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Dan Arking

@arking.bsky.social
284 followers 82 following 22 posts

Professor of Genetic Medicine, Johns Hopkins University. My lab focuses on genetics of complex human disease.

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Dan Arking @arking.bsky.social · 24/06/2026
Excited to share our latest work showing that mitochondrial variation is causally linked to hematological malignancies and a driver of high risk clonal hematopoiesis of indeterminant potential (CHIP): www.medrxiv.org/content/10.6...
medrxiv.org
Deleterious mitochondrial heteroplasmy drives high-risk clonal hematopoiesis and hematological malignancy
Abstract Mitochondrial DNA (mtDNA) heteroplasmy, the coexistence of multiple mtDNA variants within cells, accumulates with age and is associated with hematological malignancies and mortality. However,...
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American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 23/04/2026
Science advocacy in action! 🧬 ASHG Board members met w/ lawmakers on Capitol Hill to push for $51.303B NIH base budget + key policies impacting research. With proposed cuts to NIH/NSF/ARPA-H, you can add your voice from your state: complete the ASHG Action Alert 👉 bit.ly/4u9YrBe
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Steven Salzberg @stevensalzberg.bsky.social · 29/11/2025
I can't stay quiet about what RFK jr is doing to the CDC and FDA: stevensalzberg.substack.com/p/dont-trust...
stevensalzberg.substack.com
Don't trust the CDC while RFK Jr. is in charge
The HHS secretary, a notorious anti-vaxxer, is now posting his crank views on CDC's website
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Dan Arking @arking.bsky.social · 12/11/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics
Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics Jiaqi Xie φ a, Phyo W. Win φ...
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Steven Salzberg @stevensalzberg.bsky.social · 22/10/2025
Wow indeed. This is a disaster for U.S. science in so many ways. We're losing the future.
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Dan Arking @arking.bsky.social · 16/09/2025
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations | Science www.science.org/doi/10.1126/...
science.org
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations
Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA...
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Dan Arking @arking.bsky.social · 12/06/2025
New work from our group suggesting mitochondrial heteroplasmies are not just due to genetic drift: Deleterious mitochondrial heteroplasmies exhibit increased longitudinal change in variant allele fraction: iScience www.cell.com/iscience/ful...
cell.com
Deleterious mitochondrial heteroplasmies exhibit increased longitudinal change in variant allele fraction
Genetics; Cell biology.
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Michael Hoffman @michaelhoffman.bsky.social · 09/06/2025
I signed. If you dislike what the Trump administration is doing to NIH and science, you should too.
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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 26/05/2025
I have signed this open letter Donald Trump, RFK Jr, Jay Bhattacharya, Marty Makary, Vinay Prasad, Tracy Beth Høeg & the rest of the GOP science leadership is working hard & fast to dismantle the US biomedical enterprise & celebrating the destruction Science is under siege from this kooky crowd
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Carl T. Bergstrom @carlbergstrom.com · 22/05/2025
Harvard today, your institution tomorrow. It's all part of the Project 2025 plan to destroy high education in America. All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.
The Trump administration on Thursday halted Harvard University’s ability to enroll international students, taking aim at a crucial funding source for the nation’s oldest and wealthiest college in a major escalation in the administration’s efforts to pressure the elite school to fall in line with the president’s agenda.
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Cathy Gao-Howard MD MS @catgaohow.bsky.social · 18/05/2025
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
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Dr. Glaucomflecken @glaucomflecken.bsky.social · 11/05/2025
youtube.com/shorts/CuSwN... I made some people big mad with this one
youtube.com
The Dangers of Raw Milk
YouTube video by Dr. Glaucomflecken
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Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · 09/05/2025
🧪 Ranking member Lofgren and 11 other House dems sent a fiery 7-page letter to acting NSF director today "The cancelation of these awards suggests instead that NSF is willing to apply political censorship of awards under direction from President Trump and the DOGE teenagers" Share widely #SaveNSF
democrats-science.house.gov
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James Pirruccello 🎃🦇🧹 @jamespirruccello.com · 22/04/2025
This is an enormous loss: www.whi.org/md/news/whi-...
WHI Funding Announcement (April 21, 2025)
Today, Women’s Health Initiative (WHI) investigators were informed that the Department of Health and Human Services (HHS) will terminate WHI Regional Center (RC) contracts at the end of their current fiscal year (September 2025). The WHI Clinical Coordinating Center (CCC) will continue operations until January 2026, after which time its funding remains uncertain. While written notification has yet to be received, investigators have been advised to expect formal confirmation soon.
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Johns Hopkins University @jhu.edu · 16/04/2025
Did you know? 99% of all new medications resulted from federally-funded university research through #NIH Learn more about #ResearchSavesLives: hub.jhu.edu/research-sav....
An image with a prescription pill bottle. Text on the image reads: 99% of all new medications resulted from federally-funded university research through NIH
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Ellie Wolfe @elliew0lfe.bsky.social · 11/04/2025
BREAKING: More international graduate students at Johns Hopkins University have lost their student visas. The total is now "several dozen," up from around 12. We are the first outlet to report on this, here is what you need to know: www.thebaltimorebanner.com/education/hi...
thebaltimorebanner.com
‘Several dozen’ Johns Hopkins student visas revoked
Days earlier, that number was closer to 12.
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Aaron Shaw @aaronshaw.bsky.social · 09/04/2025
University presidents, the time is now! Unshackle the general counsel's office! File all the lawsuits! Release the faculty upon the op-ed sections! Write to your alumni, parents, and donors! You have nothing to lose but a tiny percentage of your enormous endowments... www.nytimes.com/2025/04/08/u...
nytimes.com
