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Ziyuan Chen

@ziyuanc.bsky.social
93 followers 191 following 2 posts

Single Molecule Tracking. Postdoc at Tjian-Darzacq lab, UC Berkeley. Biophysics PhD with Biteen lab UMICH.

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Reposted by Ziyuan Chen
Surfin' NuRD @surfinnurd.bsky.social · 07/05/2026
"One important implication of our findings is that remodelers are not inherently activating or silencing." --Yeah man. 100% "Instead, remodeler activity can position nucleosomes in configurations that can be exploited by different chromatin modifying enzymes or reader proteins." --interesting idea!
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Reposted by Ziyuan Chen
FPbase @fpbase.org · 04/11/2025
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it! www.fpbase.org/spectra/
fpbase.org
FPbase Fluorescence Spectra Viewer
An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.
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Reposted by Ziyuan Chen
Elisa Zhang, Ph.D. @elisazhang.bsky.social · 24/10/2025
🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩 More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
hhmi.wd1.myworkdayjobs.com
Postdoctoral Scientist - Zhang Lab
Primary Work Address: One Shields Avenue, Davis, CA, 95616 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and s...
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Reposted by Ziyuan Chen
matteomazzocca.bsky.social @matteomazzocca.bsky.social · 14/05/2025
1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
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Reposted by Ziyuan Chen
Teng-Leong Chew @scopeshifu.bsky.social · 13/02/2025
🧪Job opening at Janelia @hhmijanelia.bsky.social Integrative Imaging platform for a bioimage analyst. Please repost.
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Reposted by Ziyuan Chen
Anna-Karin Gustavsson @gustavssonlab.bsky.social · 23/11/2024
Our review on Light sheet illumination in single-molecule localization microscopy for imaging of cellular architectures and molecular dynamics is now published in npj Imaging! Check it out here: doi.org/10.1038/s443...
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Reposted by Ziyuan Chen
Cees Dekker @ceesdekker.bsky.social · 16/01/2025
New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/
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Reposted by Ziyuan Chen
Claus Wilke @clauswilke.com · 17/12/2024
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs. bioart.niaid.nih.gov
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Reposted by Ziyuan Chen
Mike Lee @theleelab.bsky.social · 13/12/2024
We just posted a preprint about a death mechanism that we find truly surprising. When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?! preprint here and a thread (1/n): www.biorxiv.org/content/10.1... 🧪
biorxiv.org
Pol II degradation activates cell death independently from the loss of transcription
Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...
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Reposted by Ziyuan Chen
Julie Biteen @juliebiteenlab.bsky.social · 13/11/2024
Thrilled to share Luis' manuscript showing how bacterial ribonucleoprotein bodies (BR-bodies) control RNA metabolism: stress changes the bacterial biomolecular condensate material state *and* shifts function from mRNA decay to storage. #LiveCell #SingleMolecule #Microscopy @schraderlab.bsky.social
Thrilled to share Luis's manuscript showing how RNA metabolism by bacterial ribonucleoprotein bodies (BR-bodies) is controlled: stress changes the bacterial biomolecular condensate material state *and* shifts function from mRNA decay to storage. #LiveCell #SingleMolecule #Microscopy
 
Proposed model showing how the material state of BR-bodies tunes their activity, enabling a transition from mRNA decay enhancement during growth to storage during stress.
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Reposted by Ziyuan Chen
bioRxivpreprint @biorxivpreprint.bsky.social · 13/11/2024
Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage www.biorxiv.org/content/10.1101/202…
biorxiv.org
Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage https://www.biorxiv.org/content/10.1101/2024.11.12.623272v1
Bacterial ribonucleoprotein bodies (BR-bodies) are dynamic biomolecular condensates that play a pivo
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