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twotwotwo.bsky.social

@twotwotwo.bsky.social
226 followers 431 following 1.1K posts
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Luke Ontario @coolhand.bsky.social · 11h
“Individuals in the lowest genetic risk decile with high social burden exhibited prevalence comparable to or exceeding that in the highest genetic risk decile with low social burden.”
cell.com
Considering social risk alongside genetic risk for bipolar disorder in the All of Us Research Program
Polygenic risk scores capture only a fraction of bipolar disorder liability. This multi-ancestry study of 115,275 All of Us participants demonstrates that social risk factors confer substantial explan...
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Rebane @rebane2001.bsky.social · 7h
Discord now supports full ANSI colors! I updated my colored text website to let you use them, as well as create rainbows and gradients and stuff. rebane2001.com/discord-colo...
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public health guy @publichealthguy1.bsky.social · 05/10/2026
the darmok "lemon when a week is has been" meme from star trek tng
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Maxim Raginsky @mraginsky.bsky.social · 02/11/2025
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Good Trailcams @goodtrailcams.bsky.social · 04/10/2026
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twotwotwo.bsky.social @twotwotwo.bsky.social · 04/10/2026
Yep: unintended consequences of well-intentioned things happen, but it turns out aiming for bad things is much worse
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Swizec Teller @swizec.com · 01/10/2026
I love that Apple Health has this feature that lets you track the age of your baby
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Rusty Foster @rusty.todayintabs.com · 01/10/2026
Nothing hits like a couple of good eeles after a little business goddamn
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Erika Hall @erikahall.bsky.social · 01/10/2026
1938 ad for cardboard boxes goes way harder than it needs to
Unity
Men Materials Methods
Coordinated for distinctive paperboard packaging
Container Corporation of America

A giant hand grasps three vector lines  and pills them down into an open box in a black and white poster
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Benjamin @benjaminschneider.ch · 30/09/2026
Werner Herzog will be the last human being whose next word no language model can predict
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P(Doomien) Miller @damienmiller.bsky.social · 30/09/2026
Anthropic may not have intended to write an excellent ad for GLM 5.3, but that's what they did. www.anthropic.com/research/glm... Unlike Mythos, I might actually have a chance at using GLM for defensive research. Anthropic didn't reply to any of my requests for Mythos access for use on OpenSSH.
anthropic.com
GLM-5.3 and the spread of advanced cyber capabilities
GLM-5.3 can autonomously build end-to-end cyber exploits, but unlike other frontier models, it was released without meaningful safeguards to limit misuse.
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wariziles @riziles.bsky.social · 30/09/2026
Sociology, Theology, English and Metaphysics
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Ian Coldwater 🧊🚫 @lookitup.baby · 30/09/2026
BREAKING NEWS: “Do geese see God” is a palindrome
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Sam @samd.bsky.social · 30/09/2026
should be instructive for democrats that Magyar is living up to his promise to prosecute Orban officials for corruption and is continuing to poll extremely highly
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twotwotwo.bsky.social @twotwotwo.bsky.social · 30/09/2026
It's amazing the R Senator was 100% confident he'd made a seasoned lawyer casually perjure himself rather than, you know, the other thing
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alex 🍂 @paracausalex.siren-vibes.ts.net · 27/09/2026
girls arent made of sugar and spice bro thats completely bogus. for starters u forgot the lymbic system
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Doll @dollspace.gay · 26/09/2026
Opponents can make a minority’s rights “controversial” simply by organizing against them. If controversy triggers compulsory balancing, the system lets the existence of opposition determine how firmly it will uphold its own principles.
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Kate @katef.bsky.social · 25/09/2026
gm
achewood "guess who just got yelllled aaaat" strip as a meme, except i have skillfully edited it such that Téodor is singing "guess who just broke prodddd", still with the musical notes
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max power 🌌 @sneptech.bsky.social · 25/09/2026
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Tom Gauld @tomgauld.bsky.social · 24/09/2026
My latest @newscientist.com cartoon. many more here: www.newscientist.com/author/tom-gauld/
Image: A graph with lots of red dots clustered together in a curve. The are all looking upwards at a single red dot wearing sunglasses. 

