Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...

The amyloid precursor protein knock-in mouse model of amyloidopathy (AppNL-G-F/NL-G-F) was assessed on touchscreen-based learning and cognitive flexibility tasks in comparison with both AppNL/NL and ....

This protocol extension enables researchers to integrate optically based manipulation and measurement techniques into their touchscreen experimental systems, focusing on optogenetic manipulation, fibe...

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators

Scientific Reports - Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber

Past Issues 29.1 In this issue, our prose takes us from the depths of space to the intricacies of family relationships, and grounds us through meditation retreats. Our poetry is equally thoughtful …

A major obstacle in the pre-clinical study of mood-related disorders and novel affective state therapeutic evaluation is the lack of animal models that fully recapitulate human symptomatology. In this...

Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...

16 track album

16 track album

Rodent behavioural testing paradigms in touchscreen operant chambers have successfully provided insight into the neural mechanisms underlying various cognitive domains in healthy and disease models. T...