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Justin Perry - Perry Lab

@justinperryphd.bsky.social
992 followers 1.3K following 105 posts

Scientist @MSKCC | We study dead cell clearance / phagocytosis | #Immunology | #CellBiology | #Metabolism | views my own, not MSKCC. FreeCon Signatory. Alaskan.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · 13/03/2026
You need to register for a free account which is sort of annoying. But this is a little interview on our recent microplastics paper in Live Science. www.livescience.com/health/micro...
livescience.com
Microplastics prevent immune cells from gobbling up germs
Microplastics might clog up immune cells, preventing them from fighting infections and clearing away dead cells, as well as reducing sperm counts.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 07/03/2026
interview: during my visit to CNIC, we discussed some of the lab's work and why it matters, as well as some broader points, like why I find it exciting that we are wrong all of the time. read more here -> www.cnic.es/en/noticias/...
cnic.es
Justin Perry: "In science, we are wrong all the time"
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 24/02/2026
Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 20/12/2025
Perry Lab has published 4 high-profile papers (w/ 5th accepted) in 6 yrs since lab opened yet still can't seem to catch a break/benefit of the doubt at NIH study sections. High-risk research has turned out to be a double-edged sword. I'm now questioning my choices.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 20/09/2025
Yuval Levin: Have an Argument. Disengagement—not disagreement—is the real failure of our politics. www.thefp.com/p/yuval-levi...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 10/09/2025
If you can't say that political violence, especially murdering someone in cold blood because you disagree with them, is not only morally wrong but anathema to a free country, then I would encourage you to immediately log off and take time for self-reflection.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 08/09/2025
I was interviewed by Nick Jahomes on the Mind & Matter podcast about our study in @nature.com. Nick does a great job asking questions & explaining nitty gritty. Please take time to listen to the episode & if you like it, consider supporting Nick's efforts. mindandmatter.substack.com/p/fructose-m...
open.substack.com
Fructose, Microglia, Anxiety & Brain Development | Justin Perry | 249
Cellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 05/09/2025
Here's what I assume the study is in re: acetaminophen. It's a statistical analysis of a few dozen studies, to be clear, where the majority (especially the high quality ones) show a positive association. Reputable investigators. ehjournal.biomedcentral.com/articles/10....
ehjournal.biomedcentral.com
Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - Environmental Health
Background Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 07/08/2025
Congratulations to Ana @anaccodo.bsky.social in my lab and the other awardees. It is a really great acknowledgement of excellent trainees doing cool science.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 26/07/2025
It's official. I'm happy to announce that I have been promoted to Associate Member @mskcancercenter.bsky.social. It is sincere when I say that this would not have been possible w/o the incredible work of the members of my lab. In fact, exciting news about them coming soon. Stay tuned.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 04/07/2025
Today we remember our founding & the principles that this great nation was built on, that although we do not always live up to its ideals, it is those ideals, especially the liberty that pluralism affords, that will remain a beacon of hope for a more perfect union. As Madison wrote in Federalist 10:
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 18/06/2025
New from @masslab.bsky.social @unibonn.bsky.social @immunosens.bsky.social out @natureportfolio.nature.com also shows maternal diet affects offspring macrophage function & disease susceptibility. Mass Lab study: www.nature.com/articles/s41... Our study: rdcu.be/eqx2G
nature.com
Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature
In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 11/06/2025
Out today from The Perry Lab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates directly affects neurodevelopment. In @natureportfolio.nature.com www.nature.com/articles/s41... @mskcancercenter.bsky.social @weillcornell.bsky.social.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 02/06/2025
New study by Alissa Trzeciak in The Perry Lab @mskcancercenter.bsky.social is out! The best way to explain the journey is if I compared it to the Director's Cut of the Lord of the Rings trilogy. Let's just say, it wasn't submitted in March 2025. Link: rdcu.be/eoaRm Writeup: edin.ac/3FtYS5B
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 28/05/2025
Embarrassingly slow to post this, but The Perry Lab @mskcancercenter.bsky.social has graduated its first PhD student! It was a great couple of weeks for Shasha, a @weillcornell.bsky.social IMP student. He received The Schmidt Science Fellowship, had his paper accepted (out soon), and defended!
