We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Lab-grown organoids are turbo-charging the study of human brain development and disease.

Neural organoids have been heralded as having huge potential for advancing our knowledge of the brain in several fields. These include exploring the responses of brain tissue to drugs, investigating the effect of specific genetic mutations on neural electrical activity and characterizing how neural systems develop.

Microelectrode array (MEA) recordings of human neural organoids allow for functional studies of brain network development, but these studies are currently limited in throughput. Pavlinek et al. use organoid dissociation to longitudinally study the development of neural networks and the effects of drug treatment, cell line, and cell-type composition.

A new brain organoid system helps reduce unwanted variability and scales up experiments for higher throughput drug testing and genetic research.

Microelectrode array (MEA) recordings of human neural organoids allow for functional studies of brain network development, but these studies are currently limited in throughput. Pavlinek et al. use or...

NIH leadership said the union “should never have been certified,” in an email to the union’s leadership.

The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The authors challenge recent claims that the emergence of consciousness in human brain organoids (HBOs) remains implausible in the near term. Drawing on neuroscientific evidence, developmental paralle...

To conduct scientifically accurate and socially responsible research, think of “sex” as a complex, multifactorial and context-dependent variable.

Nature - With organoids, assembloids and a growing toolkit of bioengineering tricks, scientists are stitching together models of the developing human brain — and pushing the limits of realism and...

Brain organoids have been proposed as suitable human brain model candidates for a variety of applications. However, the lack of appropriate maturation limits the transferability of such functional tools. Here, we present a method to facilitate neuronal maturation by integrating astrocyte-secreted factors into hPSC-derived 2D and 3D neural culture systems. We demonstrate that protein- and nutrient-enriched astrocyte-conditioned medium (ACM) accelerates neuronal differentiation with enlarged neuronal layer and the overproduction of deep-layer cortical neurons. We captured the elevated changes in the functional activity of neuronal networks within ACM-treated organoids using comprehensive electrophysiological recordings. Furthermore, astrocyte-secreted cues can induce lipid droplet accumulation in neural cultures, offering protective effects in neural differentiation to withstand cellular stress. Together, these data indicate the potential of astrocyte secretions to promote neural maturat

Adam PAVLINEK, PostDoc Position | Cited by 62 | of King's College London, London (KCL) | Read 4 publications | Contact Adam PAVLINEK

Model systems continue to offer us tremendous insight, but it’s time for basic researchers to train their sights on the human brain.