A new paper from B-Lab is out in Nature Communications!
We discovered that ATR-regulated PrimPol switches between fork slowing and repriming to help cells tolerate oncogenic KRAS-induced replication stress, promoting survival while limiting error-prone DNA synthesis.
www.nature.com/articles/s41...
nature.com
PrimPol toggled by ATR modulates fork slowing and repriming under oncogenic KRAS-induced replication stress - Nature Communications
Oncogenic KRAS causes replication stress that threatens genome stability during cancer development. Here, the authors show that ATR-regulated PrimPol switches between fork slowing and repriming modes ...
