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Aydan Szeto

@aydanszeto.bsky.social
2.2K followers 512 following 36 posts

Immunologist @MRC-LMB | Views are my own | he/him 🏳️‍🌈 | I work towards manipulating the Yin and Yang of inflammation #immunology #immunosky

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Aydan Szeto @aydanszeto.bsky.social · 01/06/2025
👀👀 @ilc6.bsky.social #excited
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Sarah Ross @sarahhross.bsky.social · 14/01/2025
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize! Grand Prize: $25K & your essay published in Science Magazine Deadline: Feb 14th Enter: buff.ly/4gS29ZH
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Aydan Szeto @aydanszeto.bsky.social · 08/01/2025
My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.
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Michael Fischbach @mfgrp.bsky.social · 11/12/2024
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
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Sarah Ross @sarahhross.bsky.social · 09/12/2024
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells. buff.ly/3BdtFkS Work from @aydanszeto.bsky.social et al. #Immunology #ILC2s @science.org
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Aydan Szeto @aydanszeto.bsky.social · 01/12/2024
#immunosky Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)! www.nature.com/articles/d41...
nature.com
Notching up a win: fresh tools for activating Notch
Synthetic protein agonists could boost T-cell biomanufacturing and therapeutic strategies.
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Aydan Szeto @aydanszeto.bsky.social · 01/12/2024
RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?
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Hepworth Lab @hepworth-lab.bsky.social · 28/11/2024
New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists! www.findaphd.com/phds/project...
findaphd.com
(Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester on FindAPhD.com
PhD Project - (Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester, listed on FindAPhD.com
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Aydan Szeto @aydanszeto.bsky.social · 27/11/2024
A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity. www.nature.com/articles/s41...
nature.com
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
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Dorothy Bishop @deevybee.bsky.social · 25/11/2024
New blogpost: deevybee.blogspot.com/2024/11/why-...
deevybee.blogspot.com
Why I have resigned from the Royal Society
The Royal Society is a venerable institution founded in 1660, whose original members included such eminent men as Christopher Wren, Robert H...
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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 24/11/2024
🚨🚨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester! Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social #Immunosky #LGBTQSTEM 🏳️‍🌈🏳️‍⚧️🧪 #Academicsky www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Assistant in Tissue Immunology:Oxford Road
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Rod Rahimi @rodrahimi.bsky.social · 19/11/2024
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network Below are the links If you're an immunologist and I have missed you so far, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS
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Aydan Szeto @aydanszeto.bsky.social · 23/11/2024
#immunosky The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
t.co
https://www.nature.com/articles/s41586-024-08216-z
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Tara Sutherland @drtesutherland.bsky.social · 13/11/2024
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
Hyaluronan and collagen III expression in allergic lungNew Slains castle at Cruden Bay
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Aydan Szeto @aydanszeto.bsky.social · 18/11/2024
#immunosky B cell and TFH researchers: Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?
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Anna Molofsky Lab @annamolofskylab.bsky.social · 17/11/2024
ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...
science.org
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...
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Anna Molofsky Lab @annamolofskylab.bsky.social · 17/11/2024
go.bsky.app/Eaua5Jk my starter for neuroimmunology
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Sarah Crome @sarahcrome.bsky.social · 17/11/2024
A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join. go.bsky.app/AjNpW2h
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Rod Rahimi @rodrahimi.bsky.social · 15/11/2024
Wonderful to see the #immunology community growing here. The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added go.bsky.app/PY5tCas go.bsky.app/FmERUoD
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Aydan Szeto @aydanszeto.bsky.social · 15/11/2024
#immunosky Obsessed with our robotic arm loading plates to our Sony ID7000 spectral analyser to dramatically increase our flow throughput. This cytometer literally never blocks so we have complete trust in the whole system to run samples overnight whilst we sleep 😴