Caption: Mike was an outlier and would probably be excluded from the study, but all the other data points secretly thought he was really cool.
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cinnamon 🐇 🏳️‍⚧️ @plushie.holdings · 23/09/2026
bro nobody told me about the 허니 바나나 맛 "hbm" chips im rolling biz.chosun.com/en/en-retail...
biz.chosun.com
Seven-Eleven and SK hynix launch honey banana HBM snack chip
Seven-Eleven and SK hynix launch honey banana HBM snack chip
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char stiles @charstiles.bsky.social · 20/09/2026
I made this spreadsheet to impress a hinge date and it didn’t work out so now i made content about it #outkast
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Joseph Simpson @vrhermit.com · 20/09/2026
Apple is so freaking weird. They just casually drop 3D authoring into the preview app on macOS. I can sign annoying PDFs and render a scene with ray tracing for 3D graphics in the same app.
A 3D scene shown in macOS Preview with ray tracing enabled
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twotwotwo.bsky.social @twotwotwo.bsky.social · 20/09/2026
Interesting to think what *could* make funding "work (more) like that." We'd have to get people excited about fusion or understanding high-energy physics.
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decorative gourd @taco.cat · 19/09/2026
me: i don’t understand people who are super interested in the traveling salesperson problem also me: omg so many doors in this precinct
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SMBC Comics @smbccomics.bsky.social · 19/09/2026
This isn't a metaphor. Just a story about a roach. COMIC ◆ www.smbc-comics.com/comic/roach-2 PATREON ◆ www.patreon.com/ZachWeinersm... STORE ◆ smbc-store.myshopify.com
4-panel SMBC comic update. The first panel shows a cartoon little roach happily saying "oh man! The stupid human put food in here. fool!" The next panel shows the roach walking away from a poison trap as he says "I’m gonna give it to everyone!" The third panel shows a human at his computer with a similar expression to that of the cartoon roach. The man says "this stupid company made a controversial ad. How embarrassing for them!" The man then walks away from the computer desk, at an angle reminiscent to the panel where the roach walks away from the poison trap. The man says "better share with all my friends and family so everyone knows which ad not to look at."
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amos @fasterthanli.me · 18/09/2026
that's not a very good wisdom
› fm reply "What is your wisdom?"
YOU HAVE NOT AGREED TO THE APPLE FOUNDATION MODELS CLI LEGAL NOTICE & TERMS.
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Mixmoji 🤖 @mixmoji.pixigeko.com · 18/09/2026
🪂 + 🆗
🪂 + 🆗
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Micah Lee @micahflee.com · 16/09/2026
HaJ3FgupAm8RrDJW3MHgT9X7Ft27eVaD What is that? That's a hard-coded API token that Flock cameras use to identify themselves and get OAuth credentials, which can then be used to talk to Flock's production servers. Like, anyone on the internet can probably do this right now.
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Singularity's Bounty e/CC @catblanketflower.yuwakisa.com · 16/09/2026
Jev weighs in on the Council at Rivendell
Success likelihood (Score, 0 = almost certain to fail, 4 = almost certain to succeed)

┌───────────────────────────────┬───────┬──────┬──────┬──────────┬──────┬────────┬─────────┐
│             Plan              │ Score │ Conf │ Fail │ Unlikely │ Even │ Likely │ Succeed │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Small company, Frodo bears it │ 1.86  │ 0.24 │ 0.03 │ 0.39     │ 0.31 │ 0.25   │ 0.02    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Frodo alone                   │ 0.99  │ 0.45 │ 0.33 │ 0.50     │ 0.05 │ 0.09   │ 0.03    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Bilbo takes it back           │ 0.84  │ 0.49 │ 0.39 │ 0.50     │ 0.03 │ 0.07   │ 0.01    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Eagles to Mount Doom          │ 0.65  │ 0.46 │ 0.51 │ 0.41     │ 0.02 │ 0.05   │ 0.01    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Send it West over the Sea     │ 0.55  │ 0.54 │ 0.55 │ 0.39     │ 0.02 │ 0.03   │ 0.01    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Glorfindel carries it         │ 0.52  │ 0.57 │ 0.56 │ 0.39     │ 0.01 │ 0.03   │ 0.00    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Ring on Aragorn               │ 0.24  │ 0.80 │ 0.78 │ 0.20     │ 0.01 │ 0.01   │ 0.00    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Let the Elves figure it out   │ 0.19  │ 0.84 │ 0.81 │ 0.19     │ 0.00 │ 0.00   │ 0.00    │
├───────────────────────────────┼───────┼──────┼──────┼──────────┼──────┼────────┼─────────┤
│ Army marches on Mordor        │ 0.12  │ 0.90 │ 0.90 │ 0.10     │ 0.00 │ 0.00   │ 0.00    │
├───────────────────────────────┼───────┼──────┼─────…
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Nicolas Dream, PhD @afraidofwasps.bsky.social · 16/09/2026
Don't wanna make you feel old but The War of the Roses ended 539 years ago
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Bryan Cantrill @bcantrill.bsky.social · 13/09/2026
The contagion of fear bcantrill.dtrace.org/2026/09/13/t...
bcantrill.dtrace.org
The contagion of fear | The Observation Deck
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Albert Pinto @70sbachchan.bsky.social · 30/06/2026
LOL. mcdonalds CEO says making burgers at home is moving down a "very dangerous path"
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twotwotwo.bsky.social @twotwotwo.bsky.social · 13/09/2026
Labs mostly look away from the real bad things currently happening in favor of the sci-fi
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Colin @colin-fraser.net · 12/09/2026
Alright here’s what I think about this. For me, this argument is a little bit slippery about what it means for a system to have “a final goal”, and takes for granted that any intelligent system must behave as though it has such a thing. I don’t think this is necessary, and I don’t think LLMs do.
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twotwotwo.bsky.social @twotwotwo.bsky.social · 12/09/2026
it is somehow lost in the wash that these companies trained these things up to be hacking tools presumably to get fat contracts from governments, or maybe just one government, that wanted that in their arsenal
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Siobhán @shibbi.me · 12/09/2026
Damn good point.
Terrence Tao: Until recently, this polite fiction has worked, because human mathematicians knew, possibly subconsciously, to use both childlike and adult skills when solving these problems, even if they might only publicly admit to the latter. But modern Al tools, when directed without such expert supervision, can now be aimed all too easily at the ostensible goals of the field, without any incentive to take the slow, whimsical path. The flag is captured, the goal scored, and the problem is solved; but at the cost of lessons learned, insights gained, collaborations formed, and new targets located.

