Interesting biology, a possible “Goldilocks” effect, and a lot we still do not know

Could hearing loss be a second hit to a vulnerable brain?

How much alcohol is too much with APOE4?

Toward precision inflammation trials in Alzheimer disease

A reading into brain games, cognitive stimulation, and dementia prevention

What the Evidence Means for Lean APOE4 Carriers

Tau PET tracks Alzheimer’s disease better than amyloid PET, but tracking disease is not the same as proving what will rescue the brain.

APOE2 may protect the aging brain, but it is not a simple genetic upgrade.

The Protein Longevity Paradox

Why movement may matter most before symptoms begin — and what to do now.

What a Major New Study Says About an Alzheimer’s Blood Test, and What It Doesn’t

Progress, Missed Opportunities and Why Lifestyle Trials for Alzheimer’s Are So Hard to Get Right

Ambitious studies have been examining the protective effects of diet, exercise and socializing — with surprising results.

A placebo-controlled trial put fish oil supplements to the test. Over two years, the supplements failed to slow cognitive decline in adults.

Before You Believe the Headline

Alzheimer’s prevention may depend on how the brain metabolizes omega-3s.

Insights from tissue specific immune aging biomarkers

The MINDFuL trial: A Case Study in the Missing Inflammation Biomarker

Why Alzheimer’s science demands both hope and caution

How Your Brain Cleans Itself -- and What It Means for Alzheimer's

What the evidence supports about lecanemab and donanemab — and what it does not.

And why association is not causation

A drug designed to supercharge the brain's immune cells just failed its biggest clinical test; but all is not lost.

How mental activity affects the risk of dementia

A fresh Perspective on vascular inflammation in AD

No single diet, supplement, or habit made her 117.

What if Alzheimer's isn't just about the buildup of toxic proteins — but about the immune cells that were supposed to clean them up, and why they eventually stop doing their job?

Observational studies can drive you nuts!

SPARK (Supporting Progress in Alzheimer's Research and Knowledge) is a program that connects participants with research opportunities and helps advance discoveries in Alzheimer's disease and dementia. Your de-identified survey responses also contribute to research, ensuring your privacy while enabling researchers to better understand the factors that influence brain health.

One of the most debated hypotheses in modern medicine

Understanding the benefits, risks, and unanswered questions surrounding hormone therapy and cognitive aging.

Why the best case for statins in APOE4 is vascular, not “Alzheimer’s treatment”

New human data on an inflammatory enzyme linked to cognitive impairment in Alzheimer's disease

A 70-year-old man came for a second opinion on optimizing brain health.

I recently saw an 85-year-old man in clinic because his memory has been declining.

A 55-year-old woman sits across from me in clinic.

The new dietary guidelines arrive at a moment when nutrition science is finally catching up with biology.

As we enter a new year, I want to wish you a healthy 2026 and share a bit of the story behind our most recent paper (published online today).

Merry Christmas, everyone.

I was at Costco recently, walking through the supplement aisle, when I noticed how much space is now devoted to krill oil and other omega-3 products.

This story starts with a simple but powerful idea: the brain’s immune cells can burn out. In Alzheimer’s disease, the main cleanup crew—microglia—spend years immersed in low-grade inflammation, consta...

For almost a decade, scientists have been intrigued by the possibility that Alzheimer’s disease might be, at least in part, a disorder of brain energy failure. The brain runs on glucose, and many earl...

In the PISCES trial, 1,228 adults on long-term hemodialysis in Canada and Australia were randomized to receive either 4 grams per day of fish oil (1.6 g EPA + 0.8 g DHA) or a corn-oil placebo for 3.5 ...

Alzheimer’s disease has historically been viewed through the lens of amyloid plaques and tau tangles, but accumulating evidence shows that these features alone cannot fully explain why some individual...

Experts say White House presented ‘association as causation’ and based conclusions on ‘poor quality studies’

Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease-Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single....

UC Irvine study finds sex differences may impact treatment approaches

UC Irvine study finds sex differences may impact treatment approaches