main research from my PhD! Couldn't have done it without the amazing help from @ainsley-beaton.bsky.social! We untangled a fascinating new redox sensor with the most extraordinary growth phenotype (I'm biased) in Streptomyces! 14417
Reposted by Barrie WilkinsonAinsley Beaton @ainsley-beaton.bsky.social · 21/03/2025Further insight into how CutRS functions in Streptomyces and some thoughts on how its redox state detection via conserved dual cysteine residues in the extra cellular domain of a sensor kinase may be present in almost all bacteria @tommclean.bsky.social @matthutchings.bsky.social 0178
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 21/03/2025Very happy to share this work led by @tommclean.bsky.social and @ainsley-beaton.bsky.social. The conserved Streptomyces sensor kinase CutS senses disulphide bond formation outside the cell. If it fails CutS activates CutR which switches on production of foldase HtrA3 www.biorxiv.org/content/10.1...biorxiv.orgExtracellular redox sensors control the protein secretion stress response in StreptomycesTranslocating unfolded polypeptides across membranes is essential in all domains of life and in bacteria requires the conserved Sec machinery and ATP. Bacterial Sec substrates fold outside the cell an... 22714
Reposted by Barrie WilkinsonGeorge Conway ⚖️🇺🇸 @gtconway.bsky.social · 19/03/2025“Musk is killing Tesla. His lack of integrity, lack of internal consistency, and deeply fascistic leanings are now on full display for the world to see. And the world has responded by violently throwing up in their mouths.”planetearthandbeyond.coTesla Is Dying, And Polestar Wants To Kill ItThe industry is exorcising Musk. 43595251858
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 13/03/2025Today we updated streptomyces.org.uk/strepstrains... with lists of useful Streptomyces strains and plasmids we have @johninnescentre.bsky.social and details of how to request them.streptomyces.org.ukStrepStrains 02311
Reposted by Barrie WilkinsonCentre for Microbial Interactions @norwichmicro.bsky.social · 11/03/2025Great opportunity for early career researchers at Norwich Research Park to present their work on microbial genomics 🧬 Abstract deadline is 3rd April @quadraminstitute.bsky.social @johninnescentre.bsky.social @earlhaminst.bsky.social @uniofeastanglia.bsky.social @thesainsburylab.bsky.social 044
Reposted by Barrie WilkinsonMatt Hutchings @handle.invalid · 10/03/2025Redox control of antibiotic biosynthesis in Streptomyces. Remarkable work led by @katienoble241.bsky.social and Rebecca Devine demonstrates why antibiotic biosynthesis is often switched on in solid cultures and off in liquid. www.biorxiv.org/content/10.1...biorxiv.orgRedox control of antibiotic biosynthesisStreptomyces bacteria make diverse specialised metabolites that form the basis of ~55% of clinically used antibiotics. Despite this, only 3% of their encoded specialised metabolites have been matched ... 13324
Reposted by Barrie WilkinsonCentre for Microbial Interactions @norwichmicro.bsky.social · 03/03/2025We’ve had a busy few weeks with events and engagement. Thanks to everyone who supported us at Norwich Science Festival and at our inaugural annual conference! It was great to see the microbiology community come together and to share our work with new audiences 🦠 0125
Reposted by Barrie WilkinsonQuadram Institute @quadraminstitute.bsky.social · 25/02/2025The @norwichmicro.bsky.social (CMI) Annual Conference starts tomorrow 🦠 📽️ Get a sneak peak of some of the scientific posters that will be on display with videos on microbiology research from across Norwich Research Park ⤵️buff.lyCentre for Microbial Interactions Annual Conference 2025 poster preview - Quadram InstituteThe Centre for Microbial Interactions (CMI) is an initiative that has been launched to support and promote the ground-breaking discovery research conducted by the extensive microbiology community at… 056