Welcome to Development’s 2021 Subject Collection celebrating the 25th anniversary since the publication of the zebrafish issue. The issue, originally publi

Welcome to Development’s 2021 Subject Collection celebrating the 25th anniversary since the publication of the zebrafish issue. The issue, originally publi

Nature Biomedical Engineering, Published online: 28 January 2026; doi:10.1038/s41551-025-01607-1A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of variants of uncertain significance (VUS) in zebrafish.

A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of vari...

Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

A next-generation cytosine base editor (zTadCBE) and other variants are developed by combining the high-efficiency (TadCBEa) and low-indel (TadCBEMax) architectures, followed by the introduction of z....

The NIH is “reducing animal use in research.” But there is no replacement for animal models.