iiinova — where your digital self keeps evolving

Reposted by Verena Straub

Daan van der Vliet @daanvandervliet.bsky.social · 26/05/2025

Happy to share our new preprint! We analyzed lipid metabolism in a unique cohort of controls, AD patients, and individuals resilient to AD. We found reduced lipid droplets in resilience compared to AD. Interesting finding as more literature converges on an important role for lipid droplets in AD!

biorxiv.org

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer’s disease

Introduction While it has become clear that alterations in lipid metabolism are associated with AD, it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. Methods ...

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Reposted by Verena Straub

Physiological Reports @physrep.bsky.social · 19/05/2025

Due to donor shortages, #liver #transplantation may require use of fatty livers. This #proteomic and #lipoprotein profiling study reports on machine # perfusion under #hyperthermia (40 C) as a potential strategy to improve functionality and use of #fattyliver grafts.

doi.org

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Reposted by Verena Straub

Leiden Science @leidenscience.bsky.social · 25/02/2025

🧠🔬 Researchers at Leiden University have uncovered how the brain's own marijuana travels between nerve cells. 2-AG is transported in fatty vesicles, revealing a novel form of neural communication. This breakthrough could pave the way for new treatments for pain and neurological disorders.

universiteitleiden.nl

Finally solved: how the body's own marijuana spreads through the brain

Since its discovery thirty years ago, it remained a mystery: how does the body’s own marijuana move between nerve cells in the brain? Mario van der Stelt and his research group have now uncovered the ...

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Verena Straub @verenas.bsky.social · 21/02/2025

Our paper is now out in PNAS, a journal that has a history of publishing seminal papers on endocannabinoid transport and therefore is the perfect home for this story: www.pnas.org/doi/10.1073/... Thank you to everyone that has contributed!

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Reposted by Verena Straub

André Nadler @nadlerlab.bsky.social · 31/01/2025

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

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Reposted by Verena Straub

Alice Ting @aliceyting.bsky.social · 04/12/2024

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

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Verena Straub @verenas.bsky.social · 28/11/2024

Fantastic work and a masterclass in multi-omics data integration and visualization 🎨

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Reposted by Verena Straub

Jonathan Rockoff @jonathanrockoff.bsky.social · 27/11/2024

Since leaving his perch in Big Pharma, drug developer extraordinaire Ed Scolnick has sought to find effective treatments for mental-health conditions like bipolar disorder. One reason: He’s trying to help his son.

wsj.com

A Scientist’s Final Quest Is to Find New Schizophrenia Drugs. Will He Live to See Them?

Edward Scolnick led the development of dozens of medicines while at Merck. His current mission pits him against time and the mental illness of millions, including his son.

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Reposted by Verena Straub

Caroline Bartman @cbartman.bsky.social · 19/11/2024

Need more starter packs for haters. “We refuse to propose doing AI in our grants” starter pack “What does the Golgi even do” starter pack

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Verena Straub @verenas.bsky.social · 19/11/2024

Preprint on lipid changes in postmortem AD patient brains and the 5xFAD mouse model. Increased BMP, LPC and LPE levels in amyloidosis. Microglia depletion reduces AA-containing BMP but not LPC and LPE. LPC accumulation is associated with astroglial activation, LPE with oxidative stress

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Verena Straub @verenas.bsky.social · 01/11/2024

So much chemistry history in Heidelberg. I can’t believe I never visited the Bergfriedhof during my time in Heidelberg even though I lived closeby. I guess I was too busy studying in rooms named after the chemists buried there 😅

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Verena Straub @verenas.bsky.social · 04/10/2024

Check out CellEKT, an effort from Joel Rüegger and Berend Gagestein to expand the ligandable kinome for cellular target engagement using chemical proteomics 🎯 Including new broad-spectrum kinase probes www.biorxiv.org/content/10.1...

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Verena Straub @verenas.bsky.social · 27/09/2024

There’s a desperate need for new and better therapies for schizophrenia and other psychiatric disorders so the approval of Cobenfy is great news. Nice thread on its discovery:

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Verena Straub @verenas.bsky.social · 25/09/2024

I’m happy to share that my PhD work is now out on #biorxiv. We propose an ‘on-demand release’ model for the release of the endocannabinoid 2-arachidonoylglycerol in extravellular vesicles (EVs) #lipidtime #neuroskyence #biosky 🔗 www.biorxiv.org/content/10.1... 1/5

biorxiv.org

The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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Verena Straub @verenas.bsky.social · 20/09/2024

Register for the Virtual @chembiotalks.bsky.social next Tuesday (Sep 24th) to hear Joel talk about his amazing PhD work. Registration is free! web.cvent.com/event/7b3b6c...

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Verena Straub @verenas.bsky.social · 07/11/2023

First (I think) evidence of the importance and functional role of PLAAT3 in humans. The authors show that absence of functional PLAAT3 leads to a lipodystrophy syndrome as well as neurological symptoms and are able to link PLAAT3 to PPARγ signalling www.nature.com/articles/s41...

nature.com

Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired...

Homozygous loss-of-function variants in phospholipase A/acyltransferase 3 (PLAAT3) underlie a new lipodystrophy syndrome. Functional studies link PLAAT3 loss with peroxisome proliferator-activated rec...

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Verena Straub @verenas.bsky.social · 26/09/2023

This gives me flashbacks to the quantitative practical I had to do as an undergrad. The gravimetric analysis of nickel was the one I needed the most attempts for I think. It was really tricky to get accurate values after drying this stuff in the oven…. 🧪⚗️

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Reposted by Verena Straub

Virtual ChemBioTalks @chembiotalks.bsky.social · 25/09/2023

We have re-opened the registration for the 3rd Munich-Leiden Virtual ChemBio Talks. Another 250 registrations are now possible. Register for free, if you are interested in our event. events.bizzabo.com/485752/home

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Verena Straub @verenas.bsky.social · 19/09/2023

I’ve officially entered the phase of my PhD where whenever I show up in the lab people comment with ‘Still doing experiments?’

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Verena Straub @verenas.bsky.social · 16/09/2023

Hmmm should I risk it and hope it arrives earlier? I’m in my final year so I can’t really wait until 2050

Inhibitor sold by Sigma with an estimated shipping date in 2050

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Verena Straub @verenas.bsky.social · 08/09/2023

Drop something blue from your gallery

White lighthouse on a small grassy hill in against a blue sky

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