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Henry Lee

@citizenlee.bsky.social
607 followers 719 following 77 posts

CEO at Cultivarium. Technobiologist, starting with microbes.

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Henry Lee @citizenlee.bsky.social · 03/02/2026
So you sequenced a billion+ bases. That don’t impress me much. JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
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Henry Lee @citizenlee.bsky.social · 21/01/2026
We scientists were so preoccupied with whether we could send samples out for cheap pooled sequencing, we didn’t stop to think if we should.
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Henry Lee @citizenlee.bsky.social · 20/01/2026
After a few conversations on AI and science this week, I keep coming back to the same point: execution, not ideation, is still the bottleneck. I wrote this up here: open.substack.com/pub/hhlee/p...
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Henry Lee @citizenlee.bsky.social · 12/01/2026
Scientific progress depends less on what problems we prioritize and more on who is allowed to assemble, and under what conditions.
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Alex Crits-Christoph @acritschristoph.bsky.social · 12/11/2025
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic. We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
Figure 2. PET screen results and RB-TnSeq gene fitness results
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Stu Cantrill @stuartcantrill.com · 07/11/2025
Nov 7th is the birthday of both Lise Meitner & Marie Curie. Of the 13 chemical elements named directly after real people (not mythological figures) only two are named after women: meitnerium and curium (the latter of which is named in honour of both Marie & her husband) #chemsky 🧪
A black & white picture of Lise Meitner sat on a chair while holding a book. There is a bookcase in the background A black & white picture of Marie Curie
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Henry Lee @citizenlee.bsky.social · 04/11/2025
Whether you want to industrialize biology or biologize industry, we could use new financing structures. I propose BiBs (Bioindustrial Bucks). www.genengnews.com/industry-ne...
genengnews.com
Bring on the BioIndustrial Bucks: Growing America’s Bioeconomy
Synthetic biology is ready for the next developmental milestone and America’s leadership depends on getting the financing right.
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Viv Goosens @candiedgoose.bsky.social · 25/04/2025
Register for free (www.cultivarium.org/portal) to access their fantastic work and engage with their growing community. Let's diversify our biological models for deeper understanding! (2/2)
cultivarium.org
Portal — Cultivarium
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Viv Goosens @candiedgoose.bsky.social · 25/04/2025
I'm thrilled to finally share that @wellcometrust.bsky.social funding @cultivarium.bsky.social to expand their portal an include more #fungi & #archaea. Already a go-to for bacteria research, as a hub to find info on how to grow and manipulate microbes. (1/2) blog.cultivarium.org/p/fungi-and-...
blog.cultivarium.org
Filaments of the Future
Over the next three years, Cultivarium will weave fungi and archaea into the fabric of a healthier, cleaner, and more resilient world.
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Cultivarium @cultivarium.bsky.social · 24/04/2025
We're gearing up to tackle new kingdoms of life, thanks to generous support from @wellcometrust.bsky.social. Get in touch! Read more on our blog: cultivarium.substack.com/p/fungi-and-...
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Stacey Burns @wentrogue.bsky.social · 08/03/2025
I got your waste, fraud, and abuse right here

