Reposted by Nicholas Tatonetti, PhD
Somatic Y chromosome loss is mapped at single-gene resolution across cancers and is shown to follow region-specific patterns associated with transcriptional dysregulation and poorer clinical outcomes. @tatonetti.bsky.social @cedarssinaicancer.bsky.social
www.nature.com/articles/s42003-026-10875-9
nature.com
Recurrent deletions and regulatory disruption of the Y chromosome in cancer - Communications Biology
Using high-coverage whole-genome sequencing and transcriptomics of male cancer cell lines, the authors map the landscape of somatic Y chromosome loss at single-gene resolution. Y chromosome erosion is...