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 22/04/2025
Excellent and informative Q&A with NIH Director Jay Bhattacharya. Really looking forward to what programs they will come up with, especially (hopefully) expansion of the NIH Director's Office High Risk, High Reward grant programs. If they are looking for ideas, I have a few 🤔.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 16/04/2025
Very honored to be among this group of incredible scientists, including TWO OTHERS from our Immunology Program @weillcornell.bsky.social @wcm-imp.bsky.social, to receive this from @lupusresearch.bsky.social www.lupusresearch.org/lupus-resear... @mskcancercenter.bsky.social
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 06/04/2025
I have the most important talk of my young academic career coming on Monday. So, naturally, my wife & I went to our favorite brewery (Troeg's, 3.5h away) for the special yearly release of our favorite beer. Always remember your priorities.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 02/04/2025
Thrilled to share that PhD student Zhaoquan Wang, pioneer of our fructose metabolism work, has received the prestigious Schmidt Science Fellowship allowing him to pursue exciting questions in the octopus. @weillcornell.bsky.social @mskcancercenter.bsky.social www.prnewswire.com/news-release...
prnewswire.com
From Octopus Intelligence to Smart Artificial Blood Vessels: 2025 Schmidt Science Fellows to Break New Ground with Interdisciplinary Research
/PRNewswire/ -- Thirty-two early career researchers, tackling issues from improving food security to developing better medical implants, were awarded up to two...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 02/04/2025
www.nature.com/articles/s41...
nature.com
Sweet success in CAR T cells - Nature Reviews Cancer
Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 24/03/2025
This sort of slipped under the radar a bit, but we @justinperryphd.bsky.social received the @americancancersoc.bsky.social Research Scholar Grant for our work @mskcancercenter.bsky.social. www.cancer.org/research/acs...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 21/03/2025
Nice work by Grayson Logue in @thedispatchmedia.bsky.social. I was one of the scientists interviewed for the piece. I appreciate the chance to share our story and welcome discussion over how we can improve the NIH moving forward under Dr. Jay Bhattacharya.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 06/03/2025
Super pumped to see how Anya from the lab merges her unique areas of expertise! Highly recommend checking her lab out for training if you're interested in phagocytosis and tick biology.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 02/03/2025
This article by Yuval Levin from the American Enterprise Institute continues to remain apt. Whatever the source of the chaos may be (from the outside or from the inside), the short- and long-term consequences are stark. www.thenewatlantis.com/publications...
thenewatlantis.com
Yuval Levin: The deeper question raised by the NIH grant overhaul
Is the Trump administration’s goal to run the government or oppose it?
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 27/02/2025
Good luck @drjbhattacharya.bsky.social. Looking forward to seeing how you handle the questioning. Confirmation hearing, March 5 at 10AM ET. help.senate.gov/hearings
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 22/02/2025
Nice piece from James Pethokoukis on the ramifications on cutting basic science funding for AEI. www.aei.org/economics/wh...
aei.org
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 15/02/2025
Just had my third straight R01 resubmission go from decent score/close to funded, to worse score/not discussed. The NIH is broken. It's been broken for years. Peer review is also broken. Let's not pretend reform isn't needed.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 12/02/2025
"This is a critical aspect of Marbury that is often overlooked. The Court not only has the power of judicial review of legislation; it also has the power to reject the President’s interpretation of the Constitution." - Justice (then Judge) Kavanaugh, 89 Notre Dame L. Rev. 1907 (2014).
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Reposted by Justin Perry - Perry Lab
The Dispatch @thedispatchmedia.bsky.social · 03/02/2025
Malthusian panic is a way of converting a challenging technical and economic problem into a more digestible moral problem, writes Kevin Williamson:
thedispatch.com
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 28/01/2025
I am continually in awe of the innovative ideas and work being done by members of my lab @mskcancercenter.bsky.social I just come up with the rare dumb idea. They prove me wrong, which leads to even more interesting things. Thank you @damonrunyon.org for acknowledging their work.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 28/01/2025
There are things for people to be worried and upset over, for that I encourage calm engagement with your elected representatives. But I find it very frustrating that people with broad reaches in the academic world are making false claims about what various EOs do & the permanence of these acts.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 28/01/2025
No better time than now to familiarize yourself with Clinton v City of New York, especially the majority opinion joined by sitting SCOTUS member Thomas. I'm sure the Advisory Opinions podcast on @thedispatchmedia.bsky.social will have much more on this soon, including other relevant cases.
