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Tiago Beites

@tiagobeites.bsky.social
818 followers 785 following 35 posts

Assistant Researcher | #Tuberculosis research | i3S - University of Porto 🇵🇹 | former Ehrt Lab Weill Cornell Medicine 🇺🇸

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Tiago Beites @tiagobeites.bsky.social · 20/04/2026
How does Mycobacterium tuberculosis safely eat an antimicrobial (host-derived long-chain fatty acids)? Here we show that it’s not through a dedicated mechanism but rather by fine tuning its metabolism. www.nature.com/articles/s42...
nature.com
Mycobacterium tuberculosis long-chain fatty acid resistome reveals universal stress protein TB15.3 as essential for infection - Communications Biology
A genetic screen identifies long-chain fatty acid resistance mechanisms in Mycobacterium tuberculosis, and highlights a universal stress protein required for balanced long-chain fatty acid degradation...
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Tiago Beites @tiagobeites.bsky.social · 13/03/2026
A snip of the idea behind TRICK-TB, a project in collaboration with my good friend @robertsjansen.bsky.social funded by @caixaresearch.bsky.social @i3suporto.bsky.social (Interview in Portuguese/ Robert’s contributions in English) www.saudemais.tv/video/412549...
saudemais.tv
Saúde +
Ciência Agora - T02 E010 - Sandra Cardoso Oliveira
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Tiago Beites @tiagobeites.bsky.social · 07/12/2025
Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies. journals.plos.org/plospathogen...
journals.plos.org
Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host
Redundancy in biology is, at a glance, counterintuitive because if the function of two gene products completely overlaps then, throughout the course of evolution, one of the genes will likely accumula...
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Tiago Beites @tiagobeites.bsky.social · 31/10/2025
An excellent summary of what we’re doing in the scope of our @caixaresearch.bsky.social project TRICK-TB funded by Fundación ”la Caixa”, together with some personal notes. Thank you to Observador for highlighting Portuguese science. [interview in Portuguese] observador.pt/especiais/o-...
observador.pt
O cientista que está a reinventar o tratamento da tuberculose
No Instituto de Investigação e Inovação em Saúde, no Porto, Tiago Beites quer forçar o bacilo da tuberculose a provar o seu próprio veneno. O objetivo? Melhorar o tratamento contra a doença.
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Tiago Beites @tiagobeites.bsky.social · 29/09/2025
Congratulations @alexandregouzy.bsky.social and @pierresantucci.bsky.social!!
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Tiago Beites @tiagobeites.bsky.social · 01/08/2025
Our favorite technician @alexjpinto.bsky.social just got awarded with a PhD fellowship. Here’s to 4 years of exciting research in our team 🥂
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ISSD lab _ i3S @issdlab.bsky.social · 01/07/2025
📣 Save the date: III ERA Chair #ImmunoHUB Annual Meeting! 📅 December 5 🔗 immunohub.i3s.up.pt/iii-immunohub-… ‼️Stay tuned for more info!
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The Freundlich Group @freundlichgroup.bsky.social · 25/05/2025
Please consider passing around this very informative interview to everyone you know (especially non-scientists). I believe it does an excellent job explaining why taxpayers benefit from the federal government’s support of scientific research. www.pbs.org/video/breakt...
pbs.org
Amanpour and Company | Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Season 2025
David Liu joins the show.
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John Green @johngreensbluesky.bsky.social · 10/03/2025
As the U.S. Government endeavors to make tuberculosis great again, please consider preordering a signed copy of my book about our deadliest infection, its long history, and why in the 75 years since TB became curable, we've allowed over 150,000,000 people to die of the disease. everythingistb.com
cover of my new book everything is tuberculosis: the history and persistence of our deadliest infection
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Tiago Beites @tiagobeites.bsky.social · 22/05/2025
Authoritarians promising to protect free speech and then acting like authoritarians. Who would expect that?
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John Rubinstein @johnrubinstein.bsky.social · 16/05/2025
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...
A) Diagram showing how EtfD transfers electrons from beta oxidation to the menaquinol pool in the membrane, linking beta oxidation to oxidative phosphorylation in mycobacteria.
B) A growth curve showing the Mycobacterium smegmatis lacking EtfD can grow when glucose is provided as the carbon source, but has a slight growth delay. Complementing the ∆etfD strain with M. tuberculosis on a plasmid rescues the defect.
C) A growth curve showing that ∆etfD M. smegmatis cannot grow on medium where the fatty acid oleic acid is the only carbon source. A plasmid with with M. tuberculosis EtfD rescues the defect.
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Tiago Beites @tiagobeites.bsky.social · 15/04/2025
Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source. www.biorxiv.org/content/10.1...
biorxiv.org
The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection
The human pathogen Mycobacterium tuberculosis (Mtb) thrives in lipid-rich microenvironments. Long-chain fatty acids (LCFA) are some of the most abundant lipids encountered by Mtb during infection. Mtb...
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Tom Scriba @tomscriba.bsky.social · 24/03/2025
Today is the 24th of March and it's World TB Day. We typically have many activities to educate and raise awareness about TB and how important it is for us all to commit to doing more to end TB! This year feels different though.
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John Green @johngreensbluesky.bsky.social · 24/03/2025
For World TB Day, PIH is hosting a webinar at 12pm EST to discuss the repercussions of recently slashed US foreign aid and the hope that remains. #worldTBday @partnersinhealth.bsky.social Register here: act.pih.org/worldtbday2025
act.pih.org
Register | Turmoil, TB Care, & Taking Action
Join experts on World TB Day to discuss the history, innovations, and social justice impact of TB, the world’s deadliest infectious disease.
