Reposted by Tim BusseyBrad Postle @bradpostle.bsky.social · 23/09/2026Ontario peeps! www.eventbrite.ca/e/pavlovs-do...eventbrite.caPavlov's DogzThe Pilot Presents Pavlov's Dogz 174
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 20/07/2026for any followers interested in donating for this great iniative to honour our dear friend, colleague and cardiovascular researcher Dr. Rob Gros crowdfunding.savestation.ca/fundraisers/...crowdfunding.savestation.caThe Dr. Robert Gros HeartSafe FundI'm raising money for a SaveStation to help make our communities #CARDIACSAFE! With less than 10 minutes to save a life from Sudden Cardiac Arrest, we all need the power to take action. Please help me... 043
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 10/07/2026#fluorescencefriday NeuN (gray) and nuclei (red) from the @mind-western.bsky.social team 0305
Reposted by Tim BusseySfN Journals @sfnjournals.bsky.social · 07/06/2026#eNeuro | Effect of Functionally Selective Dopamine D1 Receptor Agonists on Complex Cognitive Processes in a Rodent Touchscreen Operant Chamber Task doi.org/10.1523/ENEURO.0296-25.2026 055
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 01/05/2026happy #fluorescencefriday Compare with last week’s post on APOE3 mice now we have the AD APOE4 model with blood vessels in pink, amyloid in blue and microglia in green. Courtesy of the @mind-western.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social teams 12810
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 12/03/2026Have you heard about MouseBytes? Our date repository for @timbussey.bsky.social @lisasaksida.bsky.social touchscreen datasets is growing. Daniel Palmer just uploaded a several datasets to reach over 27,000 individual 🐁 💪 mousebytes.ca/home Look out for new features coming soonmousebytes.caMouseBytesMouseBytes 0102
Reposted by Tim BusseyStressMarq Biosciences @stressmarq.bsky.social · 11/02/2026Product Citation 🍁 Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy. Paper 🛶 go.nature.com/3LPaC5K Product 🌲 bit.ly/2u9YHV2go.nature.comImpairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy - Translational PsychiatryTranslating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive a... 053
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 13/02/2026#fluorescencedriday First attempt on NeuN labeling (magenta) to quantify the 3D distribution of neurons and interface with blood vessels (yellow) by @shahrzadbahrampour.bsky.social and @nadiahaghbinphd.bsky.social for the @mind-western.bsky.social @neuroak.bsky.social 0163
Reposted by Tim BusseyTRIDENT Preclinical Trials @tridentpct.bsky.social · 07/02/2026Incredible interview with one seriously awesome prof! @liisagalea.bsky.social, the world is so much better for the work you do! 😍💜👏 imsmagazine.com/2026/01/26/n...imsmagazine.com“Not a Bikini”By Rebecca Smythe & Areej Mir 121
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 06/02/2026#fluorescencefriday distribution of microglia in the whole brain 35812
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 30/01/2026#fluorescencefriday 🧠 from AppNL-G-F mouse model triple stained for amyloid beta (Cyan) IBA1 (microglia magenta) and CD31 (blood vessels yellow) thanks to @shahrzadbahrampour.bsky.social @nadiahaghbinphd.bsky.social and @arashsalah.bsky.social @mind-western.bsky.social 14710
Reposted by Tim BusseyLiisa Galea @liisagalea.bsky.social · 11/10/202512 episodes coming out! how lucky am I? I got to interview 🤩 experts in psychiatry, gynecology, global health, nephrology, neuroscience, microbiome, FemTech, charitiable giving, & policy...join us for sometimes intense, but always informative conversations, sprinkled with some laughs along the way! 0203
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 03/10/2025#fluorescencefriday shows the intimate relationship between astrocytes, (cyan) microglia (green) and amyloid plaques (magenta). we find that in APOE4 mice there is much more glia associated with plaques. 0246
Reposted by Tim BusseyCampden Instruments @campdeninstruments.bsky.social · 02/10/2025New series coming up where we highlight Bussey-Saksida Touchscreen Chamber tasks! First is the 4-Choice Gambling Task! This task is used to investigate decision-making which can be implicated in many neurological and psychiatric disorders. To learn more: lnkd.in/dCFcWc3Z 012
Reposted by Tim BusseySamar Rizvi @szrizvi.bsky.social · 25/09/2025#neuroskyence community: If you're working with touchscreen operant systems, touchscreencognition.org is a fantastic resource to check out. You'll find SOPs, training videos, real data examples, forums, and more. And best of all, you can stay updated and connected with the touchscreen community 🧪touchscreencognition.orgTouchscreen Cognition | A virtual space for the world-wide community of touchscreen users, the touchscreen-curious and anyone just interested in improving the standards of behavioural testing. 032
Reposted by Tim BusseyLafayette Instrument @lafayetteic.bsky.social · 25/09/2025Explore @touchscreencog.bsky.social, a global hub for touchscreen users, researchers & enthusiasts! 🔹 Training Videos 🔹 SOPs 🔹 Webinars 🔹 Discussion Forums Refine your research, stay updated, & join the community! TouchScreenCognition.org #BehavioralResearch #TouchscreenTech #Science 031
