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tharaux-lenoir-lab.bsky.social

@tharaux-lenoir-lab.bsky.social
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Journal of Clinical Investigation @jci.org · 26/04/2026
ICYMI: Why are damaged muscles more likely to generate fatty tissue as we age? doi.org/10.1172/JCI1... Pei Wang & team find gasdermin E signaling unexpectedly promotes skeletal muscle repair by sustaining tissue-resident macrophage function and restraining maladaptive adipose tissue remodeling.
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Reposted by @tharaux-lenoir-lab.bsky.social
Nature Metabolism @natmetabolism.nature.com · 17/04/2026
dlvr.it
Mitochondrial iNOS blocks itaconate production by interacting with IRG1
Nature Metabolism, Published online: 10 April 2026; doi:10.1038/s42255-026-01493-0In this issue of Nature Metabolism, Diotallevi et al. propose a novel non-canonical function of inducible nitric oxide synthase (iNOS) as a regulator of immune-responsive gene 1 (IRG1, also known as ACOD1) enzymatic activity and the IRG1 protein interactome.
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Experimental Medicine @jem.org · 25/03/2026
Wetterwald, Köck et al. @petrovalab.bsky.social report the existence of an endothelial metabolic checkpoint where MYCT1 restricts activity of IFITM2/3 to prevent energy waste at the vascular barrier and enable fat storage. rupress.org/jem/article/... 🎥 See video summary: youtu.be/SGZ-5GiZvrI
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Experimental Medicine @jem.org · 25/03/2026
Iruela-Arispe highlights new work by @petrovalab.bsky.social (rupress.org/jem/article/...) showing that endothelial cells actively regulate energy storage in white adipose tissue through MYCT1–IFITM2/3-dependent control of endolysosomal trafficking & mTORC1 signaling. rupress.org/jem/article/...
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Reposted by @tharaux-lenoir-lab.bsky.social
Kidney International @kidneyint.bsky.social · 27/03/2026
Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes doi.org/10.1016/j.kint.2026.02.020 #MedSky #NephSky #OpenAccess #diabetes #diabeticnephropathy
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Clinical Investigation @jci.org · 16/03/2026
Patients with recurrent kidney stone disease stand to benefit from personalized diagnostics. Here, Ruxandra Bachmann-Gagescu & team perform deep biochemical phenotyping, revealing prognostic value of rare genetic variants in adult kidney stone disease: doi.org/10.1172/JCI1...
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 04/02/2026
ercsg2026.com A stimulating scientific event to present and discuss #kidneydisease #science4health #pathomechanisms #translationalresearch #emergingtherapies and more! The European kidney community will convene in Paris from April 9-12
ercsg2026.com
ERCSG2026 - European Renal Conference
Discover ERCSG2026 this April at Hôtel du Port, Nogent-sur-Marne. A leading renal conference combining science, networking, and inspiration.
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Reposted by @tharaux-lenoir-lab.bsky.social
JCI insight @insight.jci.org · 03/02/2026
Don’t overlook the kidney in SARS-CoV-2 pneumonia—even in the absence of overt acute kidney injury @olilen.bsky.social, Pierre-Louis Tharaux & team report on a strong association between kidney-derived proteins and IL-10 levels and mortality: doi.org/10.1172/jci....
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 01/02/2026
www.sciencedirect.com/science/arti... Podocyte targeted therapy: TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198
sciencedirect.com
TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198
In focal segmental glomerulosclerosis (FSGS), transient receptor potential cation channel, subfamily C, member 6 (TRPC6) overactivity might cause podo…
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 01/02/2026
www.myscience.org/en/news/2026...
myscience.org
COVID-19: discovery of renal and inflammatory markers predictive of disease severity
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Reposted by @tharaux-lenoir-lab.bsky.social
Inserm @inserm.fr · 29/01/2026
Des scientifiques de l'Inserm ont identifié des indicateurs biologiques permettant de prédire la mortalité à 3 mois des patients hospitalisés pour une pneumonie Covid-19 peu sévère. Lire le communiqué : presse.inserm.fr/covid-19-dec...
presse.inserm.fr
Covid-19 : découverte de marqueurs rénaux et inflammatoires prédictifs de la gravité de la maladie - Salle de presse de l'Inserm
Des chercheurs et des chercheuses de l’Inserm et de l’Université Paris Cité, dans le cadre de l’étude Corimuno-19 promue par l’AP-HP et financée par la Fondation pour la Recherche Médicale et l’ANRS M...