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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 12/11/2024
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism? Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Assistant in Tissue Immunology:Oxford Road
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Danielle Beckman @daniellebeckman.bsky.social · 11/11/2024
#MicroscopyMonday is very much alive here and I'm loving it! My take for this week is Neuroinflammation! Under a microscope literally looks like the brain is on fire! 🔥🔬 Instead of gently touching the neurons, microglia changes shape, gets activated and start attacking them. How do we control this?
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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 11/11/2024
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism? The advert to join me & @juanquintana.bsky.social as a research assistant is now live! Drop one of us an email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Assistant in Tissue Immunology:Oxford Road
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Rod Rahimi @rodrahimi.bsky.social · 01/11/2024
This is cool work from Ari and Anna Molofsky's labs "Our study identifies a role for ILC2s in promoting inhibitory synapse formation, thus establishing these cells as important regulators of brain development." #ImmunoSky 🧪
science.org
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...
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Rod Rahimi @rodrahimi.bsky.social · 28/10/2024
Added new folks to the #Immunology Starter Pack 🧪 @sarahdimeloe.bsky.social @mahimaswamy.bsky.social @profken.bsky.social @johannajoyce.bsky.social @alanmcn1.bsky.social @immunoah.bsky.social @bnmelgert.bsky.social @copperbae.bsky.social @benjaminkrishn3.bsky.social go.bsky.app/PY5tCas
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Will Jennings📉🗳️ @drjennings.bsky.social · 20/10/2024
I’m getting tired of the ‘but I have lots of followers on X’ arguments. Lots of them are dead accounts or bots. The algorithm is fixed against you unless you pay. It’s a Nazi swamp. Stay if you’re comfortable with that but if you are generating engagement you are working for Musk.
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Rod Rahimi @rodrahimi.bsky.social · 18/10/2024
So nice to see more people joining Bluesky. #HiSciSky, I’m a physician-scientist focused on airway diseases. My lab studies T cell responses to inhaled, non-infectious antigens, but I love all experimental biology. For those interested in immunology, here’s a Starter Pack go.bsky.app/PY5tCas
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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 09/10/2024
I’ll soon be advertising a research assistant position with project focused on adipose immunology, immunometabolism & sickness behaviour during infection. Ideal for building research experience. Collaborations with teams in Edinburgh & Boston Informal enquiries by email. Please share #Immunosky
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Aydan Szeto @aydanszeto.bsky.social · 02/10/2024
#immunosky IL-4 (& maybe IL-13) are on fire! Last week they were reported to rejuvenate exhausted CAR-T cells, and this week Hans Clevers shows their direct action on human intestinal tufts cells to regenerate the epithelium after damage. www.nature.com/articles/s41...
nature.com
Tuft cells act as regenerative stem cells in the human intestine - Nature
Four distinct tuft cell states are identified by combining analysis of primary human intestinal resection material and organoids, and studying tuft cell development shows that they represent a damage-...
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Aydan Szeto @aydanszeto.bsky.social · 01/10/2024
I am pleased to share our open access review article on the recent (<2 years) discoveries and insights in TH2 cell differentiation and function. www.sciencedirect.com/science/arti...
sciencedirect.com
Molecular mechanisms regulating T helper 2 cell differentiation and function
T helper 2 (TH2) cells orchestrate type 2 immunity during protective antihelminth immunity and help restore tissue homoeostasis. Their misdirected act…
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Rod Rahimi @rodrahimi.bsky.social · 01/10/2024
I haven't seen a starter pack of immunologists, so I created one. Apologies if I overlooked folks. #ImmunoSky 🧪⚕️ go.bsky.app/PY5tCas
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Aydan Szeto @aydanszeto.bsky.social · 15/09/2024
When reviewer 2 asks for a single cell RNA-seq just because we technically could, but adds nothing to the paper
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Aydan Szeto @aydanszeto.bsky.social · 03/09/2024
If my science career doesn’t work out, I would like to write a novel about a naive CD4 T cell. How all it wants to be is like its cousin ILC, but in order to get there it must be selected and activated by the elite gatekeeping APCs.
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Aydan Szeto @aydanszeto.bsky.social · 14/08/2024
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s www.science.org/doi/10.1126/...
science.org
Mef2d potentiates type-2 immune responses and allergic lung inflammation
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevate...
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