The hypothalamus is a central regulator of glucose and energy homeostasis, with arcuate nucleus (ARC) neurons orchestrating these processes. Agouti-related peptide (AgRP) and pro-opiomelanocortin (POM...

Astrocytes are the most numerous brain cells and are central to the regulation of brain metabolism. Here, we present a protocol for identifying molecular signatures and assessing the metabolic functio...

Neuronal vulnerability to ischemic stroke varies markedly across brain regions, yet the mechanisms underlying this selective susceptibility remain poorly understood. Here, we show that the development...

Cell-based and computational platforms have emerged as powerful tools for modelling human biology and disease in physiologically relevant contexts, ...

Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.

From biological and artificial network perspectives, researchers have started acknowledging astrocyt

Combined single-cell transcriptomic and chromatin accessibility sequencing analysis of mouse primary visual cortex across postnatal development reveals that the glucocorticoid receptor drives astrocyt...

Viral vectors delivered through the brain glymphatics achieve widespread targeting of glial cells.

In this review, Sakers et al. discuss how astrocytes, microglia, and oligodendrocyte lineage cells actively regulate neural circuit formation, refinement, and stabilization. They propose that coordina...

Glial cells are fundamental regulators of nervous system function. They orchestrate homeostasis, communication, metabolism, immunity, and repair processes that are essential for sensory transmission, ...