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 26/01/2026
@insight.jci.org the CORIMUNO-19 collaborative group releases a predictive score for COVID-19 and unravels the overlooked impact of subclinical acute kidney injury. @inserm.fr @ap-hp.bsky.social @inserm.fr @frm-officiel.bsky.social @anrs-mie.bsky.social 10.1172/jci.insight.198244
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Reposted by @tharaux-lenoir-lab.bsky.social
Kidney International @kidneyint.bsky.social · 06/10/2025
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. doi.org/10.1016/j.kint.2025.07.037 #OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social
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Reposted by @tharaux-lenoir-lab.bsky.social
Kidney International @kidneyint.bsky.social · 21/10/2025
Executive summary of the #KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV) doi.org/10.1016/j.kint.2025.04.003 #OpenAccess #MedSky #NephSky @kdigo.org
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Reposted by @tharaux-lenoir-lab.bsky.social
ASN Publications @asnpublications.bsky.social · 23/11/2025
Among hypertensive adults with ambulatory AKI, this #ASNCJASN study found plasma biomarkers reflecting impaired kidney tubule health measured at the time of ambulatory AKI are associated with subsequent non-recovery in kidney function. Read more: kidney.pub/CJASN0910
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Reposted by @tharaux-lenoir-lab.bsky.social
Marc Gozlan @marcgozlan.bsky.social · 14/11/2025
📚 Déjà 97 articles sur le blog 'Le #diabète dans tous ses états' ! Un contenu rigoureux et accessible. Physiopathologie, traitements, complications, innovations… Une ressource unique pour comprendre toutes les facettes de cette maladie complexe www.le-diabete-dans-tous-ses-etats.precidiab.org
le-diabete-dans-tous-ses-etats.precidiab.org
Le Diabète dans tous ses états
Un blog, comme aucun autre, pour découvrir et tout comprendre des mille et une facettes du diabète et de l’obésité.
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Reposted by @tharaux-lenoir-lab.bsky.social
Marc Gozlan @marcgozlan.bsky.social · 18/11/2025
Syndrome d’auto-brasserie : être ivre sans boire une goutte d’alcool Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang. www.lemonde.fr/blog/realite... [Rediff]
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Clinical Investigation @jci.org · 11/11/2025
Video Abstract: Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation: youtu.be/oSB3CP5UDPE
youtu.be
Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation
In this episode, Marie Jeansson explains how the paper's findings suggest that TIE2 activation via angiopoietin-2–binding and TIE2-activating antibody warrants investigation as a therapy in human…
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Reposted by @tharaux-lenoir-lab.bsky.social
Le Monde @lemonde.fr · 11/10/2025
Cancer : la France doit savoir pourquoi elle est surexposée
lemonde.fr
Cancer : la France doit savoir pourquoi elle est surexposée
L’étude du « Lancet », qui a placé la France en tête des pays les plus touchés, doit servir de signal d’alarme. Qu’un pays développé ignore l’ensemble des causes d’une incidence singulière du cancer n’est pas acceptable.
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 11/10/2025
Mineralocorticoid Receptor #MR inhibition in parietal epithelial cells #PEC prevents #FSGS and #crescenticGN. Furthermore, we didn’t find 11βHSD in PECs, suggesting that standard of care could stimulate MR, which is not optimal. @isgd.bsky.social doi.org/10.1016/j.ki...
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Clinical Investigation @jci.org · 08/10/2025
Perturbation of the circadian clock in chronic diseases involving organ fibrosis This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 09/10/2025
Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of #diabetes and #metabolic syndrome?
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 26/09/2025
Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!
