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Aashrith Saraswathibhatla

@aashrith.bsky.social
96 followers 146 following 21 posts

Mechanobiology and biophysics of collective cell behavior. Asst. Prof. at UMN BME. Postdoc - Chaudhuri lab, Stanford; PhD - Notbohm lab, UW Madison; BTech - IITGN

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Reposted by Aashrith Saraswathibhatla
Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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Reposted by Aashrith Saraswathibhatla
Mathis Riehle @mornorse.bsky.social · 23/07/2026
Last week I attended the 6th 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝗼𝗻 𝗠𝗲𝗰𝗵𝗮𝗻𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 #ISMB2026 that was organised as part of SynSci — Synergy for Science 2026 and did some #Sketchnotes along the way; I plan to add the missing ones with time… bio-mat-sketches-mor.blogspot.com/2026/07/2026...
bio-mat-sketches-mor.blogspot.com
2026 International Society for Mechanobiology meeting in Glasgow at SynSci
A visual blog about science and tissue engineering. Based on live doodles/sketchnotes done during talks. Some with an abstract/writeup.
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Reposted by Aashrith Saraswathibhatla
Ankita Jha @ankita13jha.bsky.social · 07/07/2026
Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1
nature.com
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
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Aashrith Saraswathibhatla @aashrith.bsky.social · 07/07/2026
Congrats, Ankita!! Beautiful paper!
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Reposted by Aashrith Saraswathibhatla
Richard Sever @richardsever.bsky.social · 06/07/2026
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
biorxiv.org
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
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Reposted by Aashrith Saraswathibhatla
Pau Guillamat @pauguillamat.bsky.social · 16/04/2026
Just published in @science.org 🚀 By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes. A new platform for tissue engineering and the design of smart active materials! 🫆 www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Aashrith Saraswathibhatla @aashrith.bsky.social · 17/03/2026
My personal high point of #APSSummit2026
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Reposted by Aashrith Saraswathibhatla
Kolade Adebowale Ph.D. @kolade-adebowale.bsky.social · 28/01/2026
New publication alert! We use theory and experiment to demonstrate that glassy adhesion dynamics can predict anomalous migration on viscoelastic substrates. Grateful to have worked with Vivek Sharma, Ze Gong, Ovijit Chaudhuri, and Vivek B Shenoy 🙏 ! www.nature.com/articles/s41...
nature.com
Glassy adhesion dynamics govern transitions between sub-diffusive and super-diffusive cancer cell migration on viscoelastic substrates - Nature Communications
This study introduces glassy adhesion dynamics within a motor–clutch framework, revealing the mechanism by which cellular and extracellular timescales interplay and govern anomalous cancer cell migrat...
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Aashrith Saraswathibhatla @aashrith.bsky.social · 28/01/2026
Congrats!!
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Reposted by Aashrith Saraswathibhatla
Jacky Goetz @goetzjacky.bsky.social · 20/01/2026
💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ? 💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ
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Stig Ove Bøe @stigoveboe.bsky.social · 29/12/2025
Our review article is now available in Annual Review of Condensed Matter Physics: “Full-Integer Topological Defects in Polar Active Matter.” @luizaangheluta.bsky.social @emmalaang.bsky.social doi.org/10.1146/annu...
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Terence Tao @teorth.bsky.social · 18/08/2025
I wrote an op-ed on the world-class STEM research ecosystem in the United States, and how this ecosystem is now under attack on multiple fronts by the current administration: newsletter.ofthebrave.org/p/im-an-awar...
newsletter.ofthebrave.org
I’m an award-winning mathematician. Trump just cut my funding.
The “Mozart of Math” tried to stay out of politics. Then it came for his research.
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Reposted by Aashrith Saraswathibhatla
Daniel J. Cohen (Princeton) @djcohen.bsky.social · 17/09/2025
Best paper title?: “How to make a new nose for someone when it is off entirely and the dog has eaten it”—c.1460 von Pfalzpaint. I talk noses: @npr.org Shortwave (Regina Barber) tinyurl.com/23dvwzmv Video of my nightclub version @oddsalon.bsky.social tinyurl.com/4snnacs3 #storiesmatter (my art)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 09/07/2025
Saraswathibhatla lab is open for business!!
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Reposted by Aashrith Saraswathibhatla
Nimesh Chahare @onenimesa.bsky.social · 03/07/2025
Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling
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Aashrith Saraswathibhatla @aashrith.bsky.social · 10/06/2025
Thank you for highlighting our preprint, Sharvari!! @prelights.bsky.social
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Reposted by Aashrith Saraswathibhatla
Garrett Beeghly, PhD @gbeeghly.bsky.social · 07/04/2025
Preprint alert! Excited to share this manuscript from my PhD which aims to answer an age-old question. Does size matter? For fat cells, or adipocytes, the answer seems to be yes. We found that larger adipocytes promote aggressive behavior in breast cancer cells. 1/5 www.biorxiv.org/content/10.1...
biorxiv.org
Hypertrophic adipocytes increase extracellular vesicle-mediated lipid release and reprogram breast cancer cell metabolism
