Oncogenic KRAS causes replication stress that threatens genome stability during cancer development. Here, the authors show that ATR-regulated PrimPol switches between fork slowing and repriming modes ...

Using single-molecule imaging and manipulation, the authors show linker histone H1 preferentially forms phase-separated droplets with single-stranded nucleic acids over double-stranded DNA and nucleos...

Song et al. report that ATM maintains replication fork speed by counteracting chromatin-bound cGAS-induced fork slowing. They show that ATM and ATR phosphorylate MRE11 to release cGAS from chromatin i...

Replication fork stalling or slowdown is a hallmark of replication stress and can lead to DNA damage-induced fork collapse and genetic instability. Stalled replication forks must be stabilized to enab...

Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous cells through distinct mechanisms, partly counteracting the mismatch repair factor MLH1. In cancer cells, B...

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

Divergent satellite DNA shapes influence architectural protein binding and chromatin organization in two mouse species so that the satellites can be packaged and centromere function maintained, mitiga...