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tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 26/09/2025
Inhibiting MR protects against glomerular damage by preventing the activation of parietal epithelial cells. A novel mechanism that should impact medical practice. www.sciencedirect.com/science/arti... @parcc-inserm.bsky.social @olilen.bsky.social @upcite.bsky.social @inserm.fr
sciencedirect.com
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
Focal segmental glomerulosclerosis (FSGS) is a common histological lesion in adults worldwide. It results from initial podocyte injury, followed by a …
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Reposted by @tharaux-lenoir-lab.bsky.social
Nature @nature.com · 25/09/2025
Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation go.nature.com/3KBRg2W
go.nature.com
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Clinical Investigation @jci.org · 20/09/2025
Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Experimental Medicine @jem.org · 03/09/2025
Hoover, Hacohen, Davidson @northwellhealth.bsky.social et al. analyze the intrarenal myeloid compartment in four #lupus #nephritis mouse models and 155 humans using single-cell profiling, spatial transcriptomics, and functional studies. rupress.org/jem/article/...
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Experimental Medicine @jem.org · 04/09/2025
Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...
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Reposted by @tharaux-lenoir-lab.bsky.social
Kidney International @kidneyint.bsky.social · 19/08/2025
Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study Commentary by S Jesudason & G Piccoli doi.org/10.1016/j.kint.2025.05.011 Original article: doi.org/10.1016/j.kint.2025.04.017 #MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph
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Reposted by @tharaux-lenoir-lab.bsky.social
Kidney International @kidneyint.bsky.social · 02/09/2025
Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline doi.org/10.1016/j.kint.2025.07.024 #NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social
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Kidney International @kidneyint.bsky.social · 03/09/2025
Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions doi.org/10.1016/j.kint.2025.07.022 #NephSky #MedSky #AKI #acutekidneyinjury
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Reposted by @tharaux-lenoir-lab.bsky.social
Journal of Clinical Investigation @jci.org · 26/07/2025
ICYMI: Chemotaxis as a driver in immune privilege. O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege. buff.ly/Mwn8t1c
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Reposted by @tharaux-lenoir-lab.bsky.social
Nature Reviews Nephrology @natrevneph.nature.com · 27/07/2025
ICYMI:
nature.com
The link between dementia and kidney disease demands changes in patient care
Nature Reviews Nephrology, Published online: 21 July 2025; doi:10.1038/s41581-025-00984-9The risk of cognitive impairment and dementia in people with chronic kidney disease is under-recognized. Better awareness and early intervention are crucial to improving patient outcomes.
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Extreme Temperatures Around the World @extremetemps.bsky.social · 05/07/2025
‼️EXTRAORDINARY WORLD RECORD Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m ! WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit) Also crazy 46.1C Bunji 🇵🇰1469m asl History is rewritten again
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Reposted by @tharaux-lenoir-lab.bsky.social
Eric Topol @erictopol.bsky.social · 05/07/2025
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports. erictopol.substack.com/p/new-anti-a...
Organ clocks for post-menopausal women taking estrogen or not taking estrogen
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Extreme Temperatures Around the World @extremetemps.bsky.social · 05/07/2025
Hot day on the French Riviera: With 37.4C Sete broke its record of July highest temperature on record.
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Extreme Temperatures Around the World @extremetemps.bsky.social · 05/07/2025
East Asia: The hell is coming. Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C. Records will be hundreds (at best)
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Yale School of Public Health @yalesph.bsky.social · 21/06/2025
A highly transmissible new COVID-19 variant is spreading in the U.S. “Those in high-risk groups should consider getting the vaccine now if they haven’t been vaccinated in the last six months," Prof. Albert Ko told TODAY. www.today.com/health...
today.com
New COVID Variant NB.1.8.1 'Nimbus' Now Driving 37% of Cases in US: Know These Symptoms
A highly transmissible new COVID-19 variant called NB.1.8.1, aka "Nimbus," is spreading in the United States, CDC data show. What to know about symptoms and vaccines.
