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Barrie Wilkinson

@barriewilks.bsky.social
716 followers 580 following 16 posts

Natural products/specialised metabolism @JohnInnesCentre.bsky.social www.jic.ac.uk/people/barrie-wilkins… www.cmi-norwich.ac.uk/people/prof-b…

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Reposted by Barrie Wilkinson
The Tennessee Holler @thetnholler.bsky.social · 27/08/2026
🇬🇧 ♥️ London honors Dolly 🎵 (H/T @ikebarinholtz.bsky.social )
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Susan Schlimpert @s-lab.bsky.social · 25/08/2026
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27
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Mayor of London, Sadiq Khan @london.gov.uk · 20/08/2026
The toxic air our children were breathing was stunting their lungs. For too many young Londoners, that was the reality before the ULEZ. New independent findings show their lung health has improved significantly in Central London. That’s the difference cleaner air can make.
theguardian.com
Introducing Ulez was my hardest decision as mayor of London – but now we know its astonishing impact | Sadiq Khan
Critics said I was attacking motorists. It’s more important for me that the city’s children are no longer breathing dangerous levels of pollution, says London mayor Sadiq Khan
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Kevin M. Kruse @kevinmkruse.bsky.social · 08/07/2026
I don't know, man, I think if Joe Biden had kept confusing Zelenskyy with Putin and Iran with Japan, the media might have made a pretty big deal about it?
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Ainsley Beaton @ainsley-beaton.bsky.social · 28/05/2026
Another paper out in the @microbiologysociety.org special issue on Advances in the biology of Actinomycetes! Congratulations to everyone involved @matthutchings.bsky.social @barriewilks.bsky.social @johninnescentre.bsky.social www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Defining the OrrA regulon and its role in development and antibiotic production in Streptomyces venezuelae NRRL B-65442
Streptomyces bacteria have complex life cycles involving hyphal growth, sporulation and the production of diverse specialised metabolites, including antibiotics. In this study, we investigated the rol...
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Reposted by Barrie Wilkinson
Thom Booth @thombooth.bsky.social · 11/05/2026
Our study into the incredible genome of Embleya australiensis has been published in Microbial Genomics. We've shown that Embleya carry gigantic secondary chromosomes around 4 - 6 Mb in size! Enjoy reading and don't hesitate to reach out! www.microbiologyresearch.org/content/jour... 🧪💻🦠 1/4
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Susan Schlimpert @s-lab.bsky.social · 07/05/2026
Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...
jic.ac.uk
Early Career Microbiologists Mini-Symposium 2026 | John Innes Centre
The Department of Molecular Microbiology is organising a one and a half day Early- Career Microbiologists Mini-Symposium. The symposium will be held from Tuesday 22nd – Wednesday 23rd September 2026.
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Reposted by Barrie Wilkinson
Matt Hutchings @handle.invalid · 28/03/2026
The Microbe Zoo will be going to the Royal Society summer science exhibition 2026!!! Fantastic achievement by @sawtrust.bsky.social and @norwichmicro.bsky.social royalsociety.org/science-even...
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ActinoBase @actinobase.bsky.social · 16/02/2026
If anyone is interested in working on these bacteria @johninnescentre.bsky.social has protocols, strains, plasmids and a genome database available here: streptomyces.org.uk
streptomyces.org.uk
Streptomyces.org.uk
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Matt Hutchings @handle.invalid · 16/02/2026
Research into filamentous actinomycetes, the antibiotic producers, is in steep decline. Loads of natural products chemistry research worldwide but not much aimed at understanding their biology and ecology. The latter is key to unlocking their specialised metabolism link.springer.com/article/10.1...
link.springer.com
Revitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis - Natural Products and Bioprospecting
Abstract The crisis of antimicrobial resistance (AMR) is escalating while the antibiotic pipeline remains stagnant. Our bibliometric analysis of eight decades of literature reveals a critical imbalanc...
