Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…

This book covers diverse aspects of stem cell research and exemplifies some of the developments and improvements in the field.

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

The defining goal of the academic endeavor is to establish a single perfect value that completely summarizes entire careers’ achievements. Such an index wo

Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.

Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulato...

Two physical constraints help explain why cells are so tiny: surface area-to-volume ratios and diffusion. The first article in our new Data Series.

Lodewijk et al. develop a CRISPRa-programmed embryo model using mouse pluripotent cells. By introducing controllable CRISPR activation tools into pluripotent cells, they enabled the efficient generation of a reproducible model. These tools were also used to disrupt developmental pathways, offering a method to study mechanisms of developmental disorders.