Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associate...

Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n....

Cover illustration Stress granules in iPSCs treated with arsenite (G3BP1 (green) / NUP107 (red) / Hoechst (nucleus)). Image credit: Saygin Bilican. The image refers to Bilican et al., “C9orf72 ALS-ca....

Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

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Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.

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C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.

A new DFG-funded research group investigates how proteostasis is regulated at the organismal level and its impact on aging and disease.

Nature Cell Biology - Toettcher, McNamara and colleagues use synthetic ‘signal-recording’ gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt...