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Swaminathan Lab @swaminathanlab.bsky.social · 23/02/2026

Fantastic news and congratulations Carlos!!

Reposted by Swaminathan Lab

Seema Grewal @seemagrewal.bsky.social · 09/01/2026

We’re hiring! @jcellsci.bsky.social is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves #cellbiology and wants to stay connected with the field. A great chance to work for an organisation that believes in helping the community! Details below👇

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Swaminathan Lab @swaminathanlab.bsky.social · 27/11/2025

Congratulations and beautiful website.

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Swaminathan Lab @swaminathanlab.bsky.social · 14/10/2025

🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel tinyurl.com/stnczkc6

advanced.onlinelibrary.wiley.com

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion...

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Swaminathan Lab @swaminathanlab.bsky.social · 23/07/2025

Amazing work Abby! Congrats to all authors

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Reposted by Swaminathan Lab

Matthew Cobb @matthewcobb.bsky.social · 26/06/2025

Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...

youtube.com

The Most Beautiful Experiment: Meselson and Stahl

YouTube video by Science Communication Lab

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Swaminathan Lab @swaminathanlab.bsky.social · 12/05/2025

The feeling when you get back to the lab after a week at a gordon conference - totally inspired and energised after hearing incredible science and meeting amazing people. Thank you @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for GRC Fibronectin, Integrins and related molecules.

media.tenor.com

Amazed Inspired GIF

Alt: Amazed Inspired GIF

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Swaminathan Lab @swaminathanlab.bsky.social · 28/04/2025

as usual beautiful data. big congrats!

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Swaminathan Lab @swaminathanlab.bsky.social · 24/04/2025

Fantastic surprise to have Reinhard Fässler visit Lund to talk about kindlins, integrins and mitosis.

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Reposted by Swaminathan Lab

Kristian Pietras lab @kpietraslab.bsky.social · 23/04/2025

Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺. Apply now👇 tinyurl.com/4mby45hf

tinyurl.com

Postdoc in Experimental Oncology - Lund (Stad), Skåne (SE) job with Lund University | 12838990

Lunds universitet, 009999 LUNDS UNIVERSITET, 310000 MED Lund University was founded in 1666 and is repeatedly ranked among the world’s top universi...

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Swaminathan Lab @swaminathanlab.bsky.social · 20/03/2025

Holy wow-- this is amazing!! Congratulations!

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Swaminathan Lab @swaminathanlab.bsky.social · 17/03/2025

Seems like a good time to share and appreciate this incredible window to future cancer treatments and the opportunities ahead (and also appreciate its journey from test tubes to bacteria to cell culture to animal models to covid vaccine and now to this-) www.nature.com/articles/s41...

nature.com

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature

In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...

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Reposted by Swaminathan Lab

Katie Langin @klangin.bsky.social · 14/02/2025

Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.

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Swaminathan Lab @swaminathanlab.bsky.social · 10/02/2025

Big first for our lab on Friday as Wesley became its first PhD graduate. Congrats Wesley and a big thanks to an amazing committee including @bengoult.bsky.social (opponent), @sciezgin.bsky.social , Gunilla Westergren-Thorsson, Catharina Hagerling and Daniel Engelbertsen.

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Swaminathan Lab @swaminathanlab.bsky.social · 01/02/2025

🚨🚨🚨Come and join us at the Wallenberg Center for Molecular Medicine- tenure track positions in broad areas of 1)basic research and 2)advanced therapy in regenerative medicine. 🚨Deadline Feb 10th. DM me if you have any questions lu.varbi.com/en/what:job/... lu.varbi.com/en/what:job/...

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Swaminathan Lab @swaminathanlab.bsky.social · 22/01/2025

This work has led us now into a whole range of new projects and collaborations that we are very excited about. This project was a collaboration with the groups of Adam Simonsen at SDU, Cathy Merry and Amanda Wright at Nottingham and Pontus Nordenfelt

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Swaminathan Lab @swaminathanlab.bsky.social · 22/01/2025

This work was inspired and stands on the shoulder of amazing work from several labs that have been developing alginate based hydrogel system and/or have been working on ECM stiffness-mechanotransduction pathways in epithelial structures for decades

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Swaminathan Lab @swaminathanlab.bsky.social · 22/01/2025

Mechanistically, using antibodies, inhibitors etc, Kabilan found that this process of in-situ stiffening induced ECM remodelling and invasion of normal mammary acini was driven by beta1 integrin-FAK-Piezo1 pathway with Piezo1 specifically being downstream of integrin activation and signalling.

