I miss the honky-tonks, Dairy Queens and 7-Elevens. (You've got it, you've got it.) And as things fell apart, nobody paid much attention.I've had this song running through my head for a few days. It's...

Attending a Nick Jonas show with my kids was an invitation to experience ‘collective effervescence’ – a healing, shared experience

Taken to its logical conclusion, this line of thinking is absurd—and damning.  

The vision of human-level machine intelligence laid out by Alan Turing in the 1950s is now a reality. Eyes unclouded by dread or hype will help us to prepare for what comes next.

When Essex University’s Southend campus opened, it was a message of hope for a ‘left behind’ UK seaside town. Its closure will be felt far beyond its 800 students, some of whom will not get their degr...

Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’ High-profile studies reporting the presence of microplastics throughout the human body have been thrown into doubt by scientists who say the discoveries are probably the result of contamination and false positives. One chemist called the concerns “a bombshell”. Studies claiming to have revealed micro and nanoplastics in the brain, testes, placentas, arteries and elsewhere were reported by media across the world, including the Guardian. There is no doubt that plastic pollution of the natural world is ubiquitous, and present in the food and drink we consume and the air we breathe. But the health damage potentially caused by microplastics and the chemicals they contain is unclear, and an explosion of research has taken off in this area in recent years. Continue reading...

Leckey et al. report novel measures of neurofilament light chain kinetics in the human central nervous system using stable isotope labelling. Translation o

This study by de Araujo Salgado and Krashes reveals how high-fat diets suppress defensive neural circuits, driving riskier foraging in the presence of predation. The findings highlight how high-fat fo...

A team at CABIMER has developed PLAMseq, a technique that for the first time enables the simultaneous identification of chromatin-associated proteins and their precise genomic locations within a singl...

Decision not to hold vote on Israel’s participation comes in spite of several broadcasters calling for its exclusion Ireland, Spain and the Netherlands will boycott next year’s Eurovision after Israel was given the all-clear to compete in next year’s song contest in spite of several participating broadcasters calling for its exclusion. At the general assembly of the European Broadcasting Union, the body that organises the hugely popular international annual singing competition, no vote on Israel’s participation was held. Continue reading...

ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...

The beloved south London club has announced it will shut next year as redevelopment of the site goes ahead. Founder Adrian Jones, DJs and promoters look back

Small study suggests uniQure drug could be first successful treatment for devastating brain disorder

Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

Trump’s dictator-like behaviour is so brazen, so blatant, that paradoxically, we discount it. But now it’s time to call it what it is, says Guardian columnist Jonathan Freedland

Scientists say ‘shocking’ discovery shows rapid cuts in carbon emissions are needed to avoid catastrophic fallout The collapse of a critical Atlantic current can no longer be considered a low-likelihood event, a study has concluded, making deep cuts to fossil fuel emissions even more urgent to avoid the catastrophic impact. The Atlantic meridional overturning circulation (Amoc) is a major part of the global climate system. It brings sun-warmed tropical water to Europe and the Arctic, where it cools and sinks to form a deep return current. The Amoc was already known to be at its weakest in 1,600 years as a result of the climate crisis. Continue reading...

When millions of once-loyal supporters become disillusioned with a party, there can only be one result: electoral disaster, says Guardian columnist Nesrine Malik

Faced with ‘catastrophic financial doom’ in a difficult industry, the Sunderland outfit explain why imitating Jim Morrison is their way to survive

Inner speech is robustly represented in the motor cortex and can be decoded in real time to restore communication to people with paralysis. Unintentional decoding of private inner speech can be preven...

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation a...

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...

Like so many others, I moved from London to Portugal’s capital for the sun, lifestyle – and the tax break. But as tensions rise with struggling locals, many of us are beginning to wonder whether we’re doing more harm than good …

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Newborns will have whole genome sequencing to enable personalised healthcare that predicts and prevents illness

PhD Project - Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London, listed on FindAPhD.com

Musician, who suffered from mental health problems, wrote and produced the 1966 album Pet Sounds – seen by many as the greatest album of all time Brian Wilson, the Beach Boys musician, songwriter and producer who created some of history’s most purely beautiful pop music, has died aged 82. In a post shared on Instagram on Wednesday, Wilson’s family wrote: “We are heartbroken to announce that our beloved father Brian Wilson has passed away. We are at a loss for words right now. Please respect our privacy at this time as our family is grieving. We realize that we are sharing our grief with the world. Love & Mercy.” Continue reading...

A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...