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Matt Hutchings @handle.invalid · 16/01/2026
Good to see this out - new CRISPRi work from the @ryanfseipke.bsky.social lab/ #microsky #streptomyces A platform for CRISPRi-seq in Streptomyces albidoflavus journals.asm.org/doi/pdf/10.1...
journals.asm.org
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Tom McLean @tommclean.bsky.social · 16/12/2025
Delighted to see the main work from my PhD finally published in @mbio.bsky.social! It all started with the observation that deleting the cutRS two-component system in S. venezuelae caused this amazing explorer phenotype in the presence of glucose. But what was going on?! (1/n)
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Matt Hutchings @handle.invalid · 15/12/2025
Very happy to see this remarkable work published. Led by @tommclean.bsky.social and @ainsley-beaton.bsky.social. We show how Streptomyces bacteria sense & respond to misfolded secreted proteins. A great collaboration with @barriewilks.bsky.social #microsky 1/2 journals.asm.org/doi/epub/10....
journals.asm.org
The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces
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Leah McPhillips @leahmcphillips.bsky.social · 11/12/2025
📄 Delighted to share that the preprint of my main PhD work is out now! 👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏 🧵 below! www.biorxiv.org/content/10.6...
biorxiv.org
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems
Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across generations. These partition systems actively segregate siste...
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Reposted by Barrie Wilkinson
Quadram Institute @quadraminstitute.bsky.social · 03/11/2025
If successful, the ViTaL-D Study would be a step towards using biofortified tomatoes to overcome a growing global problem of vitamin D deficiency 🌎 This step forward is of particular interest to people who follow a plant-based diet because vegan sources of vitamin D are nearly non-existent 🌿
buff.ly
Need a winter warmer? Groundbreaking gene-edited tomato soup trial with higher levels of 'Sunshine' vitamin recruiting now - Quadram Institute
Human trial of gene edited food, to understand whether biofortifying tomatoes in this way leads to higher levels of vitamin D in the blood
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Reposted by Barrie Wilkinson
pfeilmeier.bsky.social @pfeilmeier.bsky.social · 31/10/2025
We are hiring‼️ Two cool projects in my group for a PhD student in plant immunity and for a Postdoc in plant microbiota research 🌿🧫🚀🚀
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Susan Schlimpert @s-lab.bsky.social · 13/10/2025
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs. Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
biodtp.norwichresearchpark.ac.uk
Beyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training Partnership
Join us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats.
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Reposted by Barrie Wilkinson
Tung Le @tunglejic.bsky.social · 03/10/2025
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
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Michael Webster @michaelwebster.bsky.social · 03/10/2025
Start independent research at the JIC with us 👇. Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes. Please do get in touch by email if you'd like to know more 👍
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Barrie Wilkinson @barriewilks.bsky.social · 04/09/2025
🤣
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Reposted by Barrie Wilkinson
Susan Schlimpert @s-lab.bsky.social · 21/08/2025
There is still some time left to apply for these two Group Leader positions in Plant Biology and Microbe-Plant Interactions. Spread the word, apply & become our colleague @johninnescentre.bsky.social
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Reposted by Barrie Wilkinson
Melissah Rowe @melissahrowe.bsky.social · 16/08/2025
Interested in host-associated microbiomes? Attending @eseb2025.bsky.social? Then come check out Symposium S07 on Monday August 18th and hear all about how microbiomes contribute to adaptation. Gut microbiomes, climate change, thermal physiology, behaviour, invasion biology, blood-feeding, and more!
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Barrie Wilkinson @barriewilks.bsky.social · 12/08/2025
🤣
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John Innes Centre @johninnescentre.bsky.social · 09/08/2025
VACANCY - We’re recruiting for a visionary group leader to lead fundamental research on Discovery Plant Science as part of our vibrant research community Successful candidate will be offered a six-year tenure-track position with the opportunity to apply for tenure: www.jic.ac.uk/vacancies/gr...
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Matt Hutchings @handle.invalid · 07/08/2025
Ever wondered why some antibiotics are made by Streptomyces on agar plates but not in liquid cultures? Read this work on redox control of antibiotic biosynthesis. Led by katienoble241.bsky.social and Rebecca Devine, and in collaboration with @barriewilks.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
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Barrie Wilkinson @barriewilks.bsky.social · 19/07/2025
Here we go 🇬🇧🦁🇮🇪🏉
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Reposted by Barrie Wilkinson
Christine Faulkner @pdchristine.bsky.social · 18/07/2025
Exciting times to be at @johninnescentre.bsky.social ! www.jic.ac.uk/press-releas...
jic.ac.uk
Major funding boost to bring world leading researchers to the John Innes Centre | John Innes Centre
The John Innes Centre has been awarded an equal share of the new £54 million Global Talent Fund, to attract and support leading researchers and their teams to relocate to the UK. The new Global Talent...
