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Kevin Stachelek

@stchlk.bsky.social
277 followers 1.3K following 24 posts

Everything matters. Time will tell who was right and who was wrong.

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Reposted by Kevin Stachelek
Chise @sailorrooscout.bsky.social · 11/09/2026
GOOD NEWS! A personalized mRNA vaccine has SUCCEEDED in keeping melanoma, a deadly skin cancer, from returning. Phase III trial results in MORE THAN 1,100 patients shows the vaccine SIGNIFICANTLY extended the time patients lived without their melanoma returning AND reduced the risk of metastasis.
statnews.com
Moderna and Merck say mRNA cancer vaccine succeeded in late-stage melanoma trial
A personalized mRNA cancer vaccine succeeded in a late-stage melanoma study, results that could herald a new, powerful approach in oncology.
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Simon P. Couch @simonpcouch.com · 09/09/2026
RUN ML MODELS DIRECTLY IN YOUR DATABASE
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Joshua Shapiro @josh.shapiro.foo · 30/06/2026
Hey look, our paper about the Single-cell Pediatric Cancer Atlas that we at @cancerdatalab.bsky.social have been working on for a while is out! www.cell.com/cell-genomic... It's a pretty good resource, if I do say so myself, and we are expanding: if you have data you want to share, get in touch!
cell.com
The Single-Cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors
Hawkins et al. introduce the Single-Cell Pediatric Cancer Atlas: a uniformly processed collection of sc/snRNA-seq data from pediatric cancer samples and models. 700 samples from 55 pediatric cancer ty...
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Kevin Stachelek @stchlk.bsky.social · 10/06/2026
Dan Simmons
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Saloni @scientificdiscovery.dev · 04/06/2026
New short blogpost! I wrote a round up of cancer research news from ASCO2026: - Daraxonrasib, the breakthrough pancreatic cancer drug - Big 7-year results of lorlatinib for ALK+ lung cancers – Talazoparib, a prostate cancer drug that cut the risk of progression by half and much more. Read here:
abundanceandgrowth.org
Cancer breakthroughs at ASCO
A What we're reading spotlight
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Alicia Oshlack @aliciao.bsky.social · 27/05/2026
New paper from the lab! Spoiler: data driven methods performed better for normalisation than spike in CUT&RUN (again). Congratulations especially to Krutika Ambani for most of the work here now embarking on a PhD.
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🇵🇸Martin “Doomsday” Pfeiffer🖖🏳️‍🌈 @nuclearanthro.bsky.social · 19/05/2026
I have written a post about the State of Los Alamos; its inability to substantially accelerate or add new missions; and why trying to do so is a bad idea. Also: don't touch things in Plutonium Facility-4 & I'd stay out of the Basement & away from its mysteries. #PhDLife Free & accessible to all.
patreon.com
Los Alamos: Filthy, Strained, Exemplary | Martin Pfeiffer
Los Alamos: Filthy, Strained, Exemplary by Martin Pfeiffer on Patreon. Join Martin Pfeiffer's community for exclusive content and updates.
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Sheryl Weikal says Prosecute ICE @leftistlawyer.com · 10/05/2026
THREAD. There's been a lot of attention paid to the new 2026 United States Counterterrorism Strategy released by the Trump administration released this week, and understandably so. I've linked it here so you can review it for yourself.
whitehouse.gov
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Sammy Roth @sammyroth.bsky.social · 08/05/2026
Colorado just became the third state to legalize balcony solar. Virginia will probably be next: www.cpr.org/2026/05/07/c... via @sambrasch.bsky.social
cpr.org
Colorado approves balcony solar, but approved units aren’t widely available yet
Gov. Polis signed a bill into law on Thursday making Colorado the third state to clear a path for plug-in solar kits.
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Ben Collins @bencollins.bsky.social · 20/04/2026
With the help of the Sandy Hook families, The Onion has reached a long-awaited deal to take over InfoWars. We've enlisted the help of @timheidecker.bsky.social, who will be InfoWars' Creative Director. Please stand by for more.
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Mariko Bennett @nachoriko.bsky.social · 24/03/2026
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
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Will Macnair @willmacnair.bsky.social · 19/03/2026
I've only skimmed the paper but this looks pretty impressive!
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Mayor Zohran Kwame Mamdani @mayor.nyc.gov · 13/03/2026
Let there be as much outrage from politicians in Washington when kids go hungry as there is when I break bread with New Yorkers.
Senator Tuberville on x writing a response to the @endwokeness account 

Original tweet from @EndWokeness - “less than 25 years apart”
Image 1 - the twin towers as they are hit by a the planes on 9/11/2001
Image 2 - Mayor Mamdani sitting on a prayer rug while hosting an Iftar  at city hall

