iiinova — where your digital self keeps evolving

The American Society for Clinical Investigation @the-asci.org · 18/09/2026

ASCI member Chirag R. Parikh & team recently published in JCI Insight! In this peek Behind the Paper, authors Serena D. Souza and Wassim Obeid work on the new urine test that may help with earlier diagnosis for the rare kidney disease cystinosis in children 📎: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 09/09/2026

Mignot and Yanagisawa win the Lasker prize from from @laskerfdn.bsky.social for discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy: doi.org/10.1172/JCI2... In this Viewpoint, Clifford B. Saper places Mignot’s and Yanagisawa’s discoveries in a historical context.

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The American Society for Clinical Investigation @the-asci.org · 25/08/2026

Nominations are now open for ASCI’s 2027 Early-Career Awards (E-Gen & YPSA): buff.ly/Yv9Cmbb For early-career physician-scientists who have made notable achievements in their research, these awards encourage and inspire through broad participation in the ASCI physician-scientist community.

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The American Society for Clinical Investigation @the-asci.org · 11/08/2026

Meet our 2026 ASCI Postbaccalaureate (Postbac) Scholars. Congratulations Madelyn Blake and Luisa Morgan!

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The American Society for Clinical Investigation @the-asci.org · 07/08/2026

Meet the 2026-2027 ASCI PSSF Fellows! Our 5 Fellows were drawn from an exceedingly talented group of candidates nominated by their medical school dean.

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The American Society for Clinical Investigation @the-asci.org · 17/07/2026

📣Now open: ASCI nominations for active and international membership for 2027 may be submitted Deadline: September 10, 2026, 11:59 pm EST. buff.ly/wmMYast

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The American Society for Clinical Investigation @the-asci.org · 15/07/2026

📣📣Announcing 🎉🎉 Kevin N. Sheth, MD, receives the 2026 Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award. In this highlight, Dr. Kevin Navin Sheth offers some words for the aspiring physician scientist. For the full interview with Dr. Anna Greka: youtu.be/lcaHk_Y9VKM

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The American Society for Clinical Investigation @the-asci.org · 01/07/2026

📣📣Announcing 🎉🎉 Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award In this video highlight, Dr. Zikherman discusses important factors during her training time. The full interview with ASCI President-Elect Dr. Julie A. Bastarache: youtu.be/TwsTQ8O4XZw

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The American Society for Clinical Investigation @the-asci.org · 29/06/2026

ASCI member Rosas et al. report on its contribution to the profibrotic responses in activated lung fibroblasts & show macropinocytosis inhibition has potent anti-fibrotic effects in pulmonary fibrosis models: doi.org/10.1172/JCI1...

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The American Society for Clinical Investigation @the-asci.org · 27/06/2026

Endothelial cell glycogen synthase kinase 3β promotes lipotoxic endotheliopathy and liver inflammation in MASH: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 27/06/2026

Positioning GSK3β as a promising therapeutic target for MASH: doi.org/10.1172/jci.... Here, ASCI member Samar H. Ibrahim & team report lipotoxic GSK3β activation in LSECs drives mitochondrial dysfunction and fibroinflammation in MASH.

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The American Society for Clinical Investigation @the-asci.org · 23/06/2026

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis: doi.org/10.1172/JCI1...

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The American Society for Clinical Investigation @the-asci.org · 23/06/2026

NAD+ deficiency is associated with lung fibrosis Here, ASCI member Paul W. Noble & team boost a key NAD+ enzyme, NAMPT, to restore lung cell regeneration and reduce fibrosis, offering a potential treatment for idiopathic pulmonary fibrosis: doi.org/10.1172/JCI1...

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The American Society for Clinical Investigation @the-asci.org · 16/06/2026

A tribute to Eugene Braunwald (1929- 2026) by ASCI member Douglas E. Vaughan: doi.org/10.1172/JCI2... “A simple statement captures it best: cardiology before Braunwald and cardiology after Braunwald are not the same field.”

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The American Society for Clinical Investigation @the-asci.org · 15/06/2026

📣📣Announcing🎉🎉 Joseph C. Wu receives the 2026 ASCI/Stanley J. Korsmeyer Award Here are some highlights of Dr. Wu discussing his seminal contributions to the understanding and application of human iPSCs in cardiovascular disease from the interview with ASCI President Dr. Priscilla Y. Hsue.