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 19/09/2025If you are interested in great #fluorescencefriday videos, images and anything microscopy or MRI related follow our new account for the MIND platform @mind-western.bsky.social @neuroak.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social 0144
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 12/09/2025It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company. 1287
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 03/09/2025A blog by Marilene Lopes explaining our latest fidings on STIP1 in early development communities.springernature.com/posts/the-un...communities.springernature.comThe Unexpected Guardian of Early Life 011
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 23/08/2025Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comA Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor DeficitsAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ... 094
Reposted by Tim BusseyRavi Menon @northernthrux.bsky.social · 21/08/2025Ontario’s message to the international world of biotech, medical devices and pharma…we don’t want your money or research partnerships.eara.euThe Dangerous Precedent of Political Interference in Medical Research in CanadaThe European Animal Research Association (EARA) expresses deep concern over recent statements by Ontario Premier Doug Ford regarding biomedical research involving dogs. 053
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 22/08/2025Congratulations 🎉 🥳 to @kateonuska.bsky.social for successfully defending her PhD (co-supervised with Taylor Schmitz). No edits so she can rest for few days. Keep an eye out for Kate as she is one of a kind. 0141
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 15/08/2025Our new interest: blood vessels and amyloid plaque interactions after lecanemab treatment of an ApoE4 AD mouse line #fluorescenceFriday @arashsalah.bsky.social and @shahrzadbahrampour.bsky.social for credits 4278
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 15/08/2025a second rendering for #fluorescencefriday 0114
Reposted by Tim BusseyTouchscreenCognition @touchscreencog.bsky.social · 31/07/2025Thanks to everyone who took the time to visit our booth at #AAIC25! We had a wonderful time and met some amazing people being part of the CIHR Institute of Aging's Canadian Pavilion. Until next year! 063
Reposted by Tim BusseyCzarina Evangelista, PhD @czarevangelista.bsky.social · 30/07/2025Last day of #AAIC25 for the exhibitors! Energy is still high 😎 come by our booth at the Canadian 🇨🇦 Pavilion @touchscreencog.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @maximoprado.bsky.social @pradobsky.bsky.social 072
Reposted by Tim BusseyTouchscreenCognition @touchscreencog.bsky.social · 30/07/2025Great to have all our leaders out supporting the team and young talent at #AAIC25! Shout out to @lisasaksida.bsky.social, @timbussey.bsky.social, @maximoprado.bsky.social, and Vania Prado. 074
Reposted by Tim BusseyTouchscreenCognition @touchscreencog.bsky.social · 29/07/2025So much talent from @westernu.ca presenting their cognition and Alzheimer's research at #AAIC25! We are very proud of all of their hard work. Read full abstracts here: touchscreencognition.org/aaic-2025/ 063
Reposted by Tim BusseyLafayette Instrument @lafayetteic.bsky.social · 15/07/2025Touchscreen-based assessments are transforming our understanding of brain regulation in complex behaviors. Piantadosi et al. (2025) published a guide about experimental design and essential hardware modifications for specialized research. Check it out: www.nature.com/articles/s41... 183
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 29/07/2025Check out our posters on Tuesday #AAIC. Learn about new mouse models in which we replaced mouse alpha synuclein with human gene, touchscreen testing in AD mice and ApoE4. 021
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 29/07/2025If you are interested in learning the limitations of current models of alpha synuclein pathology and why we need new KI humanized mouse models check out Latiyah’s poster #AAIC25 Poster 200 Characterization of mouse of Synucleinopathies @tridentpct.bsky.social @touchscreencog.bsky.social 0124
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 24/07/2025Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...nature.comCharacterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling - Lab AnimalThis study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytes’ role in neuroinflammation and cognition without the use of viral transduction, mitigating the potentia... 0114
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 28/07/2025the MouseTRAP team will be presenting the following posters at #AAIC25 today. Come say high and learn how we are using translational approaches to better understand proteinopathies. @touchscreencog.bsky.social @tridentpct.bsky.social 062
