Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 18/06/2026Pyrodictium abyssi AbpX reveals a calcium-responsive family of microbial biomatrix proteins that form thermostable hydrogels pubmed.ncbi.nlm.nih.gov/42308048/ #cryoEM 101
Reposted by @vinceconticello.bsky.socialAdrià Sogues @adriasogues.bsky.social · 18/06/2026Meet AbpX, a biomatrix protein from the hyperthermophile Pyrodictium abyssi. It forms Ca²⁺-triggered fibrils via donor strand complementation. Using cryo-EM + X-ray, we built a full lattice model and place AbpX in a new TasA superfamily clade. A very nice collaborative project! tinyurl.com/mryzcz4n 0299
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 10/01/2026De novo design of protein nanoparticles with integrated functional motifs pubmed.ncbi.nlm.nih.gov/41509406/ #cryoEM 011
Reposted by @vinceconticello.bsky.socialAnders Ogechi Hostrup Daugberg @andersohd.bsky.social · 07/12/2025Another fruitful collaboration with the Otzen group 🦠🧫🧬 We looked for curli and Fap operons across the bacterial tree of life (GTDB v226), and found that while Fap operon synteny and FapC repeat numbers are remarkably conserved, the opposite is true for curli operons and csgA! 052
vinceconticello.bsky.social @vinceconticello.bsky.social · 05/01/2026New manuscript alert. Turns out that calcium ion coordination may be a more common mechanism than we initially expected to trigger polymerization of extracellular filaments. @mikesleutel.bsky.social @vikramalva.bsky.social www.biorxiv.org/content/10.6...biorxiv.orgFrom fibril to framework: P. abyssi AbpX illuminates a calcium-responsive family of microbial biomatrix proteins that form thermostable hydrogelsEvolutionary pressure on microbial communities propagating under extreme environmental conditions often results in unique structural adaptations to promote cell survival. Here, we report an investigat... 175
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 31/12/2025Distinct flagellins differentially fine tune biofilm initiation via flagellar stator-associated proteins www.biorxiv.org/content/10.64898/2025.12.30.697036v1 #cryoEM 011
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 19/12/2025Alpha-synuclein fibril structures cluster into distinct classes pubmed.ncbi.nlm.nih.gov/41404791/ #cryoEM 021
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 19/12/2025Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoEM 053
Reposted by @vinceconticello.bsky.socialVikram Alva @vikramalva.bsky.social · 13/12/2025Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉 In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria. www.nature.com/articles/s41... 25616
Reposted by @vinceconticello.bsky.socialbioRxivpreprint @biorxivpreprint.bsky.social · 04/12/2025Type III secretion system effector evolved to be mechanically labile and initiate unfolding from the N-terminus. www.biorxiv.org/content/10.64898/20… 011
Reposted by @vinceconticello.bsky.socialMart Krupovic @mkrupovic.bsky.social · 28/11/2025Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...nature.comWidespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature MicrobiologyEnvironmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction. 27439
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 25/11/2025A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation pubmed.ncbi.nlm.nih.gov/41279714/ #cryoEM 011
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 25/11/2025The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoEM 075
Reposted by @vinceconticello.bsky.socialDave Adams @profdjadams.bsky.social · 25/11/2025Latest work from the group looking at using our functionalised dipeptides for energy storage via a micellar analogue to MOST... www.nature.com/articles/s42...nature.comFunctionalized azobenzenes for micellar solar thermal energy storage as a next-generation MOST system - Communications ChemistryMolecular solar thermal energy storage (MOST) systems employ photoswitchable molecules that absorb sunlight and store energy through reversible isomerization, cyclization or other intramolecular rearr... 151
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 25/11/2025How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes pubmed.ncbi.nlm.nih.gov/41282265/ #cryoEM 121
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 06/11/2025Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 pubmed.ncbi.nlm.nih.gov/41193640/ #cryoEM 011
Reposted by @vinceconticello.bsky.socialTanmay Bharat @tbharat-lab.bsky.social · 07/11/2025An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1... 10387168
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 02/11/2025Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae pubmed.ncbi.nlm.nih.gov/41174224/ #cryoEM 011
Reposted by @vinceconticello.bsky.socialSjors Scheres @sjorsscheres.bsky.social · 29/10/2025We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...mrc.tal.netQuick Check Needed 26457
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 26/10/2025Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis www.biorxiv.org/content/10.1101/2025.10.24.684477v1 #cryoEM 022
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 24/10/2025Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists pubmed.ncbi.nlm.nih.gov/41123416/ #cryoEM 021
vinceconticello.bsky.social @vinceconticello.bsky.social · 20/10/2025This looks pretty cool and unexpected.... www.biorxiv.org/content/10.1...biorxiv.orgA hierarchical nickel organic framework confers high conductivity over long distances in cable bacteriaMulti-cellular cable bacteria have evolved a unique machinery that efficiently transports electrons across centimetre-scale distances. Currents flow through a parallel network of periplasmic fibres, w... 022