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Reposted by Barrie Wilkinson
John Innes Centre @johninnescentre.bsky.social · 17/07/2025
We’re pleased to announce two new vacancies for senior roles at our institute: Group Leader in Discovery Plant Sciences: www.jic.ac.uk/vacancies/gr... 🗓️ Closes 25 August Independent Fellowship in Plant-Associated Microbial Interactions: www.jic.ac.uk/vacancies/in... 🗓️ Closes 5 September
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Barrie Wilkinson @barriewilks.bsky.social · 16/07/2025
Congrats, great to see this out in full!
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Barrie Wilkinson @barriewilks.bsky.social · 26/06/2025
Delighted to be speaking on "A platform for lantibiotic diversification" at SynBioAustralasia 2025 this November in Wellington. If you’re working at the intersection of biology and engineering — don’t miss it. 🔗 synbioaustralasia.org/upcoming-conference #SBA2025 #SyntheticBiology #SynBioCommunity
synbioaustralasia.org
SBA 2025 conference
SBA 2025 conference Synthetic Biology Australasia New Zealand synbio conference
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Reposted by Barrie Wilkinson
Andy Truman @andytruman4.bsky.social · 20/05/2025
Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀 www.pnas.org/doi/10.1073/... The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic. @johninnescentre.bsky.social
pnas.org
Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target | PNAS
The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confe...
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Reposted by Barrie Wilkinson
John Innes Centre @johninnescentre.bsky.social · 09/05/2025
EVENT - Early Career Microbiologists Mini-Symposium Join our Department of Molecular #Microbiology Early Career Microbiologists Mini-Symposium. Application deadline: 9 June 2025. Event: 15 - 16 September 2025. The John Innes Centre, NR4 7UH Find out more and apply: www.jic.ac.uk/event/early-...
jic.ac.uk
Early Career Microbiologists Mini-Symposium 2025 | John Innes Centre
The Department of Molecular Microbiology is organising a one and a half day Early Career Microbiologists Mini-Symposium. The symposium will be held from Monday 15 – Tuesday 16 September 2025.
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Reposted by Barrie Wilkinson
Superbugs 🦠🔬🏫🧒🏽 @superbugs.bsky.social · 29/04/2025
Happy International Day of Immunology! 🧬🔬💉 “Measles: A Dangerous Illness” — a letter by Roald Dahl 'It is not yet generally accepted that measles can be a dangerous illness. Believe me, it is.'
superbugs.online
“Measles: A Dangerous Illness” — a letter by Roald Dahl — Superbugs - The microbial world in, on and around us
Originally published in a pamphlet for the Sandwell Health Authority in the West Midlands in 1986
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Reposted by Barrie Wilkinson
Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · 24/04/2025
Identification of a specific, pre-existing beta-lactam antibiotic for treating Lyme disease Borrelia infections. Cool new report from @jutraslab.bsky.social Brandon Jutras & colleagues. pubmed.ncbi.nlm.nih.gov/40267215/ #MicroSky 🦠🧫🔬
Cover of new issue of Science Translational Medicine, showing an Ixodes scapularis tick
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Nature @nature.com · 23/04/2025
Researchers pinpoint the genes responsible for the final three pea traits studied by Gregor Mendel more than 160 years ago go.nature.com/3EC3eqT
go.nature.com
Century-old genetics mystery of Mendel’s peas finally solved
Researchers pinpoint the genes responsible for the final three pea traits studied by the famed citizen scientist.
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Antony Dodd @antdodd.bsky.social · 10/04/2025
PhD opportunity in my lab @johninnescentre.bsky.social, on circadian interactions between plants and bacteria. Fully funded. Part of @microclockerc.bsky.social in collaboration with @evolvedbiofilm.bsky.social @marthamerrow.bsky.social #chronobiology #ERCSyG www.findaphd.com/phds/project...
findaphd.com
How plants and microbes synchronize their daily rhythms to keep fit at John Innes Centre on FindAPhD.com
PhD Project - How plants and microbes synchronize their daily rhythms to keep fit at John Innes Centre, listed on FindAPhD.com
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Gerry Wright @gdwantibiotics.bsky.social · 26/03/2025
The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha
rdcu.be
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
Nature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...