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Swaminathan Lab @swaminathanlab.bsky.social · 22/01/2025

Kabilan then followed the process of in-situ stiffening induced changes in acini morphology and ECM properties over time and found interesting and "dynamic" changes in relative ECM enrichment which coincided with different stages of growth and the onset of invasion

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Swaminathan Lab @swaminathanlab.bsky.social · 22/01/2025

Interestingly, he found several differences in basement membrane and ECM(Fibronectin) enrichment and organisation between acini embedded in in-situ stiffened gels compared to acini formed from single MCF10A cells embedded in stiff gels from Day 1 (see below)

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Swaminathan Lab @swaminathanlab.bsky.social · 22/01/2025

Here Kabilan first embedded single MCF10A cells in a soft interpenetrating network hydrogel system and allowed it to form a normal mammary acini with its own native ECM environment. He then in-situ stiffened these gels thus mimicking tumour growth and invasion on normal 3D structures-

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Reposted by Swaminathan Lab

Megan Chastney @mchastney.bsky.social · 20/01/2025

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

grc.org

2025 Fibronectin, Integrins and Related Molecules (GRS) Seminar GRC

The 2025 Gordon Research Seminar on Fibronectin, Integrins and Related Molecules (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

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Reposted by Swaminathan Lab

Johanna Englund @johannaienglund.bsky.social · 20/01/2025

Are you working on #ECM or mechanobiology in the mammary gland or in breast cancer? Together with Jason Northey we are guest editing a collection on the topic for the Journal of Mammary gland biology and Neoplasia. Submission of articles is now open! link.springer.com/collections/...

Mammary tumor tissue stained with collagen (green) and nuclei (red)

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Swaminathan Lab @swaminathanlab.bsky.social · 20/01/2025

This is a scientific life changing experience-

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Swaminathan Lab @swaminathanlab.bsky.social · 20/01/2025

this is beautiful. Fantastic work.--

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Reposted by Swaminathan Lab

Jennifer Waters @jencwaters.bsky.social · 13/01/2025

Hey PIs, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available. meetings.cshl.edu/coursesinten...

meetings.cshl.edu

Courses Intent to Apply Form

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

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Reposted by Swaminathan Lab

Martin Humphries @martinhumphries.bsky.social · 09/01/2025

Sakthivel K, et al. {beta}1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium. bioRxiv posted 8 January 2025 doi:10.1101/2025.01.07.631639. www.biorxiv.org/content/10.1...

biorxiv.org

β1 Integrin–FAK–Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium

Stiffening of tissue is a hallmark of cancer progression, driving invasive phenotypes through complex interactions between cells and their extracellular matrix (ECM). However, the mechanisms linking m...

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Reposted by Swaminathan Lab

Victor Tatarskiy @greenrat.bsky.social · 26/12/2024

In all seriousness,use CiteAb and Antibodypedia, look for KO/KD validated antibodies, best - recombinant, second best - monoclonal, and if possible do your own KO/KD controls, or induction by ligand/small molecule,if not - compare hyperexpressing with low expressing cells (from depmap/protein atlas)

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Swaminathan Lab @swaminathanlab.bsky.social · 27/11/2024

I would win this if falling asleep in the room is an allowed strategy.

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Reposted by Swaminathan Lab

Sylvain Gabriele @sgabriele.bsky.social · 21/11/2024

Pre-announcing the 10th Biennial European CellMech conference organized in Leuven 🇧🇪 from September 30th to October 3rd, 2025. cellmech2025.org Save the date !

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Swaminathan Lab @swaminathanlab.bsky.social · 25/11/2024

The GRC scam emails are getting quite good, huh?

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Swaminathan Lab @swaminathanlab.bsky.social · 14/11/2024

There is lots more to tell about the university, the centre, the people and the country. Contact me if you have any questions.

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Swaminathan Lab @swaminathanlab.bsky.social · 14/11/2024

The town boasts 2 giant science infrastructures including MAX IV which is the world's first 4th generation synchrotron light source facility and soon to open, the European Spallation Source ERIC (ESS) en.wikipedia.org/wiki/Europea...

en.wikipedia.org

European Spallation Source - Wikipedia

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Swaminathan Lab @swaminathanlab.bsky.social · 14/11/2024

Lund is a fantastic college town 10-15 mins from Malmö and 30-40 minutes from Copenhagen airport. Its home to several biomedical and tech companies, excellent schools, a fantastic university and just incredible diverse people en.wikipedia.org/wiki/Lund

en.wikipedia.org

Lund - Wikipedia

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Swaminathan Lab @swaminathanlab.bsky.social · 14/11/2024

Wallenberg centre for Molecular medicine(WCMM) is an initiative funded by the Knut and Alice Wallenberg Foundation. The link to WCMM Lund is: www.wcmm.lu.se/wallenberg-c...

wcmm.lu.se

Wallenberg Center for Molecular Medicine

Lund University.

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Swaminathan Lab @swaminathanlab.bsky.social · 14/11/2024

Seems like a good time to post this: Our centre is recruiting a tenure-track PI with focus on basic research into regenerative medicine and disease mechanisms. Excellent start-up package, colleagues & infrastructure in a fantastic college town.Other useful links below lu.varbi.com/en/what:job/...

lu.varbi.com

Associate Senior Lecturer (WCMM Fellow) in Molecular Medicine with a focus on basic research into regenerative medicine and disease mechanisms

In this call for proposals ( Wallenberg Molecular Medicine Fellow ), we are looking for prominent researchers with international research experience. The position is located at the Faculty of Medicine

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Guillaume Jacquemet @guijacquemet.bsky.social · 11/11/2024

I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added go.bsky.app/5Gzo7oZ

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