Reposted by @vinceconticello.bsky.socialMart Krupovic @mkrupovic.bsky.social · 20/10/2025A nice N&V article by Mike Dyall-Smith on our recent paper ( www.nature.com/articles/s41... ): www.nature.com/articles/s41...nature.comArchaeal symbioses all the way down - Nature MicrobiologyEthiopian salt lakes feature unique microbial communities with nesting layers of symbioses, where haloarchaea and their ultra-small archaeal symbionts are prey to viruses, which are in turn hijacked b... 0336
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 18/10/2025Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency pubmed.ncbi.nlm.nih.gov/41107248/ #cryoEM 001
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 14/10/2025Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae pubmed.ncbi.nlm.nih.gov/41083437/ #cryoEM 021
vinceconticello.bsky.social @vinceconticello.bsky.social · 14/10/2025Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social rdcu.be/eKVlIrdcu.beClient Challenge 042
vinceconticello.bsky.social @vinceconticello.bsky.social · 14/10/2025Molecular Microbiology | Microbiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comType IV Pili‐Associated Secretion of a Biofilm Matrix Protein From Clostridium perfringens That Forms Intermolecular Isopeptide BondsClostridium perfringens produces and secretes a biofilm matrix protein, BsaA, which is in the same family as the Bacillus subtilis TasA matrix protein. In this report, we show that BsaA monomers, unl.... 000
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 02/10/2025CryoSeek identification of glycofibrils with diverse compositions and structural assemblies www.biorxiv.org/content/10.1101/2025.09.30.679562v1 #cryoEM 001
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 03/10/2025Absolute hand determination of glycofibrils from natural sources in cryo-EM www.biorxiv.org/content/10.1101/2025.09.30.679555v1 #cryoEM 011
Reposted by @vinceconticello.bsky.socialSonja-Verena Albers @archaellum.bsky.social · 02/10/2025Look at this nice cover: beautiful archaella, image made by @sshamphavi.bsky.social ! Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab! At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social 27416
Reposted by @vinceconticello.bsky.socialFabio Strati @stratifa.bsky.social · 29/09/2025I’m thrilled to share my latest published manuscript, which summarizes my work in the exciting fields of structural biology and amyloid research. A huge thank you to @meytallandau.bsky.social and the team at @landaulabcssb.bsky.social for their shared efforts doi.org/10.1002/advs...doi.orgStructural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high-resolution... 1158
Reposted by @vinceconticello.bsky.socialcryoEM papers @cryoempapers.bsky.social · 29/09/2025Structural and Functional Versatility of the Amyloidogenic Non-Amidated Variant of the Antimicrobial Peptide Citropin 1.3 pubmed.ncbi.nlm.nih.gov/41016026/ #cryoEM 031
vinceconticello.bsky.social @vinceconticello.bsky.social · 28/09/2025Self‐Assembly of Off‐Target Peptide Sequences: Implications for the Design of Soft Materials - Wang - Small - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comSelf‐Assembly of Off‐Target Peptide Sequences: Implications for the Design of Soft MaterialsFor an ionic complementary peptide, both a truncated peptide and an epimerized peptide can still form gels. Mixing these peptides with the parent FEFEFKFK leads to the formation of new, but different... 000
vinceconticello.bsky.social @vinceconticello.bsky.social · 28/09/2025Filamentous structure of the CotVW complex, the crust proteins of the Bacillus subtilis endospore - Journal of Biological Chemistry www.jbc.org/article/S002... Spore protein assemblies are pretty wild. Nice inspiration for biomaterials design.jbc.orgFilamentous structure of the CotVW complex, the crust proteins of the Bacillus subtilis endosporeThe endospores of Bacillus subtilis are encased in a multilayered protective structure comprising core, cortex, inner and outer coats, and an outermost crust. Among the proteins required for crust for... 032
vinceconticello.bsky.social @vinceconticello.bsky.social · 28/09/2025Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation | Science Advances www.science.org/doi/10.1126/...science.orgStructural basis of Pseudomonas biofilm-forming functional amyloid FapC formationThe structure of FapC reveals how Pseudomonas forms biofilms via a unique β solenoid amyloid fold and dynamic assembly pathway. 000
vinceconticello.bsky.social @vinceconticello.bsky.social · 23/09/2025I missed the original share on this article since I was locked out of my Bluesky account due to algorithmic impotence. Hate when that happens. Really cool structure from @jerryknowsnothing.bsky.social and co-authors. rdcu.be/eHQ1Nrdcu.beA family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosaNature Communications - Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming... 031
Reposted by @vinceconticello.bsky.socialSonja-Verena Albers @archaellum.bsky.social · 17/09/2025Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com www.nature.com/articles/s41... Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.socialnature.comStructure of a functional archaellum in Bacteria of the Chloroflexota phylum - Nature MicrobiologyBona fide gene clusters for archaella are widespread across a bacterial phylum and encode functional motility machinery. 712258
