#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️.
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
aacrjournals.org
Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
Abstract. Glioblastomas are incurable primary brain tumors that depend on neural-like cellular processes, tumor microtubes (TMs), to invade the brain. TMs also interconnect single tumor cells to a com...