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Tiago Beites @tiagobeites.bsky.social · 24/03/2025
In this current political environment it is more important than ever to highlight the #WorldTBday. Let’s keep bending the arc.
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Tiago Beites @tiagobeites.bsky.social · 24/02/2025
I’ve been thinking quite a bit on what will be our job as scientists in the AI era. I’m starting to think it will be all about finding new and meaningful questions.
www-bbc-co-uk.cdn.ampproject.org
AI cracks superbug problem in two days that took scientists years - BBC News
The lead researcher has told the BBC he was so astounded he assumed his computer had been hacked.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 21/02/2025
Today is Dr Paul Farmer's 3rd death anniversary A good day to remember the lessons he taught us, even as we face the chaos caused by the US administration's attacks on science, and global health www.forbes.com/sites/madhuk...
forbes.com
Paul Farmer’s Moral Clarity Offers Hope, Amidst Chaos And Darkness
On the 3rd anniversary of Dr Paul Farmer's death, several leaders reflect on his lessons for dealing with the ongoing crisis in global health and development
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Olivier Neyrolles @oneyrolles.bsky.social · 18/02/2025
Excited to have contributed to this fascinating study led by Rafael Prados Rosales! Uncovers how M. tuberculosis regulates extracellular vesicle production via VirR, shedding light on cell envelope remodeling & potential therapeutic targets! #MicroSky @elife.bsky.social doi.org/10.7554/eLif...
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Olivier Neyrolles @oneyrolles.bsky.social · 21/02/2025
Huge thanks to @marcopsilva.bsky.social, Thales Costa and all the students for the kind invite to speak at the @i3suporto.bsky.social Student symposium! 🌟 Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏 #i3Ssymposium
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Marco Silva @marcopsilva.bsky.social · 12/02/2025
First time at #EMBOtuberculosis presenting a part of my PhD work through a flash talk and poster presentation. Great to finally meet the TB community! Incredible experience in India, with amazing science, wonderful people, and delicious food! 🇮🇳
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Tiago Beites @tiagobeites.bsky.social · 12/02/2025
What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.
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Tiago Beites @tiagobeites.bsky.social · 31/01/2025
Esperar pelos resultados da FCT parece a emoção da Eurovisão. A quem vai dar a Estónia os 12 pontos?
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Tiago Beites @tiagobeites.bsky.social · 14/01/2025
Hi5 for everyone that submitted The grant today! What a journey!
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Olivier Neyrolles @oneyrolles.bsky.social · 19/12/2024
🎉 Thrilled to share the first paper by @saurabhchugh09.bsky.social, a talented Marie Skłodowska-Curie fellow in our lab! Discover how the exometabolome acts as a hidden driver of bacterial virulence and pathogenesis #MicroSky @cp-trendsmicrobiol.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
The exometabolome as a hidden driver of bacterial virulence and pathogenesis
The traditional view of metabolism as merely supplying energy and biosynthetic precursors is undergoing a paradigm shift. Metabolic dynamics not only …
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Tiago Beites @tiagobeites.bsky.social · 08/12/2024
A very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.
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Tiago Beites @tiagobeites.bsky.social · 24/11/2024
Ignorant drug development question. What’s missing on target-based drug development to make it truly useful? As opposed to the unbiased compound library screens that seem to be the gold standard. I may or may not be thinking on organizing a symposium to address this question.
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Tiago Beites @tiagobeites.bsky.social · 17/11/2024
Introducing my wonderful team at i3S - University of Porto. PhD student @marcopsilva.bsky.social and research fellow @alexjpinto.bsky.social
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Tiago Beites @tiagobeites.bsky.social · 12/11/2024
TRICK-TB is up and running! Collaboration with Robert Jansen with the support of CaixaResearch, laCaixaFoundation.
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Tiago Beites @tiagobeites.bsky.social · 03/02/2024
TB contributed to the extinction of Neanderthals? 😶 www.livescience.com/archaeology/...
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Tiago Beites @tiagobeites.bsky.social · 17/01/2024
Asking the void: are there good examples of compounds that targeted both host and pathogen enzymes (homologues) that were successfully modified/optimized to be selective for the pathogen’s enzyme?
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Tiago Beites @tiagobeites.bsky.social · 24/12/2023
2 house moves, change of country and continent, a new institution, new colleagues, 1 PhD student starting, 3 papers published and 2 grants written (and hopefully funded). Very challenging year but overall very positive and exciting. Happy holidays!
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Heran Darwin, PhD @heran.bsky.social · 14/12/2023
My first official post on bsky! @michaelglickman.bsky.social and I will be chairing the FIRST EVER #GRC on the Biology of Mycobacteria! Our goal is to focus on fundamental mycobacteriology for a broad audience. April 6-11, 2025 in Pomona, CA. Mark. Your. Calendars...
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Tiago Beites @tiagobeites.bsky.social · 14/12/2023
TB research friends, is there a good estimate of the (average) time from Mtb landing 🛬 in the alveolar space and being phagocytized? Minutes, hours, days, all of the above?
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Tiago Beites @tiagobeites.bsky.social · 30/11/2023
I'm happy to share the latest (but not the last!) story from my work @ Ehrt Schnappinger labs in its published form. Thank you to Sabine and Dirk for trusting me to coordinate this publication. Finally, thank you Yuanyuan for all your work and commitment. journals.asm.org/doi/10.1128/...
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