CDC plans to study autism, vaccines
Move comes despite strong evidence finding no link between them.
By LENA H. SUN and LAUREN WEBER • The Washington Post
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Jeremy Berg @jeremymberg.bsky.social · 09/03/2025
Bluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/02/2025
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...
science.org
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
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Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Henry Lee @citizenlee.bsky.social · 28/01/2025
We will continue to improve this resource and would like your feedback!
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Henry Lee @citizenlee.bsky.social · 19/01/2025
It’d be more informative for all if all plasmid identities moved to specific sequence definitions (ie Sequence Object Identifier like DOI) instead of taxonomic and self-important naming schemes (ie using our own initials).
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Eduardo Rocha @epcrocha.bsky.social · 01/01/2025
New preprint. Large genomes vibriophages have it all: multiple functions, autonomy (full set of tRNA genes!), anti-defenses, broad host range. Yet, they remain rare, pinpointing the limits of generalists. Great collaboration with @fredoleroux.bsky.social led by Charles Bernard in our lab.
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George Takei @georgetakei.bsky.social · 30/12/2024
I continue to be deeply moved by this statement to the heavens by President Carter.
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Henry Lee @citizenlee.bsky.social · 30/12/2024
Yikes, only ~11% of all PubMed-indexed articles are open-access (~4M out of 37M). Guess all those AGI/ASI BioLLMs and All Pipetting self-driving labs (APSDls - coined it here first) will belong to journals or…knowledge pirates.
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Patrick Monahan @pattymo.com · 24/12/2024
The orc from Return of the King saying “The age of men is over. Now the Jingle Hop has begun.” He is wearing a Santa hat
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Henry Lee @citizenlee.bsky.social · 24/12/2024
Important work that should not be forgotten or diminished.
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Henry Lee @citizenlee.bsky.social · 22/12/2024
It’s the best thing out there.
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Nature Portfolio @natureportfolio.nature.com · 07/12/2024
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. go.nature.com/49of3Mk 🧪
This is figure 4, which shows collateral sensitivity and cross-resistance interactions between and within antibiotic classes.
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Henry Lee @citizenlee.bsky.social · 06/12/2024
We’re making it easier for you to figure out exactly what is and is not possible for your most interesting bacteria.
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Axel Visel @axelvisel.bsky.social · 04/12/2024
BOOSTER, a newly identified orphan gene, supercharges photosynthesis and, when overexpressed, boosts height of poplars by up to 200% (at least in greenhouse) To make it even more interesting, part of the gene seems derived from a poplar fungus-farming ant 🐜 Paper: www.cell.com/developmenta...
Figure from the paper, showing BOOSTER-overexpressing poplar plants that are about twice as tall as the negative controls.  Googly eyes (not from original paper) look at the taller plants.
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Henry Lee @citizenlee.bsky.social · 06/12/2024
Are there any large scale efforts to use pregnancy brain for connectomics and/or remodeling with hormonal programming?
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Henry Lee @citizenlee.bsky.social · 27/11/2024
What’s the best way to pellet cells in deep 96-well plates WITHOUT a giant 3k rcf centrifuge? Mega bonus points if you don’t have to spin… cc @atinygreencell.bsky.social
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Anthony Amend @fungaloha.bsky.social · 26/11/2024
RP PLS! Iʻm hiring 3 postdocs at U Hawaiʻi to study yeast diversity and evolution, marine fungi, and the genomics of microbiomes in experimental foodwebs. All of these projects have existing datasets and LATITUDE to pursue individual interests and "blue sky" ideas www.dropbox.com/scl/fi/5d7u4...
A researcher on a boardwalk in a DANK hawaiian forest on Molokai.
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Henry Lee @citizenlee.bsky.social · 26/11/2024
Can’t wait to read this
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Henry Lee @citizenlee.bsky.social · 22/11/2024
Why did sheaths need to arise? 🤔
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Henry Lee @citizenlee.bsky.social · 22/11/2024
Unfortunate, but we need to know.
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Henry Lee @citizenlee.bsky.social · 21/11/2024
💯
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Henry Lee @citizenlee.bsky.social · 21/11/2024
One must also consider that all DNA-based life forms are already other being’s dank memes.
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Henry Lee @citizenlee.bsky.social · 21/11/2024
Wake up baby, the 1000 page manifesto on naming fungi just dropped, 2024 edition.
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Henry Lee @citizenlee.bsky.social · 21/11/2024
Looking forward to learning the latest on this!
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Henry Lee @citizenlee.bsky.social · 20/11/2024
Growth is so incredible!
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Henry Lee @citizenlee.bsky.social · 20/11/2024
I didn’t open this PDF so what if this preprint is also a hoax?
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Henry Lee @citizenlee.bsky.social · 20/11/2024
Asking for a friend.
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Henry Lee @citizenlee.bsky.social · 20/11/2024
So are we going to discuss abolishing the NIH here or is that type of content strictly for the other platform?
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Henry Lee @citizenlee.bsky.social · 20/11/2024
Fun! Intriguing that transposons are not depleted in plants. When will someone use plants as a bacterial genome minimization tool?
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Henry Lee @citizenlee.bsky.social · 20/11/2024
It’s time to map the holobiomes
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christoph_STCmicrobeblog @christophstc.bsky.social · 16/11/2024
tagging #PhageSky
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Henry Lee @citizenlee.bsky.social · 12/11/2024
Normalize the drugs
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