Faithful chromosome segregation during meiosis I requires tight control of interhomolog recombination. In budding yeast, the meiotic chromosome axis, built on Rec8-containing cohesin together with Red...

PhD Project - MSc by Research: Harnessing Transposon Mutagenesis to Dissect Antifungal Drug Resistance in the Fungal “Superbug” Candidozyma auris at University of Aberdeen , listed on Find...

PhD Project - MSc by Research: Does the mis-regulation of the meiotic HORMA-domain protein induce genome instability? at University of Aberdeen , listed on FindAPhD.com

Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…

Activity of the purified SPO11 enzyme reconstituted in cell-free system.

PhD Project - EASTBIO: Characterizing the cellular signaling centre: Birth to death of TORC1-containing signaling endosomes at University of Aberdeen , listed on FindAPhD.com

Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...

SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...