Obesity worsens cancer-specific survival and all-cause mortality for women diagnosed with breast cancer. Rich in adipose tissue, the breast exhibits increased adipocyte size in obesity, which correlat...
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Barriga Lab @eliasbarrigalab.bsky.social · 07/04/2025
REPOSTING this here just to officially leave "the other place" Our work on the role of endogenous electric fields in guiding collective cell migration during #morphogenesis is out @naturematerials.bsky.social nature.com/articles/s41...
nature.com
Stretch-induced endogenous electric fields drive directed collective cell migration in vivo - Nature Materials
Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.
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Aashrith Saraswathibhatla @aashrith.bsky.social · 09/03/2025
Thank you!
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Jake Song @jakesong15.bsky.social · 18/02/2025
Understanding the physics of our foods can inform the design of future foods - plant-based or otherwise! Check out the article here: www.sciencedirect.com/science/arti...
sciencedirect.com
Non-linear rheology of melted cheddar cheese
The rheology of melted cheese is a fundamental parameter in the preparation of cheese for consumer foods, but remains poorly understood. We show that …
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Aashrith Saraswathibhatla @aashrith.bsky.social · 18/02/2025
Thank you, Jake!
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Reposted by Aashrith Saraswathibhatla
Harmit Singh Malik @harmitmalik.bsky.social · 15/02/2025
Someone awesome in my circle shared some terrific news with me today but was hesitant to do so because of all that is going on in the science world. It may appear insensitive that you are celebrating when other colleagues are struggling but I entreat you to celebrate & share good news. 1/
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Thank you, Jacky! Nice meeting you recently at the GRC.
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Thank you!!
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
I want to thank all the co-authors (particularly Md Foysal Rabbi from Taeyoon Kim's lab), collaborators, and funding sources for all the help! Here is the link to the paper (11/11): biorxiv.org/content/10.1....
biorxiv.org
Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion
In breast cancer (BC), radial alignment of collagen fibers at the tumor-matrix interface facilitates collective invasion of cancer cells into the surrounding stromal matrix, a critical step toward met...
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Finally, using an organotypic model mimicking DCIS, we demonstrate that the basement membrane acts as a mechanical insulator, preventing swirling cells from aligning collagen. Thus, after breaching the BM, swirling of BC cells radially aligns collagen (10/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Using traction deformation microscopy and fiber model simulations, we confirmed our hypothesis of shear-induced radial contractile stresses in collagen-rich ECMs (9/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Based on this, we hypothesized that shear stresses from the swirling motion of cancer cells at the tumor-matrix interface result in radially contractile stresses due to negative normal stress, and such radial stresses, in turn, align col1 radially to facilitate invasion (8/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Interestingly, fibrous networks exhibit the property of negative normal stress, where shear forces generate significant contractile forces perpendicular to the shear direction. This was described by Paul Janmey in 2006 and is similar to shear-normal coupling (7/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
To our surprise, cells migrated tangentially to the tumor-matrix interface in a swirling-like motion. This raised the question: How does the swirling, or tangential, motion of cancer cells at tumor-stroma interface align collagen radially? (6/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Prior to the collective invasion, cells radially aligned collagen at the tumor-matrix interface in a TACS-3-like manner, which enabled their collective invasion (5/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Consistent with our reasoning, increasing mechanical plasticity of collagen-rich ECMs facilitated invasion, with increasing stiffness potentiating a transition from single cell to collective invasion (4/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
We reasoned that mechanical plasticity of collagen-rich ECMs will enable cells to remodel collagen and enable their collective invasion. For this, we characterized the mechanics of human tissues and developed collagen-rich biomaterials that mimicked them (3/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
The radial alignment of collagen fibers (TACS-3) at the tumor-matrix interface is a pathological signature of breast cancer. This was first described by Prof. Paolo Provenzano in late Keely's lab in 2006. However, it is unclear how cancer cells can radially align collagen fibers (2/11)
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Aashrith Saraswathibhatla @aashrith.bsky.social · 14/02/2025
Despite the current uncertainty of being a scientist, I am excited to share our manuscript demonstrating an interesting mechanism of how swirling motion of breast cancer cells align collagen fibers radially at the tumor-stroma interface to enable their invasion (1/11) @thechaudhurilab.bsky.social
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Aashrith Saraswathibhatla @aashrith.bsky.social · 06/02/2025
Our latest paper providing a biophysical mechanism of collagen fiber alignment that enables collective invasion in breast cancer!
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