Excited to share our latest work showing that mitochondrial variation is causally linked to hematological malignancies and a driver of high risk clonal hematopoiesis of indeterminant potential (CHIP):
www.medrxiv.org/content/10.6...
medrxiv.org
Deleterious mitochondrial heteroplasmy drives high-risk clonal hematopoiesis and hematological malignancy
Abstract Mitochondrial DNA (mtDNA) heteroplasmy, the coexistence of multiple mtDNA variants within cells, accumulates with age and is associated with hematological malignancies and mortality. However,...