Using genome editing to trace cell lineages, researchers capture the early history of the mouse embryo in unprecedented detail

Researchers mapped how HIV evolves to escape broadly neutralizing antibodies, revealing recurring routes that could inform antibody combinations therapies.

Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

Genome engineering research led by Jonas Koeppel, developing scalable technologies to design structural variants and study mammalian genome function.

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.

The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

Cis regulatory elements (CREs) interact with their target promoters over long genomic distances and can be identified using chromatin conformation capture (3C) assays. Their regulatory activity can be...

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