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The American Society for Clinical Investigation @the-asci.org · 15/06/2026

Revealing a paradox behind the failure of vaccines that target virulence factors: doi.org/10.1172/jci.... ASCI member George Y. Liu & team find the efficacy of vaccines against S. aureus α toxin is reduced in aged mice due to senescence-related loss of toxin virulence function

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The American Society for Clinical Investigation @the-asci.org · 09/06/2026

ASCI member Albert R. La Spada & team show cell-free DNA isolated from blood of patients with amyotrophic lateral sclerosis has epigenetic methylation features that can accurately diagnose ALS and potentially predict disease progression: doi.org/10.1172/JCI1...

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The American Society for Clinical Investigation @the-asci.org · 09/06/2026

From improvised to intentional: Re-Imagining the physician-scientist career path: doi.org/10.1172/jci.... ASCI member Kyu Rhee & colleagues discuss the physician-scientist career at its crossroads, drawing from the 2025 ASCI/AAIM/BWF Workshop.

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The American Society for Clinical Investigation @the-asci.org · 08/06/2026

Tucatinib impairs proline biosynthesis and inhibits the proliferation of glioblastoma stem cells.

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The American Society for Clinical Investigation @the-asci.org · 08/06/2026

The interaction between FAM3C and SPIN1 proteins to prevent the lysosomal degradation of SPIN1 and promote the nuclear localization of SPIN1.

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The American Society for Clinical Investigation @the-asci.org · 04/06/2026

A strategy that destroys breast cancers in mice: doi.org/10.1172/jci.... ASCI member Eric J. Sorscher & team use ICIs in combination with an E. coli enzyme-based focal gene therapy to enhance tumor clearance and ablate tumor-supporting cells in the microenvironment.

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The American Society for Clinical Investigation @the-asci.org · 01/06/2026

📣📣Announcing Frederick Kofi Korley receives the 2026 ASCI/Louis W. Sullivan, MD, Award. Watch highlights from the interview with Stephen Y. Chan, and view the full conversation on YouTube: youtu.be/nsFj5tUKyEs

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The American Society for Clinical Investigation @the-asci.org · 01/06/2026

Metabolic reprogramming is critical to microglial activation in Huntington’s disease: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 01/06/2026

Metformin holds promise in Huntington’s disease: doi.org/10.1172/jci.... ASCI member Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in microglia, & controls microglial activation & inflammation in HD mice.

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The American Society for Clinical Investigation @the-asci.org · 29/05/2026

Liver-derived ceramides link metabolism to tissue wasting in cancer cachexia: doi.org/10.1172/JCI2... ASCI member Kerui Huang, Norbert Perrimon & Marcus D. Goncalves provide a Commentary on Morigny et al.: doi.org/10.1172/JCI1...

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The American Society for Clinical Investigation @the-asci.org · 28/05/2026

NET formation has been described in the TME doi.org/10.1172/JCI1... Here, ASCI member Lei Zheng & team find anti-CXCR2 antibody overcomes the NETosis-mediated resistance to MEK inhibition treatment in pancreatic cancer models by blocking infiltration of TANs to hypoxic/necrotic areas.

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The American Society for Clinical Investigation @the-asci.org · 27/05/2026

TLR2 signaling regulates T cell exclusion in pancreatic ductal adenocarcinoma

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The American Society for Clinical Investigation @the-asci.org · 27/05/2026

Towards improving immunotherapy outcomes in pancreatic cancer: doi.org/10.1172/jci.... ASCI member Gregory L. Beatty & team identify TLR2 as a driver of immune suppression in pancreatic cancer and show blocking TLR2 enables T cell entry and slows tumor growth in mice.

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The American Society for Clinical Investigation @the-asci.org · 26/05/2026

ASCI member Manish J. Butte @manishbutte.bsky.social & team report severe Valley fever occurring in males often features heightened allergy-like immunity, predisposed in some by genetic mutations, which suggests that targeted immune treatments can strengthen defenses: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 26/05/2026

ASCI member Manish J. Butte @manishbutte.bsky.social & team find that severe Valley fever is linked to a weakened immune response, pointing to treatments that could re-energize the body’s defenses: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 26/05/2026

Two Research articles in this issue explore immune phenotypes from individuals with coccidioidomycosis including those with severe, life-threatening disease: doi.org/10.1172/jci.... & doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 25/05/2026

What happens when GLP-1 weight-loss drugs are stopped and then restarted? ASCI member Thomas H. Leung & team asked this question in mice — cycling treatment made the drugs less effective over time and increased fat gain compared with continuous treatment: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 20/05/2026

