Nature Reviews Immunology, Published online: 19 August 2026; doi:10.1038/s41577-026-01349-4Inflammation seems to permeate many aspects of our lives, with the incidence of inflammatory diseases on the rise and ageing being blamed on it. Will the next 25 years see better ways to treat or prevent inflammation and allow us to live longer and healthier lives?

Dendritic cells (DCs) can acquire distinct functional states. To examine how different DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to label and ablate CCR7+ DCs and find that this activation state is essential for tumor control by uniquely priming tumor-specific cytotoxic T lymphocytes (CTLs), sustaining their function and enabling responses to immunotherapy.

Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options...

Microvillar contacts serve as sites of TCR and PD-1 signal integration, modulating T cell activation and tumor control.

Reducing or stopping immunosuppression in recipients of allografts has the potential to spare them from increased risk of infection, malignancy and cardiovascular events. Here, the authors report the ...

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

Past failures of T cell-based vaccines for chronic viral infection may reflect suboptimal induction of quality T cell responses. Here, the authors highlight the need to integrate diverse functional at...

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Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza traffics to the heart from the lung largely within pro-DC3s, which unleashes a damaging type I interferon program that compromises cardiac function.

Ramadan begins at sunset Feb. 17 and continues until Eid al-Fitr on March 19. This is the ninth and holiest month of the Islamic calendar, observed by Muslims around the world as 30-day period of fast...

Stuart K. Patrick Grant for Transplant Innovation at the University of Pittsburgh The Stuart K. Patrick Grant for Transplant Innovation at the University of Pittsburgh provides funding to faculty at t...

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Type-1 regulatory T cells (Tr1) promote immune tolerance during chronic infection, autoimmunity, and transplantation, but the role of Eomes in Tr1 differentiation and function after cell therapy is unclear. Zhang et al. find that Eomes controls the acquisition of regulatory and cytotoxic function in CD4+ T cells that are critical for limiting immune toxicity, while maintaining persistence and tumor control after immunotherapy.