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Journal of Clinical Investigation @jci.org · 21/06/2025
A proof-of-concept study for determining the functional impact of variants of uncertain significance (VUS)! Muthiah Bose et al. used CRISPR-Select as a tool in the classification of rare VUS in the PALB2-binding domain of BRCA2: buff.ly/oFc574N
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Journal of Clinical Investigation @jci.org · 15/06/2025
ICYMI: A smooth operator for blood pressure! Katherine Gallagher & team show the histone demethylase JMJD3 in vascular smooth muscle cells regulates endothelin receptor expression and blood pressure: buff.ly/K8b0CnB
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Extreme Temperatures Around the World @extremetemps.bsky.social · 15/06/2025
EXTRAORDINARY- MOST EXTREME HEAT WAVE IN WORLD CLIMATIC HISTORY 52.6 in Kuwait,widespread 49/50C in a dozen countries. 44C at 45 latitude in Kazakhstan with night minimums up to 29C Next days Dozens of thousands of records from Morocco to Japan broken locally with 5/6C margins
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International Society of Glomerular Disease @isgd.bsky.social · 12/06/2025
🚨 LATE-BREAKING SESSION ALERT 🚨 #PodocyteConference 🐙 Pathology-oriented multiplex integrative mapping - Victor Puelles introduces the PathoPlex! 🔥 Can we relate outcomes with disease-specific tissue mapping? 🧐 tobias-b-huber.bsky.social
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International Society of Glomerular Disease @isgd.bsky.social · 13/06/2025
🌟 EMERGING CAREER HIGHLIGHTS 🌟 #PodocyteConference 🐙 Fantastic talk by Charlotte Boys on the molecular heterogeneity of PEC proliferation in IgAN and FSGS - future secrets for crescents? 🌙 tobias-b-huber.bsky.social
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International Society of Glomerular Disease @isgd.bsky.social · 13/06/2025
Prof. dannygale.bsky.social‬ enlightens how studying large cohorts, such as the RaDaR Registry, allows for deeper understanding and gap closing in rare diseases 🔑 #PodocyteConference 🐙 ukkidney.org‬ tobias-b-huber.bsky.social
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International Society of Glomerular Disease @isgd.bsky.social · 13/06/2025
A look into the future by Prof. Moin Saleem 🧐 at the #PodocyteConference 🐙 Walking towards gene therapy in Glomerular Diseases 🧬🤯 kidneyresearchuk.org‬ tobias-b-huber.bsky.social
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International Society of Glomerular Disease @isgd.bsky.social · 13/06/2025
Brilliant talk by Prof. Ulf Panzer at the #PodocyteConference 🐙 From immune-profiling to precise treatment 🎯 and a new hypothesis involving Granzyme K in ANCA-GN 🌟 tobias-b-huber.bsky.social
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International Society of Glomerular Disease @isgd.bsky.social · 13/06/2025
Excellent lecture and work on the central role of PECs in crescent formation 🌙 by Prof. Pierre-Louis Tharaux at the #PodocyteConference 🐙 tobias-b-huber.bsky.social
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International Society of Glomerular Disease @isgd.bsky.social · 13/06/2025
Exciting news! 🌟 The ISGD Centers of Excellence in Glomerular Disease (COE-GD) criteria have been finalized after 2+ years of meticulous work. Read our full press release here and learn about our commitment to advance GD care, research, and advocacy! 👉 bit.ly/COE-GD #ISGD #GlomerularDisease #COEGD
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Eric Topol @erictopol.bsky.social · 13/04/2025
p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease. erictopol.substack.com/p/the-breakt... Here's the rundown on it. Free, open-access.
erictopol.substack.com
The Breakthrough Blood Test for Alzheimer's Disease
The p-Tau217 Biomarker for Prediction and Prevention
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Eric Topol @erictopol.bsky.social · 08/04/2025
The real problem about science isn't about loss of trust. It's about not having a voice, a counter. @nature.com www.nature.com/articles/d41... Whai if the 300,000 scientists supported by NIH stood up? Or even half of them. Instead of <1%
nature.com
Science’s big problem is a loss of influence, not a loss of trust
Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.
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