Head direction (HD) cells are required for spatial orientation. Protocols that combine functional identification with anatomical recovery of single HD neurons remain technically demanding. We present ...

In contrast to current models, inputs from midbrain limbic structures, but not from the hippocampus, are necessary for mammillary body contributions to memory.

A new preprint identifies two distinct populations of CA3 neurons, challenging the view that the hippocampal region is a single network.

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Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

Researchers from the Viney Group in the Department of Pharmacology, along with collaborators from The Center for Systems Neuroscience, Boston University, US, have identified distinct subpopulations of...

Hijazi and Jiang et al. identify distinct head direction (HD) cell subpopulations in the mouse anterodorsal thalamic nucleus, based on the combination of firing patterns, connectivity, and neurochemic...

Chowdhury et al. report the discovery of a 19–45-Hz thalamic oscillation that is present during human wakefulness and REM sleep, but not NREM sleep.

The autism spectrum has widened to the point of collapse, affecting how teachers should support autistic pupils in the classroom, researcher Uta Frith tells Helen Amass

Experts at Oxford are looking at how epilepsy can be prevented, diagnosed and treated, as well as promoting awareness of the condition to reduce stigma and improve quality of life for people with epil...

Peripheral cancer inhibits amyloid pathology and rescues cognition of Alzheimer’s disease through secretion of cystatin-c (Cyst-C), which binds amyloid oligomers and activates TREM2 in microglia and enables microglia to degrade pre-existing plaques.

Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal com...

I knew that a revolution in our understanding of soil could change the world. Then came a eureka moment – and the birth of the Earth Rover Program, says Guardian columnist George Monbiot

Widespread cortical accumulation of misfolded pathological tau proteins (ptau) in the form of paired helical filaments is a major hallmark of Alzheimer’s disease. Subcellular localization of ptau at v...

Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and show dynamic vascular-to-a...

A few days ago, I saw this post on LinkedIn: How does the gut microbiome shape early brain development? That’s what FORM, a new $50 million...

Jane Goodall Institute says ‘tireless advocate’ for natural world died in California during US speaking tour The world-renowned primatologist Jane Goodall has died at the age of 91, her institute has said. The Jane Goodall Institute announced that she had passed away of natural causes while in California as part of a US speaking tour. Continue reading...

What do we know about the causes of autism?

Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The anterodorsal...