Welcome to Development’s 2021 Subject Collection celebrating the 25th anniversary since the publication of the zebrafish issue. The issue, originally publi

Welcome to Development’s 2021 Subject Collection celebrating the 25th anniversary since the publication of the zebrafish issue. The issue, originally publi

Nature Biomedical Engineering, Published online: 28 January 2026; doi:10.1038/s41551-025-01607-1A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of variants of uncertain significance (VUS) in zebrafish.

A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of vari...

Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

A next-generation cytosine base editor (zTadCBE) and other variants are developed by combining the high-efficiency (TadCBEa) and low-indel (TadCBEMax) architectures, followed by the introduction of z....

The NIH is “reducing animal use in research.” But there is no replacement for animal models.

Nature - Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning

We identify bi-allelic variants in TRMT1, encoding a tRNA-modification enzyme, that cause intellectual disability and developmental delay. Functional studies in human cells and zebrafish provide insig...

More than half of the NIH grant-review meetings that were supposed to take place this year have been cancelled, she says. “Without these meetings happening, nothing can get funded.”

The Company of Biologists is committed to championing positive and progressive discovery.​ The last 100 years has been a period characterised ​​by pioneering discovery.​​ The next 100 years promises t...

The groups that review and decide on grant proposals cannot schedule their meetings because the Trump administration has barred them from posting notices in the Federal Register.

NIH officials said they were given no advance warning and less than an hour to post the memo publicly.