Trump Officials Freeze $1 Billion for Cornell and $790 Million for Northwestern
The funding pause amid civil rights investigations into both universities sharply escalates the Trump administration’s campaign against elite colleges.
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Seema Jayachandran @seema.bsky.social · 02/04/2025
I am proud to have Chris Eisgruber leading my university. He is meeting the moment.
dailyprincetonian.com
In Bloomberg interview, Eisgruber signals that Princeton will not make concessions
University President Christopher Eisgruber ’83 signaled that Princeton would not make concessions to the federal government after news broke that the Trump administration had suspended dozens of the U...
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Nature @nature.com · 01/04/2025
On health economist Jay Bhattacharya’s first day as head of the US National Institutes of Health (NIH), the chiefs of four of the 27 institutes and centres that make up his agency were removed from their posts. go.nature.com/3QZ8GGT
go.nature.com
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
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Johns Hopkins Bloomberg School of Public Health @johnshopkinssph.bsky.social · 21/03/2025
Research Saves Lives. Here at the Johns Hopkins Bloomberg School of Public Health research is about more than just data-it's about people. Every future discovery starts with the work happening now. Read more about our research: hub.jhu.edu/research-sav... youtube.com/shorts/q90oY...
youtube.com
Research Saves Lives. #shorts
YouTube video by Johns Hopkins Bloomberg School of Public Health
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John Greally @greally.bsky.social · 18/03/2025
Difficult to see how this helps human health or medical research. Eric has been an outstanding leader in our genomics community. www.statnews.com/2025/03/17/t...
statnews.com
Eric Green is out as head of National Human Genome Research Institute
The longtime director of the National Human Genome Research Institute is stepping down, as the larger NIH braces for more changes.
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Johns Hopkins Dept of Biostatistics @jhubiostat.bsky.social · 13/03/2025
"A reduction in funding would erode the competitive edge my group has built over decades and will ultimately impact our capacity to make a difference in helping disease prevention in both individual—and population—levels," says @johnshopkinssph.bsky.social Distinguished Professor Nilanjan Chatterjee
hub.jhu.edu
Keep big data in the fight against chronic diseases
Cuts to NIH funding for biostatistical research would erode the United States' competitive edge, hindering the health, economy, and overall security of the nation
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Stella Hurtley @smhsci.bsky.social · 28/02/2025
Join me and Patrick Chinnery, Luca Scorrano, Aleksandra Trifunovic, and Min Jiang for the Westlake - @science.org Online Symposium Wed 28 March 13.00 CET/20.00 China Mitochondria in health and disease us02web.zoom.us/webinar/regi...
us02web.zoom.us
Welcome! You are invited to join the following webinar: 2025 Westlake Science Symposia. After registration, you will receive a confirmation email with information on how to join the webinar.
Mitochondria, the dynamic orchestrators of cellular energy metabolism and signaling, are essential guardians of health. Dysfunction in these organelles underlies a diverse array of pathologies, rangin...
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Lane, actually 🥄⚧️✊ @laneactually.bsky.social · 28/02/2025
Hey DC metro / NoVA / MD folks — let’s get this going!
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Mark Dredze @mdredze.bsky.social · 19/02/2025
Please read and share this excellent FAQ on University indirect costs by my friend @broniatowski.bsky.social He explains why these funds are essential and a critical investment for research in the United States. www.linkedin.com/posts/david-...
linkedin.com
David Broniatowski on LinkedIn: NIH has just announced that it will save $4 billion by capping university… | 61 comments
NIH has just announced that it will save $4 billion by capping university indirect costs on federal grants. Will this actually save money? Bottom line: No. It… | 61 comments on LinkedIn
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Dan Arking @arking.bsky.social · 17/02/2025
Powerful article written by my colleague Steven Salzberg that captures the damage being done to scientific research in this country: stevensalzberg.substack.com/p/the-pointl...
stevensalzberg.substack.com
The pointless destruction of the world's leading scientific and medical research system
No one benefits from this
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Stand Up for Science! @standupforscience.net · 12/02/2025
Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence
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Mike Feigin 🥯 @mikefeigin.bsky.social · 11/02/2025
March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪 Please visit the website and spread the word. www.standupforscience2025.org
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Ardem Patapoutian @ardemp.bskyverified.social · 10/02/2025
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
chng.it
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
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Eric Topol @erictopol.bsky.social · 10/02/2025
How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.
the yield on NIH research for economic activity
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Matt Barber @biobarber.bsky.social · 08/02/2025
Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
nih.gov
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
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Jonathan Pritchard @jkpritch.bsky.social · 24/01/2025
Very excited about this new work from our lab! Explainer thread coming soon @minetoota.bsky.social
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Dan Arking @arking.bsky.social · 24/11/2024
New study from two very talented postdocs @yunsoohong.bsky.social and @sergiuppasca.bsky.social describing how incorporating mitochondrial heteroplasmy into latest CHIP myeloid neoplasm risk predictors identifies ~35% more high-risk individuals with little loss in specificity: rdcu.be/d08yB
rdcu.be
Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms
Nature Communications - The relationship between heteroplasmy and clonal hematopoiesis of indeterminate potential and its association with the incidence of myeloid neoplasms (MN) remains to be...
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Dan Arking @arking.bsky.social · 15/11/2024
Nice work from Nicole Lake and Monkol Lek (with a small contribution from our group): medicalxpress.com/news/2024-11...
medicalxpress.com
Decoding disease: Novel tool helps identify mutations in mitochondrial DNA
Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of se...
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