Longitudinal MRI reveals that the cortex becomes relatively thicker years before amyloid positivity is detected on PET, providing insight into the earliest brain changes and potential consequences of ...

Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says longevity researcher Saul Newman.

Abstract. Individual differences in the volumes of brain structures are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains ...

We have a 3-year researcher position for analysing longitudinal brain MRI data in relation to cognitive- and other biomarker data.The shift to a biomarker-based definition of Alzheimer’s disease (AD) ...

Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...

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Across 13 longitudinal studies (3,737 adults), the authors show that brain atrophy parallels memory loss, with a stronger coupling in later life. APOE ε4 increases decline, yet genetic risk does not m...

Across 13 longitudinal studies (3,737 adults), the authors show that brain atrophy parallels memory loss, with a stronger coupling in later life. APOE ε4 increases decline, yet genetic risk does not m...

As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However,...

As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However,...

Alzheimer's disease (AD) is now defined based on its underlying brain pathology, with the presence of amyloid (Aβ) plaques at high enough levels sufficient to warrant a diagnosis in the absence of cog...

In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-li...

Competing explanations account for education’s link to better memory and brain structure in older age. By analyzing more than 400,000 memory scores and over 15,000 MRI scans, we found the association ...

Nature Medicine - In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the...

“Brain age delta” is the difference between age estimated from brain imaging data and actual age. Positive delta in adults is normally interpreted as implying that an individual is aging (or has aged)...