Reposted by @kateonuska.bsky.socialVeronica Diveica @veronicadiveica.bsky.social · 14/07/2026The default network is often thought to interfere with the selective deployment of attention—but our new @pnas.org paper shows a different story… 👉 Find the paper here: doi.org/10.1073/pnas... 1/🧵 2427
kateonuska.bsky.social @kateonuska.bsky.social · 19/06/2026Heading into #ISCM2026, we are excited to share that our review is now out in @alzdemjournals.bsky.social! We synthesize evidence across several fields of neuroscience to present a lifespan staging model of basal forebrain cholinergic neuronal (BFCN) vulnerability doi.org/10.1002/alz.... (1/4)doi.orgA lifespan staging model of basal forebrain cholinergic vulnerabilityThe cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age- and Alzheimer's disease-related dysfunction and neurodegeneration. However, the biological bases of bas.... 131
kateonuska.bsky.social @kateonuska.bsky.social · 04/05/2026@northernthrux.bsky.social with a timely Feindel lecture opening! #gohabsgo 161
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 19/03/2026fire away @kateonuska.bsky.social #adpd2026 041
Reposted by @kateonuska.bsky.socialAlfie Wearn @alfiewearn.bsky.social · 10/03/2026Neuromodulatory neurons are extremely susceptible to stress. I argue that their fragility is an inherent weak point, the breaking of which directly leads to Alzheimer’s Disease. I discuss this idea and its implications in a recently published perspective piece: dx.doi.org/10.1002/alz....dx.doi.orgThe neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesisSporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factor... 175
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 23/08/2025Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comA Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor DeficitsAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ... 094
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 24/07/2025Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...nature.comCharacterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling - Lab AnimalThis study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytes’ role in neuroinflammation and cognition without the use of viral transduction, mitigating the potentia... 0114
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 13/06/2025Grad student extraordinaire @kateonuska.bsky.social dropped this preprint www.biorxiv.org/content/10.1... using multimodal imaging, behavior, 🐁 and human datasets to show how cholinergic plasticity regulates resilience to Alzheimer’s pathology. Led by Taylor Schmitz 🧪biorxiv.orgCholinergic synaptic plasticity shapes resilience and vulnerability to tauSynaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Yet due to their plasticity, synapses may also adapt to early AD pathology. Using within-subject positron emission tomography scans targ... 1142
