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verenamutzel.bsky.social

@verenamutzel.bsky.social
62 followers 116 following 0 posts

Postdoc in Luca Giorgetti's lab @ FMI Previously Schulz Lab @MPI-MG

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Miki Ebisuya @ebisuyamiki.bsky.social · 13/08/2026
New paper from the lab! authors.elsevier.com/sd/article/S... We find that protein degradation is broadly slower in human segmentation clock cells than in mouse cells, regardless of the degradation pathway or protein category! 1/
authors.elsevier.com
Systematic differences in protein stability underlie species-specific developmental tempo
Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…
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Reposted by @verenamutzel.bsky.social
nellykanata.bsky.social @nellykanata.bsky.social · 28/07/2026
I am very excited to share the work of my PhD with @eddaschulz.bsky.social, now on BioRxiv! 🎉 🧵⬇️ (1/9) How does the transcription↔️chromatin crosstalk ensure monoallelic expression?
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bioRxivpreprint @biorxivpreprint.bsky.social · 27/07/2026
Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome www.biorxiv.org/content/10.64898/20…
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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 15/07/2026
Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:
doi.org
Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics
Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...
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Bram Verhagen @bramverhagen.bsky.social · 13/05/2026
Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇
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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 13/05/2026
Beautiful new study from @elphegenoralab.bsky.social and Leonid Mirny's lab: Cohesin-bridged encounters mediate enhancer-promoter communication, predicting how enhancer effect scales with genomic distance and - for the first time - how CTCF sites modulate enhancer-promoter communciation! 🧵 below
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
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Edda Schulz @eddaschulz.bsky.social · 20/01/2026
⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out! ➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
link.springer.com
Antisense transcription can induce expression memory via stable promoter repression - Genome Biology
Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...
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