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 28/07/2025Get some swag plus strawberry milkshake at our booths in the Canadian Pavillion @touchscreencog.bsky.social @tridentpct.bsky.social and learn more about translational approaches to cognition, how well 🐁 can perform in touchscreen tasks #AAIC25 082
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 28/07/2025Hey #AAIC25 check out Arash’s presentation today at 8 AM and see some cool whole brain videos of the vasculaturs and plaques plus touchscreen testing room 106 Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models also poster 151 0297
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 28/07/2025If you you interested in translational research #AAIC25 and improved rigour in cognitive testing check out the 🐁 2 🧍 approaches to test cognition in identical ways in mice and humans. @touchscreencog.bsky.social get some swag at the Canadian Pavilion. 063
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 27/07/2025The MouseTRAP team @touchscreencog.bsky.social @tridentpct.bsky.social presentations at #AAIC25 If you are interested in translating results from basic to clinical research come for a chat. 094
Reposted by Tim BusseyRavi Menon @northernthrux.bsky.social · 27/07/2025Why does TRIDENT have strawberry milkshakes at its booth at #AAIC2025 ? Listen to Sarah explain the scientific reasons. 062
Reposted by Tim BusseyTRIDENT Preclinical Trials @tridentpct.bsky.social · 27/07/2025Look at this world-class crew! 😍 So excited to see resident TRIDENT experts @maximoprado.bsky.social and Dr. Vania Prado stop by and say hi! #AAIC25 #NFRF 0136
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 27/07/2025come by @tridentpct.bsky.social and @touchscreencog.bsky.social #AAIC25 and get your free strawberry milkshake (just the ones out mice get when they do their touchscreen tasks). Learn about touchscreen testing in mice and humans and the TRIDENT pipeline. 042
Reposted by Tim BusseyCzarina Evangelista, PhD @czarevangelista.bsky.social · 28/07/2025Great 1st day at #AAIC25! We're here for the rest of the week, stop by our @touchscreencog.bsky.social booth that's located in the Canadian Pavilion. 🎉 @maximoprado.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @tcnlab.bsky.social @pradobsky.bsky.social 0164
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 11/07/2025#fluorescencefriday blood vessels and amyloid plaques in a 🐭 model of AD. courtesy of @shahrzadbahrampour.bsky.social Luke Smolders and Arash Salahinejad @tridentpct.bsky.social @touchscreencog.bsky.social We will be 🔜 opening up for external services and collaborations via MIND @westernu.ca 2499
Reposted by Tim BusseyTRIDENT Preclinical Trials @tridentpct.bsky.social · 19/06/2025We have a Newsletter! Hear about all the cutting-edge research at TRIDENT...direct to your inbox! Check out Synaptozone, the TRIDENT E-Newsletter Spring 2025 edition via the link below! #TRIDENT createsend.com/t/y-E25C42E0... To subscribe see the link here: confirmsubscription.com/h/y/6B03FD42... 053
Reposted by Tim BusseyRavi Menon @northernthrux.bsky.social · 04/07/2025@tridentpct.bsky.social was pleased to welcome MP Lianne Rood and her Constituency Assistant Kim Heathcote to tour TRIDENT facilities with @maximoprado.bsky.social (MouseTRAP), @stefan-everling.bsky.social (marmoset), me (@cfmm.bsky.social) and @jackiesullivan.bsky.social (open science). So engaged! 082
Reposted by Tim BusseyTouchscreenCognition @touchscreencog.bsky.social · 18/06/2025Congratulations to Samina Panjwani on successfully defending her Masters thesis at @westernu.bsky.social today! Amazing work! @timbussey.bsky.social @lisasaksida.bsky.social @maximoprado.bsky.social 092
Reposted by Tim BusseyLiisa Galea @liisagalea.bsky.social · 16/06/2025Our latest review on perimenopause menopause and hormone therapy. What key issues have we missed and how can we do better from education to research to clinical care. With Laura Gravelsins! www.cambridge.org/core/journal...cambridge.orgOne size does not fit all: how type of menopause and hormone therapy matters for brain health | The British Journal of Psychiatry | Cambridge CoreOne size does not fit all: how type of menopause and hormone therapy matters for brain health 0115
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 13/06/2025For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social 35220
Reposted by Tim BusseyPaul Sheppard 🧠 @paulsheppard.bsky.social · 02/06/2025🚨 NEW PAPER ALERT 🚨 🚨 KLAXON KLAXON 🚨 Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comImpaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of AmyloidopathyThe amyloid precursor protein knock-in mouse model of amyloidopathy (AppNL-G-F/NL-G-F) was assessed on touchscreen-based learning and cognitive flexibility tasks in comparison with both AppNL/NL and .... 3102
Reposted by Tim BusseyMarco A. Maximo Prado @maximoprado.bsky.social · 30/05/2025#fluorescencefriday a 🧠 full of amyloid courtesy of @shahrzadbahrampour.bsky.social 0236
Reposted by Tim BusseyWestern BrainsCAN @westernubrainscan.bsky.social · 27/05/2025Well done to all of our affiliated presenters at this year's @canacn.bsky.social Meeting! Great work! 093