Phase 2 trial of sodium phenylbutyrate & taurursodiol in Wolfram syndrome, a rare and progressive degenerative disease: doi.org/10.1172/JCI1... ASCI member Fumihiko Urano & team show treatment was associated with improved or stabilized pancreatic function, vision & overall symptom burden

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The American Society for Clinical Investigation @the-asci.org · 14/05/2026

Severity-dependent atrial remodeling and atrial fibrillation vulnerability in a clinically relevant aortic regurgitation mouse model: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 14/05/2026

~10% of individuals with cystic fibrosis are unresponsive to CFTR modulators. doi.org/10.1172/jci.... Here, ASCI member Garry R. Cutting & team report on gene editing for the correction of a common disease-causing variant in primary CF airway cells.

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The American Society for Clinical Investigation @the-asci.org · 04/05/2026

Merkel cell carcinoma (MCC) is an aggressive rare cancer of the skin. Here, ASCI member James A. DeCaprio & team find high tumor mutational burden and PIK3CA alterations are associated with worse MCC-specific survival: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 01/05/2026

Purpose, persistence, and progress: building the next generation of physician-scientists: doi.org/10.1172/JCI2... Through personal account, Cynthia Y. Tang celebrates 20 years of annual meetings @a-p-s-a.bsky.social and discusses the requirements for sustaining the workforce.

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The American Society for Clinical Investigation @the-asci.org · 01/05/2026

RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis: www.jci.org/articles/vie...

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The American Society for Clinical Investigation @the-asci.org · 01/05/2026

Metabolic syndrome and excessive alcohol consumption lead to liver fibrosis doi.org/10.1172/JCI1... ASCI member David A. Brenner & team @sbpdiscovery.bsky.social discover LARP6 as a master coordinator of hepatic stellate cell activation & fibrosis in human livers with MASH and MetALD

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The American Society for Clinical Investigation @the-asci.org · 28/04/2026

BMP7 treatment increased basal and stimulated cellular bioenergetics in human white preadipocytes (hWAs) after 7 or 30 days of BMP7 exposure. Oxygen consumption rate (OCR)

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The American Society for Clinical Investigation @the-asci.org · 28/04/2026

Behind the scenes with the Cypess lab: preparing samples and analyzing data.

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The American Society for Clinical Investigation @the-asci.org · 28/04/2026

Introducing a new therapeutic strategy to treat obesity-related metabolic disease👇 doi.org/10.1172/jci.... ASCI member Aaron M. Cypess & team treated human white adipocytes with BMP4 or BMP7, showing transition to distinct “tan” adipocytes with expanded energy expending capabilities.

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The American Society for Clinical Investigation @the-asci.org · 27/04/2026

Phage immunoprecipitation sequencing can map the antibody reactome doi.org/10.1172/jci.... ASCI member Aaron A.R. Tobian & team use it to evaluate Ab repertoires in HIV+ & HIV- kidney donors, reporting that Abs against adenovirus in donors were associated with increased rejection

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The American Society for Clinical Investigation @the-asci.org · 21/04/2026

Refuting the idea that coagulation contributes to persistent inflammation in treated HIV: doi.org/10.1172/jci.... ASCI member Ivona Pandrea & team report that adding FXa inhibitor to ART did not affect the pathogenesis of SIV infection or reduce hypercoagulability & inflammation

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The American Society for Clinical Investigation @the-asci.org · 17/04/2026

Spotlighting Kevin Navin Sheth (@yaleschoolofmed.bsky.social) for the ASCI / Scharschmidt~Crawford Distinguished Lectureship: From idea to impact: Building the future of brain diagnostics and care

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The American Society for Clinical Investigation @the-asci.org · 17/04/2026

Honoring Joseph C. Wu (@stanfordmedicine.bsky.social), recipient of the Korsmeyer Award—lecture underway!

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The American Society for Clinical Investigation @the-asci.org · 17/04/2026

Recognizing Consuelo H. Wilkins (@vumedicine.bsky.social) for the ASCI / Sullivan Award! Lecture underway: Advancing the rigor of Alzheimer’s disease research

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The American Society for Clinical Investigation @the-asci.org · 17/04/2026

Celebrating with Ann Chahroudi, Emory University School of Medicine, as she delivers the ASCI / Ropes Award Lecture: From HIV care to cure: Pediatric pathways to durable viral control

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