@fleetingbytes: the terrance tao crashout is something to behold

@no_earthquake: imo a lot of people are deeply misreading this as lamenting the death of personal pleasures in the face of efficient goal-attaining when it's a lament of the death of actual goal-attaining in the face of optimized things-shaped-like-goals-attaining
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Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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twotwotwo.bsky.social @twotwotwo.bsky.social · 11/09/2026
Labs have been claiming the glory for big discoveries by dropping unreadable repositories of automated proof-checker code while doing little to advance the understanding of mathematics terrytao.wordpress.com/2026/09/11/a...
terrytao.wordpress.com
A Severe Misalignment of AI in Mathematics
I am proud to be among the list of 25 initial signatories — all Fields Medallists — to the declaration below, which grew out of discussions between ourselves over the last week. We have…
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Nathan Edwards @grackle.space · 22/09/2025
dudes rock
Tumblr post from every-lemon 
Sep 8

so my spouse is part of a weirdly intense but mostly benign men's workout group that meets at like, 5:30am outside every day, even in winter. they do a lot of burpees and lugging cinder blocks up hills and stuff.
they take turns leading the workouts and tomorrow is his turn. I asked what he was planning. he handed me a sheet of William Carlos William poems from a large stack he'd printed.
I said "what" and he explained, helpfully, "it's a William Carlos William themed workout." I asked what inspired it and he said "l've been planning this for months."
Follow up tumblr post 
every-lemon
Sep 9
it was a smash hit.
a dozen guys showed up (more than usual). spouse brought a red wheelbarrow and they took turns bringing cinder blocks up the hill with it. then they broke up in teams and did a relay with an "icebox" (cooler filled with 40lbs of ice). at the end he opened the cooler to reveal it was full of beach plum lacroix and all the guys cheered. they drank sparkling water as he read 'approach of winter' out loud.
he was home by 6:30am.
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Kuba Suder 🇵🇱🇺🇦 @mackuba.eu · 11/09/2026
ae @aelkus.bsky.social:
there is a fascinating book on the history of demonology that makes point that for much of history demons were conceived as middlemen between people and the supernatural realm that you bargained with to get things done

BeijingPalmer @beijingpalmer.bsky.social:
which book?

Ilan Muskat @calculon.bsky.social:

The C++ Programming Language by Bjarne Stroustrup
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duke-erosennin.bsky.social @duke-erosennin.bsky.social · 10/09/2026
Heard a great line about this (forgot where, unfortunately): "If you can walk 15 minutes to a coffee shop, but the barista has to commute 1 hour to the same coffee shop, you don't live in a 15-minute city, you live in an amusement park."
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twotwotwo.bsky.social @twotwotwo.bsky.social · 10/09/2026
This video makes a fascinating argument that Nintendo was able to do a bunch of unusual stuff because they held on to senior devs www.youtube.com/watch?v=xw56...
youtube.com
Why Tears of the Kingdom's physics are so mind-blowing
YouTube video by Polygon
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aaron 👻🎃💀 @hillenjoyer.myatproto.social · 10/09/2026
on the zelda announcement they kept bringing out guys who were like “when i worked on the original game forty years ago” and that’s the nintendo difference. most game companies would rather die than not fire a guy
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Yours in negritude, Ryan K. Smith @mewefree.bsky.social · 09/09/2026
Lethal Shooter has Ms. Rachel on fire.
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Rachel Cole @rmartincole.bsky.social · 29/01/2024
All reports in this thread are from the collections of Northwestern University's Transportation Library. Materials we've digitized can generally be found in HathiTrust. Learn more and search our catalog here: www.library.northwestern.edu/libraries-co...
Text "United States Department of Agriculture. Transporting Watermelons in Bulk and Bin by Truck." Illustration of a semi truck with a watermelon as its trailer.
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Eugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 09/09/2026
Hey buddy you got any breakthrough proofs you’re working on? No reason, me and my large corporation are just curious
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Ted Underwood @tedunderwood.com · 08/09/2026
I think if you start by taking OpenAI 100% at their word, the phrase "inspired by these rumors" still announces "we did something fairly slimy by trying to scoop priority." Maybe it doesn't read as slimy in the social world they inhabit, but it would in mine.
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garrison @garrison.corporate.fm · 09/09/2026
hindley milner gripe system
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Adam Chalmers @adamchalmers.com · 09/09/2026
hindley milner hype system
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