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Anjali Hinch

@anjalihinch.bsky.social
1.5K followers 305 following 28 posts

Statistical and Experimental Geneticist @ Oxford University | Henry Dale, Wellcome-Beit & Royal Society Fellow | Group Leader, Dunn School of Pathology, Oxford germlinegenomics.site.ox.ac.uk

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Reposted by Anjali Hinch
Jonathan Pritchard @jkpritch.bsky.social · 09/08/2026
Must-know numbers in human genetics -- As many of you know, I'm writing a free online textbook in human genetics. In this blog post I cover a key skill for genome scientists from that book: how to use mental math to figure out key genome properties. jkpritchard.substack.com/p/on-fermi-p...
jkpritchard.substack.com
On Fermi Problems in Human Genetics
and some very useful numbers about human genomes to get you started!
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Matthew Freeman @mjafreeman.bsky.social · 14/07/2026
Great opportunity alert! @dunnschool.bsky.social has opened its annual call for new PIs looking for sponsorship for early career fellowships. If you think we might provide the scientific environment you need to launch your independent career, we want to hear from you!
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The Dunn School, Oxford @dunnschool.bsky.social · 14/07/2026
Are you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 22nd of September...please share! www.path.ox.ac.uk/work-with-us...
path.ox.ac.uk
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 06/07/2026
The #ListerPrize2027 is a £300,000 flexible fellowship to support outstanding early-career biomedical researchers based in the UK and Ireland. Do you have bold ideas? Could a Prize transform your group? Now open for applications. All details 👉 lister-institute.org.uk/research-pri...
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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 24/06/2026
We are more than delighted to welcome our new #ListerPrize2026 Fellows! These eight inspiring researchers are set to pursue ambitious biomedical science, thanks to our flexible funding. Bravo! 👏 Meet the new #ListerFellows (read thread) and repost ⤵️ lister-institute.org.uk/news/our-lis...
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Molly Przeworski @mollyprz.bsky.social · 16/05/2026
Now Dr. Vanesa Getseva…
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Jonathan Pritchard @jkpritch.bsky.social · 18/05/2026
This is a fantastic mentoring opportunity!
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Anjali Hinch @anjalihinch.bsky.social · 31/03/2026
Meiosis faces a fundamental problem: It must repair hundreds of DNA double-strand breaks while executing a transcriptional programme essential for gamete development. But many of these breaks occur in genes. So how are these two processes reconciled? www.biorxiv.org/content/10.6...
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Matthew Freeman @mjafreeman.bsky.social · 17/10/2025
Yet another outstanding recruit to @dunnschool.bsky.social! Really looking forward to having Alex Borodavka as a new colleague
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The Dunn School, Oxford @dunnschool.bsky.social · 14/10/2025
Congratulations to the Dunn School postdocs starting their independent research groups across the UK, Germany and China 🥳 - Iqbal Dulloo (@iqbaldulloo.bsky.social) - Marion Schuller (@schullerm.bsky.social) - Yongxu Lu - João Monteiro www.path.ox.ac.uk/news-article...
path.ox.ac.uk
Dunn School postdocs start new PI positions - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
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Inigo Martincorena @imartincorena.bsky.social · 09/10/2025
A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
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Anjali Hinch @anjalihinch.bsky.social · 06/10/2025
Emily passed her transfer viva with flying colours! Thanks to her awesome examiners Simon Myers and Nicky Whiffin #ProudPI
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Society for Molecular Biology and Evolution @official-smbe.bsky.social · 01/10/2025
🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open. We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting. 🗓️ Deadline: October 15th More information: smbe2026.org/symposia #SMBE2026
SMBE2026 | Final call for symposia
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Molly Przeworski @mollyprz.bsky.social · 02/09/2025
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...
biorxiv.org
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
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Matthew Freeman @mjafreeman.bsky.social · 10/09/2025
Another exciting opportunity @dunnschool.bsky.social ! Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health Please help us find great applicants
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The Dunn School, Oxford @dunnschool.bsky.social · 08/09/2025
Our PhD studentship programme is officially open; pass it on If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details... Great science and a great environment! www.path.ox.ac.uk/news-article...
path.ox.ac.uk
Applications now open for our PhD studentship programme - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
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Lino Ferreira @linoafferreira.bsky.social · 10/09/2025
Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics! academic.oup.com/genetics/adv... We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
academic.oup.com
Phantom epistasis through the lens of genealogies
Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef
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Yun S. Song @yun-s-song.bsky.social · 11/09/2025
SINGER, our ARG inference method, is finally published and freely available online: doi.org/10.1038/s415... It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
doi.org
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics
SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.
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Scott Keeney @spo11rulz.bsky.social · 16/08/2025
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
sciencedirect.com
Insight into Meiotic DNA End Resection: Mechanisms and Regulation
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…
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The Dunn School, Oxford @dunnschool.bsky.social · 30/07/2025
📣 Applications now open 📣 We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease! Please share! www.path.ox.ac.uk/work-with-us...
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Yun S. Song @yun-s-song.bsky.social · 06/06/2025
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs: probgen2026.github.io Please help spread the news.
probgen2026.github.io
Home - ProbGen 2026
Your Site Description
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Andrew Blackford @andrewblackford.bsky.social · 29/05/2025
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
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Ian Henderson @hendersi.bsky.social · 30/05/2025
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social www.jobs.cam.ac.uk/job/51488/
jobs.cam.ac.uk
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.
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Anjali Hinch @anjalihinch.bsky.social · 30/05/2025
Wonderful talk by Yun today on the present and future of protein and DNA large language models. Spectacular!
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Caroline Wright @carolinefwright.bsky.social · 29/05/2025
