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James Pirruccello 🌉🇺🇸

@jamespirruccello.com
3.3K followers 2.7K following 3.5K posts

AI slop enjoyer

PostsRepliesMedia
James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 2h
Can someone please explain to me the particular brainrot people seem to have about porting code to Rust when PHP is just right there for you?
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 2h
Does anyone know why Google Titan keys aren't allowed for OpenAI/ChatGPT? (Not referring to the keys with flawed bluetooth security.)
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 14h
In fairness, this Game Genie code does provide a substantial amount of information about my age.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 14h
Disappointing
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 29/09/2026
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 29/09/2026
So OpenAI is saying that Opus-5.5 is the best?
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Reposted by James Pirruccello 🌉🇺🇸
BART @bart.gov · 29/09/2026
BART Police is actively investigating a shooting that occurred on the BART to Antioch transfer platform in Pittsburg. There is no train service between North Concord and Antioch but bus bridges have been established.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 29/09/2026
The Waymo Premium experience.
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Reposted by James Pirruccello 🌉🇺🇸
UCSF @ucsanfrancisco.bsky.social · 26/09/2026
UCSF’s Kevan Shokat, PhD, just won the $1M Stephenson Global Prize for research in pancreatic cancer. He cracked KRAS, a cancer driver long considered “undruggable.” Drugs built on his work now treat lung and pancreatic cancer. ow.ly/UYuY50ZRSXg
Middle-aged man in a blue lab coat smiling while seated in a scientific laboratory setting.Hand wearing black glove holding five small glass vials with various colored liquids, including pink and orange hues.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 26/09/2026
I'm sorry, but if you bring a complex knot tied to an oxcart from Gordium to a job interview, you're disqualified. It's knot hard, people.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 26/09/2026
www.sfchronicle.com/opinion/edit...
sfchronicle.com
Endorsement: Who should replace Nancy Pelosi in Congress? It’s not even a choice
OPINION: The most intriguing thing about the race between Scott Wiener and Connie Chan to fill Nancy Pelosi’s House seat is that it has become a race at all, the editorial board writes.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 26/09/2026
looped transformers
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 26/09/2026
felonybenchmaxxing
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 25/09/2026
I can't corroborate this - my cert looks fine through March 2027. I see the WashU statement (linked below) but it seems like hearsay. research.washu.edu/announcement...
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 25/09/2026
amairica is this anything
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 25/09/2026
Which peer-reviewed medicine articles and guidelines taught OpenEvidence's models python & deep learning?
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Reposted by James Pirruccello 🌉🇺🇸
Emily Moin @emilymoin.com · 25/09/2026
Gift link, and some reactions herein. www.nytimes.com/2026/09/25/o...
nytimes.com
Opinion | Being a Doctor Will Never Be the Same After A.I. (Gift Article)
I’m confident in my mastery over what doctors do — and less confident about my continued mastery of an ever-evolving universe of facts.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 25/09/2026
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 25/09/2026
So like, why was Tim Cook invited to the state dinner? I guess he's the chairman but why not Ternus?
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 25/09/2026
You're telling me this chinchilla is optimal?
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 23/09/2026
I highly encourage people not to give AI slop presentations. Just throw something bad on some slides, it will be much more compelling than a glossy content that you didn't produce. If we want Claude to present, we can generate that at home.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 23/09/2026
www.anthropic.com/news/claude-...
anthropic.com
Claude discovers a novel enzyme system with CRISPR-like repeats
Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 22/09/2026
well hello there
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Reposted by James Pirruccello 🌉🇺🇸
UCSF Cardiology @ucsfcardiology.bsky.social · 22/09/2026
Congratulations, Dr. Ricky Baylis, on receiving the 2026 Hellman Family Clinical-Translational Research Development Award! His project will leverage the #UCSFCardiology Myocarditis Center to advance our understanding of the immunobiology of human myocarditis.
Dr. Richard Baylis
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 22/09/2026