Quote tweet from Senator Tuberville - “the enemy is inside the gates.”
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Emil Hvitfeldt @emilhvitfeldt.bsky.social · 13/03/2026
I'm over the moon excited to the release of 0.5.0 of orbital 🛰️ This release adds full support for boosted tree, faster creation of orbital objects, optimization of execution! We can finally reliably predict with a xgboost model from a database! tidyverse.org/blog/2026/03... #rstats #tidymodels
tidyverse.org
orbital 0.5.0
orbital 0.5.0 is on CRAN! More models and faster execution.
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Kevin Stachelek @stchlk.bsky.social · 28/02/2026
I didn’t know any of these albums before and I’ve loved every one so far!
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Dan Warren @danlwarren.bsky.social · 13/02/2026
I cannot overstate how good this account is
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The Verge @theverge.com · 27/01/2026
"I didn’t realize, in the hours before his name was released to the public, that the man millions of people had seen lying facedown on the pavement from multiple angles of eyewitness video was my childhood best friend." Read more from @kristenradtke.bsky.social: www.theverge.com/policy/86856...
Verge headline: I grew up with Alex Pretti
by Kristen Radtke

Photo: An old picture of a boy and a girl at a birthday party
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Jeff Mold @jeffmold.bsky.social · 22/01/2026
I have a serious question for the bioinformatics community - it is now very trendy to assign genes to modules or groups and then annotate those groups using various strategies. When I read the methods for papers it is unclear to me how one comes up with the strategy they use - see below:
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Childhood Cancer Data Lab @cancerdatalab.bsky.social · 20/01/2026
Exciting news from the #SingleCell #PediatricCancer Atlas (ScPCA) Portal! We’ve rolled out a suite of new features to help you extract deeper insights from your ScPCA datasets. Read our blog to see how these updates can help you save time and work more efficiently.
ccdatalab.org
New Feature Release: Cell Type Annotations, CNV Inference, Custom Downloads, and More on the ScPCA Portal
Exciting news from the Single-cell Pediatric Cancer Atlas (ScPCA) Portal! All datasets on the portal have been updated to include several new features that enhance data quality and usability. Here’s a...
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Kevin Stachelek @stchlk.bsky.social · 18/01/2026
Watched for the first time last night! Was very distracted by the beautiful suits
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phylan @phylan.website · 13/01/2026
STAY VIGILANT. STAY APPRISED OF THE BOZO READINESS CONDITION bozo.watch
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East Bay Booksellers @ebbooksellers.bsky.social · 08/01/2026
Please see the award-winning poem by Renee Nicole Good, who was murdered by the US government today in Minneapolis. poets.org/2020-on-lear...
poets.org
2020 Academy of American Poets Prize
On Learning to Dissect Fetal Pigs by Renée Nicole Macklin
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Kevin Stachelek @stchlk.bsky.social · 05/01/2026
being called “too clever by half”: 🧐
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Kevin Stachelek @stchlk.bsky.social · 01/01/2026
Thanks! Will likely stick with the first two. They’re pretty big. Especially on an e-reader. Love those covers, but that shrike is nowhere as terrifying as I picture.
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Kevin Stachelek @stchlk.bsky.social · 01/01/2026
Read recently, loved it, and was surprised I hadn’t heard of it earlier. Is it a good idea to read the follow-up?
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Timothy Burke @bubbaprog.xyz · 23/12/2025
The full spiked 60 Minutes CECOT package, clean & subtitled. 1/5
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Zahra Abbas @zahra-abbas.bsky.social · 22/12/2025
once again plugging this amazing resource for anyone in the paediatric cancer space. so much data, so easily accessible
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Kevin Stachelek @stchlk.bsky.social · 02/12/2025
How could I better understand this history?
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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
quinlanlab.org
Intro to Bedder – The Quinlan Lab
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Senator Chris Van Hollen @vanhollen.senate.gov · 27/11/2025
16-year-old American Mohammed Ibrahim has been released after over 9 months in an Israeli prison without trial. I was relieved to hear from his family today and to know that he’s safe and where he belongs — with his family.
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Alex Crits-Christoph @acritschristoph.bsky.social · 26/11/2025
This is a pretty useful page en.wikipedia.org/wiki/Wikiped...
en.wikipedia.org
Wikipedia:Signs of AI writing - Wikipedia
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Helena Lucia Crowell @helucro.bsky.social · 21/11/2025
Many people hours, calls and messages later: OSTA is now “in (pre)print”, though the real thing lives at bioconductor.org/books/OSTA. Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions). It’s been a joy working with you @estellayixingdong.bsky.social!
bioconductor.org
Orchestrating Spatial Transcriptomics Analysis with Bioconductor
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Chris Murphy @chrismurphyct.bsky.social · 20/11/2025
The President of the United States just called for Democratic members of Congress to be executed. "HANG THEM", he posted. If you're a person of influence in this country and you haven't picked a side, maybe now would be the time to pick a fucking side.