Both translational and fundamental curiosity-driven research are needed to fuel the incredible progress we're seeing in genomic medicine; an important message in this article and and some lovely quotes from @sarahlwynn.bsky.social www.ft.com/content/25dd...
ft.com
Curiosity underlies a breakthrough in rare disease
We must recognise and protect the pipelines that lead from research to real-world benefit
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The Dunn School, Oxford @dunnschool.bsky.social · 20/05/2025
Delighted to announce that Prof. Kevin Foster has been elected Fellow of @royalsociety.org! This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities Many congratulations Kevin! Find out more: www.path.ox.ac.uk/news-article...
path.ox.ac.uk
Kevin Foster elected Fellow of the Royal Society - Dunn School
Many congratulations to Kevin for this prestigious honour, recognising his contribution to integrate ecological and evolutionary principles into microbiology to understand the human microbiome and oth...
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Molly Przeworski @mollyprz.bsky.social · 29/04/2025
Amidst all the terrible and terrifying news, so lovely to hear of @jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
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Nature @nature.com · 21/04/2025
Nature research paper: Towards multimodal foundation models in molecular cell biology go.nature.com/3YvGcbJ
go.nature.com
Towards multimodal foundation models in molecular cell biology - Nature
The development of multimodal foundation models, pretrained on diverse omics datasets, to unravel the intricate complexities of molecular cell biology is envisioned.
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The Dunn School, Oxford @dunnschool.bsky.social · 05/03/2025
Tonight at 5.30pm on the BBC! 📺 The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠 www.path.ox.ac.uk/news-article...
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Cat Vicente @catcvicente.bsky.social · 18/02/2025
Come work with me! Great opportunity for an enthusiastic Comms or events professional!
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Oded Rechavi @odedrechavi.bsky.social · 18/02/2025
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
t.co
https://www.biorxiv.org/content/10.1101/2025.02.14.638102v1?ct=
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Federico Teloni @fedeteloni.bsky.social · 12/02/2025
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social! How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair! Read more 👉 doi.org/10.1101/2025.02.10 Follow along for key insights! 🧵
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DNA Topology Lab @dnatopologylab.bsky.social · 07/02/2025
Why do different DNA molecules occupy different places in the nucleus? What drives chromatin compartmentalisation? Read this amazing paper to find out www.science.org/doi/10.1126/... Many congratulations to all the authors of this brilliant work! @rkoszul.bsky.social
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Matthew Freeman @mjafreeman.bsky.social · 06/02/2025
This is a great opportunity for someone interested in comms, event planning, science history, or just working @dunnschool.bsky.social in Oxford.
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MAYosis @mayosis.bsky.social · 31/01/2025
We are deeply sadden by the sudden loss of Scott. He was an astounding mentor and brought so much to the community on top of his excellent science. His legacy will live on #Meiosis4ever
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Jonathan Pritchard @jkpritch.bsky.social · 26/01/2025
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
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Leo Speidel @leospeidel.bsky.social · 23/01/2025
My bluesky debut! One week to the submission deadline for SMBE 2025, Beijing 20-24 July smbe2025.scimeeting.cn @anaignatieva.bsky.social and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.
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Yoav Gilad @ygilad.bsky.social · 17/01/2025
My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen
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The Dunn School, Oxford @dunnschool.bsky.social · 14/01/2025
We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word www.path.ox.ac.uk/vacancy/asso...
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Sarah Aitken @s-j-aitken.bsky.social · 15/01/2025
Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells" www.nature.com/articles/s41...
nature.com
Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature
Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.
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The Dunn School, Oxford @dunnschool.bsky.social · 13/01/2025
A new paper by @tcell.bsky.social and team makes important advances towards improving CAR-T technology! Read the paper here: www.biorxiv.org/content/10.1... Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...
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HunterLab.bsky.social @hunterlab.bsky.social · 10/12/2024
Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland. Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
meetings.embo.org
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
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The Dunn School, Oxford @dunnschool.bsky.social · 07/12/2024
As promised, season's greetings from all of us @dunnschool.bsky.social (and if your building has a rotunda, flaunt it at Christmas)
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Molly Przeworski @mollyprz.bsky.social · 05/12/2024
Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos
precisionmedicine.columbia.edu
Video Library | Precision Medicine
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Anjali Hinch @anjalihinch.bsky.social · 03/12/2024
Hi, can anyone point me to the start-of-the-art crossover and/or non-crossover maps for S. cerevisiae. Many thanks!
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Mitch Guttman @mitchguttman.bsky.social · 27/11/2024
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...
nature.com
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
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Anjali Hinch @anjalihinch.bsky.social · 26/11/2024
Welcome to Bluesky, friends and colleagues from population genetics and meiosis. Great to see you all here!
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Anjali Hinch @anjalihinch.bsky.social · 26/11/2024
A wonderful innovation from an old friend!
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Department of Statistics @oxfordstatistics.bsky.social · 25/11/2024
We have 2 Florence Nightingale Bicentenary Fellow positions now open for applications! 🏢 ID: 176627 📍 Dept. of Stats 📃 Contract: FT, 3yrs 💷 Salary Range: £48.2K - £57.2K/yr ⏲️ Deadline: 06.01.25 12pm UK 💼 Interview: 27.01.2025  🔗 URL: my.corehr.com/pls/uoxrecru...
A square graphic to advertise the new postdoctoral fellowship positions at the Department of Statistics. The text, on the left hand side in white and dark blue against an orange background: "Florence Nightingale Bicentenary Fellow in Statistics. A career development opportunity for post-doctoral researchers. Applications are open. Deadline: 06.01.2025, 12pm GMT. http://www.jobs.ox.ac.uk". On the right hand side, under the department logo, is a cropped version of a portrait of Florence Nightingale in oil paints by Augustus Leopold Egg. Currently held at the National Portrait Gallery.
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