Adherent cells mimic the mechanical properties of their surroundings, becoming stiffer in more rigid environments and softer in more compliant ones. Elbanna et al. find that this environmentally induc...

Learn how a discovery about T cell exhaustion could lead to new ways to boost the effectiveness of immunotherapy.

By screening Lachnospiraceae supernatants using SHAP analysis, Yasuma-Mitobe et al. identify bacteria-derived valeric acid (VA) as an inhibitor of C. parapsilosis growth. VA levels inversely correlate...

Class switch recombination (CSR) enables B cells to diversify antibody effector functions while preserving antigen specificity. This process involves activation-induced cytidine deaminase (AID)–mediat...

Langerhans cells mediate dermal lymphatic growth in early life, which affects lymph node T cell responses in adulthood.

SPP1hi macrophages in synovial fibrin deposits promote tissue hyperplasia in the joints of individuals with rheumatoid arthritis.

The ability to maintain tolerance at mucosal barrier surfaces is critical for immune homeostasis. Yang et al. identify Bhlhe40 as a central regulator linking innate and adaptive intestinal immunity. By coordinating ILC3 effector responses with RORγt⁺ antigen-presenting cells, Bhlhe40 integrates inflammatory and microbial signals to balance tissue protection with tolerance, providing insight into mechanisms relevant to inflammatory bowel disease.

Rapid production of the effector cytokine IFN-γ by natural killer (NK) cells is critical for host defense against viral infection. In activated NK cells, I

A small subset of T cells, called stem T cells, are responsible for making new T cells and for continuously replenishing them in chronic disease, according to a team of scientists from Weill Cornell M...

In settings of persistent antigen, such as autoimmunity and chronic infection, stem-like CD8 T cells sustain antigen-specific immune responses. Here, LEF1 and niche-derived factors are identified as e...

The ability to maintain tolerance at mucosal barrier surfaces is critical for immune homeostasis. Yang et al. identify Bhlhe40 as a central regulator linking innate and adaptive intestinal immunity. B...

On April 20, Weill Cornell Medicine awarded the Pioneers in Diversity Awards, recognizing commitment to diversity and inclusion through mentorship, service and advocacy.

Weill Cornell Graduate School congratulates the graduate students who received award offers in the 2026 National Institutes of Health Individual Predoctoral Fellowship (Parent F31) program.

In the Adams Lab at the University of Rochester Medical Center, we study how dendritic cells of the immune system contribute to immunity and how their dysregulation leads to the development of autoimm...

Primary Work Address: 1275 York Avenue, New York, NY, 10021 Current HHMI Employees, click here to apply via your Workday account. About the Lab The Brown Laboratory studies how the tissue microenviron...

The transcription factor TOX is well studied in the context of CD8⁺ T cell functionality, but less is known about its role in CD4⁺ T cells. Here the authors show that TOX drives TH1 cell differentiati...

Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body’s immune sentinels, are…

Nature - Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones

Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body’s immune sentinels, are…