There is a bad interaction between iPhone's swipe-up-to-close mechanism and Waymo's booking mechanism: you can trigger a booking when you are actually trying to swipe-to-close. I had to switch to Apple Pay to avoid these phantom ride requests from automatically completing.
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Reposted by James Pirruccello 🌉🇺🇸
rev. howard arson @theophite.bsky.social · 22/09/2026
i've been waiting for someone to come up with a good explanation of LLMs for laypeople and this is more or less correct. right now we're mostly getting our answers from virtuous pagans but we're working (via RL) on ways to drill to the bottom of Hell and get answers from Satan himself.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 21/09/2026
I woke up this morning with "i'm upping my p-doom, cause the future goes boom" in my head, so let's play this back
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 21/09/2026
JFK Promenade, SF
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 20/09/2026
saweis.net/posts/rsa-89...
saweis.net
RSA-896
A post about RSA-896.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 20/09/2026
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 19/09/2026
If the paper's counterfactual were true—if training on unfiltered generated data from a generative model worked great, and then training on the output of that next model worked even better, etc—it would be surprising. However, that this isn't the case is unsurprising. www.nature.com/articles/s41...
nature.com
AI models collapse when trained on recursively generated data - Nature
 Analysis shows that indiscriminately training generative artificial intelligence on real and generated content, usually done by scraping data from the Internet, can lead to a collapse in th...
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 19/09/2026
www.sfchronicle.com/sf/article/c...
sfchronicle.com
S.F. health inspector shuts down 24/7 Corgi Cafe in Dogpatch
Just weeks after it opened, a city health inspector has shut down the 24/7 Corgi Cafe in the Dogpatch for operating without a valid permit, according to a notice posted on the front door.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 19/09/2026
CC @segyges.bsky.social www.reddit.com/r/SFbitchesw...
reddit.com
From the SFbitcheswithtaste community on Reddit: Beware of AI Sex Cult In SF and Berkeley
Explore this post and more from the SFbitcheswithtaste community
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 18/09/2026
OK
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 18/09/2026
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 18/09/2026
www.wsj.com/tech/ai/hack...
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 18/09/2026
"Reduce Transparency" is very good
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 17/09/2026
Blest Virginia
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 17/09/2026
www.gettyimages.com/detail/news-...
gettyimages.com
US President Donald Trump is seen aboard Air Force One checking a...
US President Donald Trump is seen aboard Air Force One checking a Kennedy Center large printout after landing at Joint Base Andrews, Maryland on September 16, 2026. Trump, who is returning from...
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 16/09/2026
I got access to the Siri Beta on macOS Golden Gate. We are living in the future.
Siri failing to do the most utterly basic thing that a person might commonly ask their computer to do: change the media that is currently playing.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 16/09/2026
www.nih.gov/about-nih/ni...
nih.gov
Statement on the departure of NIH’s All of Us Research Program CEO Dr. Josh Denny
After nearly seven years as Chief Executive Officer of the All of Us Research Program at the National Institutes of Health, Josh Denny, M.D., M.S., will step down on Oct. 31, 2026, to accept a new lea...
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 16/09/2026
The Millennium Prize problems taught me nothing; I knew these agents were powerful when they eliminated my $0.17 recurring AWS bill.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 16/09/2026
I wish us all a very [Bill Ackman-style long tweet rant] during the FOMC press conference today.
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 16/09/2026
Well that's a bit on the nose
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 16/09/2026
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 15/09/2026
oh hey macOS 27 actually indicates when you're connected via ethernet
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 15/09/2026
👀
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 15/09/2026
OK
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 15/09/2026
Anyone ever get good results with JEPA?
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James Pirruccello 🌉🇺🇸 @jamespirruccello.com · 15/09/2026
TIL that Jasper Johns is still alive: en.wikipedia.org/wiki/Jasper_...
en.wikipedia.org
Jasper Johns - Wikipedia
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