iiinova — where your digital self keeps evolving

Adrija Navarro-Traxler @adrijanavarro.bsky.social · 03/04/2025

🚨 New preprint out! “ALG3 is an AKT substrate that links PI3K signaling to N-glycosylation” 👉 doi.org/10.1101/2025.04.01.646556 This is my big PhD paper—years in the making. So proud to finally share. Huge thanks to Alex Toker, Evan Lien, Laura Ghisolfi, and the Toker lab for all the support. 💛

doi.org

The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation

The PI3K/AKT signaling pathway is frequently dysregulated in cancer and controls key cellular processes such as survival, proliferation, metabolism and growth. Protein glycosylation is essential for p...

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Reposted by Adrija Navarro-Traxler

Ludwig Cancer Research @ludwigcancer.bsky.social · 07/01/2025

Ludwig @harvard.edu’s @alextoker.bsky.social discusses his work, what drew him into a life of science and what compels him to contribute to cancer research. youtu.be/IIG5VD8EHB8 #CancerResearch #CancerChat #ImmunoSky

youtu.be

Alex Toker, Ludwig Harvard

YouTube video by Ludwig Cancer Research

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Reposted by Adrija Navarro-Traxler

Johanna Joyce @johannajoyce.bsky.social · 25/11/2024

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

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Reposted by Adrija Navarro-Traxler

Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

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Reposted by Adrija Navarro-Traxler

Alex Toker @alextoker.bsky.social · 20/11/2024

Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪

aacrjournals.org

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...

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Adrija Navarro-Traxler @adrijanavarro.bsky.social · 20/11/2024

It was such a pleasure to organize for Harry the Healer to come to our lab yesterday! Not only did he have the cutest badge, but his calming and healing nature were very helpful in rejuvenating spirits for all our hard working scientists!

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