A threshold-based phospho-switch of DVL mediates Wnt signaling and rationalizes DVL’s domain architecture.

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Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on microtubules.

The conserved atypical cadherin fat (ft) controls cellular processes such as growth, planar cell polarity, and mitochondrial function, in organisms ranging from fruit flies to mammals. Working at the ...

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

Morphogenesis involves interactions between biochemical and mechanical cues. Trinidad et al. show that during Drosophila pupal wing morphogenesis, Fat-Dachsous planar polarity competes with tissue tension to control oriented cell behaviors. Moreover, junctional tension stabilizes Fat-Dachsous, supporting the existence of biomechanical feedback.

Convergent extension (CE) is an evolutionarily conserved developmental process that elongates tissues and organs via collective cell movements known a…

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In developing epithelia, cells become planar polarised with asymmetric localisation of the core plan

Cell contacts in epithelia are remodeled to regulate paracellular permeability and to control passag