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Reposted by Justin Perry - Perry Lab
Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 17/01/2025
1/2: MSK is the first hospital in New York City to offer gene therapy for sickle cell disease and beta thalassemia through its pediatric program, MSK Kids. Learn more: bit.ly/4gUKC3a
bit.ly
MSK Kids: First in New York City Offering Gene Therapy for Sickle Cell Disease and Beta Thalassemia
A Q&A with Jaap-Jan Boelens, MD, PhD, Chief of the Pediatric Transplant and Cellular Therapy Service at MSK.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 12/01/2025
I came to @bsky.app bc I was told it's more #science than noise. But I'm seeing more & more politics & culture war stuff, just from the left. Ironically, I'm seeing more & more science on X. Maybe having both will strike a balance. Fwiw. I still find both apps the best recruitment tool out there.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 12/01/2025
Yep, that's me. There's absolutely no other possible reason why I think classically liberal principles, the free market/free enterprise/private ownership, subsidiarity, Burkean localism, etc other than purely selfish reasons. 🤦‍♂️
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 12/01/2025
"A generation of young people with dementia". Wow. Shocking alarmism on a study where the tiny, self-selective PCS group has far worse self-reported depression, known to affect neuropsych symptoms. PS. inappropriate stats, esp regression on correlated data.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 05/01/2025
Despite the lab's success, due in large part to the wonderful postdocs who took a chance on me, it has become financially unfeasible to maintain the same lab size and scope. Nevertheless, I will always meet with potential postdocs and do my best to help them find science homes.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 05/01/2025
Very, very cool data tracker to follow over the coming months. Will be particularly interesting to line this up with economic impact on these different zones, eg employment data, etc. Will also be interesting to see how traffic, parking, etc change above 60th. congestion-pricing-tracker.com
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 04/01/2025
My prediction: many academics will return to X (or cross-post). Bluesky's algorithm is extremely tilted in favor of people w/ very large follower #s. Plus, I get daily follows by inappropriate accounts (an issue seemingly resolved on X). & I see same papers both places (which makes business sense).
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 04/01/2025
The title is annoyingly alarmist. NIH isn't going anywhere. Its budget has been regularly increased, even under Trump. Yes, inflation and too many applicants per grant is an issue, but NIH remains popular. Reform is absolutely necessary, all my colleagues agree privately; how is an important debate.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 04/01/2025
Congratulations to @anacodo.bsky.social for receiving the (well-deserved in my unbiased opinion) @americanheart.bsky.social Predoctoral Fellowship. Ana is already producing seminal work in the lab. I don't use that word lightly. Can't wait to reveal it to everyone!
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 15/12/2024
Nice interview / article by @stevenstrogatz.com for @quantamagazine.bsky.social. Let me know if you ever want to do a follow-up and talk about "efferocytosis", the phagocytic clearance of dead cells, and other forms of phagocytosis, which are essential & an exciting therapeutic target!
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 12/12/2024
Just now processing what was an AMAZING Boo-Yah Event w/ The V Foundation to support the Stuart Scott Memorial Fund. >$3 million raised in a single day! It was the wonderful work of the V Team, I was just lucky to contribute a tiny portion. Shout-out to the Scott Family. Such wonderful human beings.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 11/12/2024
For those looking for more info on the new NCI funding mechanism to replace the F32 (called K32), here is the new announcement. grants.nih.gov/grants/guide... There's also a version for clinical trials. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-CA-25-017: Notice of Intent to Publish a Funding Opportunity Announcement for Academic Career Excellence (ACE) Award (K32 - Independent Clinical Trial Required)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Intent to Publish a Funding Opportunity Announcement for Academic Career Excellence (ACE) Award (K32 - Indepe...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 11/12/2024
Excited for today's Boo-Yah @thevfoundation.bsky.social event. Honored to be amongst esteemed colleagues for such an important cause.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 08/12/2024
My new piece @thedispatchmedia.bsky.social on the nomination of @drjbhattacharya.bsky.social for director of NIH is out. I tried to reason through what he might achieve alone or w/ Congress. I suspect two words will define his run as director: trust & innovation: thedispatch.com/article/why-...
thedispatch.com
Why Dr. Jay Bhattacharya Is the Right Choice to Reform the NIH
Known for criticizing COVID mandates, he has shown courage in taking on the scientific establishment.
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 08/12/2024
Preprints - Dec. 2024. Early life high fructose exposure disrupts microglia function and impedes neurodevelopment - @wcm-imp.bsky.social PhD student Shasha Wang pubmed.ncbi.nlm.nih.gov/37645894/ WNK1 enforces macrophage lineage fidelity - postdoc Alissa Trzeciak pubmed.ncbi.nlm.nih.gov/37383948/
pubmed.ncbi.nlm.nih.gov
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment - PubMed
Despite the success of fructose as a low-cost food additive, recent epidemiological evidence suggests that high fructose consumption by pregnant mothers or during adolescence is associated with disrup...
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 08/12/2024
@cellmetabolism.bsky.social @cellpress.bsky.social Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments. www.cell.com/cell-metabol... Fun videos from the work! Standard: youtu.be/70a3be6NdKM Hypoxia v1: youtu.be/jhF_kMbRYQU Hypoxia v2: youtu.be/bUR3evaz5jk
youtu.be
Atmospheric Oxygen - Scene6 Cell1
YouTube video by Justin Perry
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Justin Perry - Perry Lab @justinperryphd.bsky.social · 08/12/2024
@naturemetabolism.bsky.social @natureportfolio.bsky.social Broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate rescues homeostatic efferocytosis efficiency in vivo. www.nature.com/articles/s42...
nature.com
Broad-spectrum antibiotics disrupt homeostatic efferocytosis - Nature Metabolism
Saavedra et al. show that broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate is shown to rescue homeostatic efferocy...
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