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Kevin Stachelek @stchlk.bsky.social · 24/10/2025
Was it the witch elm?
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Emil Hvitfeldt @emilhvitfeldt.bsky.social · 20/10/2025
Gave a talk about orbital last week at Socal RUG, it was delightful as always to spend time with these people. Slides: emilhvitfeldt.github.io/talk-orbital... Recording: www.youtube.com/live/pm-Ve3w...
screenshot of title slide. Reads "stop horsing around. ship the query! using orbital to run predictions in the database"
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Simon P. Couch @simonpcouch.com · 20/10/2025
I'll be keynoting at R/Pharma in a few weeks! The conference is free and virtual; all are welcome to join. My talk "Practical AI for data science" is on November 5th and should be broadly accessible for #rstats users, regardless of industry. :) Learn more & register: rinpharma.com
rinpharma.com
R/Pharma
The conference is a scientifically & industry oriented, collegial event focused on the use of R in the development of pharmaceuticals.
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Posit @posit.co · 20/10/2025
Announcing Plotnine 0.15.0: The Python package for Grammar of Graphics gets a massive upgrade! A new feature is Native Plot Composition: combine multiple independent plots into one figure, no more layout managers for multi-panel #Python graphs! Read the post: posit.co/blog/plotnin...
Four-panel chart grid: a) scatter plot of mpg vs. wt; b) box plot of mpg vs. cyl; c) line plot of mpg vs. disp; and d) bar chart of carb count.
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Open Bioinformatics Foundation @openbio.bsky.social · 30/09/2025
An open letter about the recent cuts at GigaScience: www.open-bio.org/2025/09/30/2... (open for signatures until the end of October) #OpenScience #OpenData #GigaScience
Scott Edmunds cuts the cake at the 2025 GigaScience birthday party at ISMB/ECCB 2025
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Kevin Stachelek @stchlk.bsky.social · 30/09/2025
rdcu.be/eITLE
rdcu.be
TEQUILA-seq: a versatile and low-cost method for targeted long-read RNA sequencing
Nature Communications - The authors report TEQUILA-seq, a versatile, easy-to-implement, and low-cost method for targeted long-read RNA sequencing. TEQUILA-seq uncovers transcript isoforms and RNA...
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Kevin Stachelek @stchlk.bsky.social · 07/09/2025
I ran NMF via github.com/MorrissyLab/... with scRNA-seq data. I don’t recall any installation struggles
github.com
GitHub - MorrissyLab/mosaicMPI: mosaicMPI: mosaic multi-resolution program integration
mosaicMPI: mosaic multi-resolution program integration - MorrissyLab/mosaicMPI
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Libby Heeren @libbyheeren.bsky.social · 04/09/2025
Ok, my buddies and I were ALL ABUZZ as we read about #nanonext last night 👀 Have you seen it?! Data exchange between R and Python made way more accessible? I have questions!! www.tidyverse.org/blog/2025/09... #databs #rstats #python
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Javier Santoyo @jsantoyo.bsky.social · 16/07/2025
Chevreul: an R bioconductor package for exploratory analysis of full-length single cell sequencing. #SingleCell #scRNAseq #FullLengthRNA #GigaByte gigabytejournal.com/articles/158
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Tina-Desiree Berg @tinadesireeberg.com · 04/07/2025
I contributed footage to this excellent visual investigation from @devonlum.bsky.social at the @nytimes.com www.nytimes.com/video/world/...
nytimes.com
Video: How Los Angeles Police Officers Broke Protocols and Injured Protesters
A Times analysis of videos and interviews with police, protesters and legal experts found that officers misused 40-mm sponge rounds at immigration-raid protests.
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Philipp Bayer @philippbayer.bsky.social · 04/06/2025
HIGHLY recommend reading this if you work in the intersection of AI and biology: rachel.fast.ai/posts/2025-0... then again, perhaps don't read it if you want that flashy Nature paper
rachel.fast.ai
Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored
an AI researcher going back to school for immunology
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Razzball @razzball.bsky.social · 01/06/2025
Ohtani bored watching Dodgers take BP vs the Yankees
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Alison Herman @aherman2006.bsky.social · 26/05/2025
I wrote about the finale of THE REHEARSAL s2: variety.com/2025/tv/revi...
variety.com
‘The Rehearsal’ Finale Reveals What Season 2 Was Really About — and It’s Not Just Planes: TV Review
In the Season 2 finale of his HBO series 'The Rehearsal', Nathan Fielder reveals what the aviation-centric season was really about.
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Eric Columbus @ericcolumbus.bsky.social · 09/05/2025
Just a reminder that Öztürk is in jail for writing this op-ed. That’s it. This is despicable. www.tuftsdaily.com/article/2024...
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Joshua J. Friedman @joshuajfriedman.com · 09/05/2025
Everyone loves describing their dissertation research to non-academics, right? Now try that on the witness stand in a second language on a Zoom connection from ICE custody!
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Childhood Cancer Data Lab @cancerdatalab.bsky.social · 27/03/2025
Hear from Drs. Eric Wafula and Elena Vasileva who sat down with us to share their experiences at Data Lab training workshops! Learn why they believe our #SingleCell #RNASeq courses are essential for #PediatricCancer researchers who want to perform their own analysis.
youtu.be
Accelerating Childhood Cancer Research through Data Science Training Workshops
YouTube video by Pediatric Oncology Knowledge Center
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