Introduction While it has become clear that alterations in lipid metabolism are associated with AD, it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. Methods ...

Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patients into groups based on patterns of gene expression in white matter glia, suggesting different pathological processes and future personalized therapies.

Multiple sclerosis (MS) is a neuroinflammatory disease characterized by expanding demyelinating lesions, leading to severe and irreversible disability. The mechanisms driving lesion expansion, however...