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Micah @rincewind.run · 24/03/2025
congestion pricing is one of the most comprehensively successful policies NYC has ever seen, so of course all the worst people want to get rid of it
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Sam Williams @samwill.bsky.social · 10/12/2024
MiBIG 4.0 is online! #secmet #BGC #mibig #microsky academic.oup.com/nar/advance-...
academic.oup.com
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag
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Reposted by Barrie Wilkinson
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/12/2024
Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...
nature.com
Discovery and engineering of the antibody response to a prominent skin commensal - Nature
Nature - Discovery and engineering of the antibody response to a prominent skin commensal
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Matt Hutchings @handle.invalid · 21/03/2025
Of interest to biotech - if we delete the cutRS operon in Streptomyces coelicolor or S. venezuelae we get massive over production of antibiotics in the presence of glucose. It bypasses carbon catabolise repression (we don’t know how…yet). #microsky
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Tom McLean @tommclean.bsky.social · 21/03/2025
Almost 8 years after starting this project finally happy to share the main research from my PhD! Couldn't have done it without the amazing help from @ainsley-beaton.bsky.social! We untangled a fascinating new redox sensor with the most extraordinary growth phenotype (I'm biased) in Streptomyces!
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Ainsley Beaton @ainsley-beaton.bsky.social · 21/03/2025
Further insight into how CutRS functions in Streptomyces and some thoughts on how its redox state detection via conserved dual cysteine residues in the extra cellular domain of a sensor kinase may be present in almost all bacteria @tommclean.bsky.social @matthutchings.bsky.social
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Matt Hutchings @handle.invalid · 21/03/2025
Very happy to share this work led by @tommclean.bsky.social and @ainsley-beaton.bsky.social. The conserved Streptomyces sensor kinase CutS senses disulphide bond formation outside the cell. If it fails CutS activates CutR which switches on production of foldase HtrA3 www.biorxiv.org/content/10.1...
biorxiv.org
Extracellular redox sensors control the protein secretion stress response in Streptomyces
Translocating unfolded polypeptides across membranes is essential in all domains of life and in bacteria requires the conserved Sec machinery and ATP. Bacterial Sec substrates fold outside the cell an...
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George Conway ⚖️🇺🇸 @gtconway.bsky.social · 19/03/2025
“Musk is killing Tesla. His lack of integrity, lack of internal consistency, and deeply fascistic leanings are now on full display for the world to see. And the world has responded by violently throwing up in their mouths.”
planetearthandbeyond.co
Tesla Is Dying, And Polestar Wants To Kill It
The industry is exorcising Musk.
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Matt Hutchings @handle.invalid · 13/03/2025
Today we updated streptomyces.org.uk/strepstrains... with lists of useful Streptomyces strains and plasmids we have @johninnescentre.bsky.social and details of how to request them.
streptomyces.org.uk
StrepStrains
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Centre for Microbial Interactions @norwichmicro.bsky.social · 11/03/2025
Great opportunity for early career researchers at Norwich Research Park to present their work on microbial genomics 🧬 Abstract deadline is 3rd April @quadraminstitute.bsky.social @johninnescentre.bsky.social @earlhaminst.bsky.social @uniofeastanglia.bsky.social @thesainsburylab.bsky.social
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Matt Hutchings @handle.invalid · 10/03/2025
Redox control of antibiotic biosynthesis in Streptomyces. Remarkable work led by @katienoble241.bsky.social and Rebecca Devine demonstrates why antibiotic biosynthesis is often switched on in solid cultures and off in liquid. www.biorxiv.org/content/10.1...
biorxiv.org
Redox control of antibiotic biosynthesis
Streptomyces bacteria make diverse specialised metabolites that form the basis of ~55% of clinically used antibiotics. Despite this, only 3% of their encoded specialised metabolites have been matched ...
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Centre for Microbial Interactions @norwichmicro.bsky.social · 03/03/2025
We’ve had a busy few weeks with events and engagement. Thanks to everyone who supported us at Norwich Science Festival and at our inaugural annual conference! It was great to see the microbiology community come together and to share our work with new audiences 🦠
A group of six volunteers at Norwich Science Festival. They are wearing bright orange t-shirts and standing behind two tables displaying microbiology outreach activities for the publicMark Webber standing behind a podium on a conference centre stage. The large screen behind him says ‘Welcome to our Annual Conference 2025’.
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Quadram Institute @quadraminstitute.bsky.social · 25/02/2025
The @norwichmicro.bsky.social (CMI) Annual Conference starts tomorrow 🦠 📽️ Get a sneak peak of some of the scientific posters that will be on display with videos on microbiology research from across Norwich Research Park ⤵️
buff.ly
Centre for Microbial Interactions Annual Conference 2025 poster preview - Quadram Institute
The Centre for Microbial Interactions (CMI) is an initiative that has been launched to support and promote the ground-breaking discovery research conducted by the extensive microbiology community at…
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