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Sriram S

@srirams433.bsky.social
94 followers 228 following 30 posts

Post-doc in the Zuchero and Soltesz labs, Stanford Neurosurgery, studying neuron-oligodendrocyte interactions. Previously PhD in the Kolodkin lab @HopkinsNeuro

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Reposted by Sriram S
Vikram Chandra @vchandra.bsky.social · 09/09/2026
I am excited to announce that I will start the Brain Origins Lab at the Crick in March 2027! Using acoels as a model system, the lab will study how animal brains evolve, and how innovations in brain organisation enable new computational abilities and the evolution of complex behaviour.
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Bob Johnston @bobbyjeyeguy.bsky.social · 25/08/2026
Happy to share our review by Allie Reed from my lab together with Karina Chaudhari and Alex Kolodkin discussing the conservation of retinal direction-selective circuits across vertebrates! www.sciencedirect.com/science/arti...
sciencedirect.com
Conservation of retinal direction-selective circuits across vertebrate species
Retinal circuits extract visual features such as color, contrast, and motion. Direction-selective (DS) circuits provide a well-studied model for under…
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Sriram S @srirams433.bsky.social · 18/07/2026
#FluorescenceFriday Never let go: Oligodendrocyte (green) hold on to axon (magenta)
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Samantha Butler @samanthabutler.bsky.social · 10/07/2026
Looking for a great @cshlmeetings.bsky.social CSHL meeting this Fall? Abstract submission is open for "Molecular Mechanisms of Neuronal Connectivity" until July 22nd. Join me, @dacolon.bsky.social, Elva Diaz and @schuldinerorenlab.bsky.social at the bar! meetings.cshl.edu/meetings.asp...
meetings.cshl.edu
Molecular Mechanisms of Neuronal Connectivity
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Sriram S @srirams433.bsky.social · 10/06/2026
Great to see our review of axon branching in the cortex featured on the cover of this months issue of @cp-trendsneuro.bsky.social!
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Sriram S @srirams433.bsky.social · 11/04/2026
'Creation of Myelin': Oligodendrocyte (green) process reaches out and wraps around a neuronal axon (magenta) #FluorescenceFriday
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Robert Hill @bobalhill.bsky.social · 06/03/2026
Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 08/01/2026
Protein tyrosine phosphatase receptor type kappa (PTPRκ) regulates Superior ON-Direction Selective Ganglion Cell development, facilitating image stabilization www.biorxiv.org/content/10.64898/20…
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OneNeuro Initiative @oneneurojhu.org · 19/12/2025
The winner of OneNeuro's November #FotoFriday #FluorescenceFriday contest is "Portrait of a Claustrocortical Neuron" submitted by Baldomero B. Ramírez Cantú in the Solange Brown Lab at @hopkinsmedicine.bsky.social View the complete gallery of OneNeuro BRAINART images here: www.oneneurojhu.org/art/
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Sriram S @srirams433.bsky.social · 15/11/2025
Happy #FluorescenceFriday from this pair of white-matter oligodendrocytes!
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David Schoppik @schoppik.com · 02/11/2025
Thread coming soon, but be the first to read the latest from @franziau.bsky.social!
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Xiaoyun Ding @xyding.bsky.social · 22/10/2025
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me! Hope this tool helps more people see it too.
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Sriram S @srirams433.bsky.social · 04/10/2025
New cell-type for #FluorescenceFriday: astrocytes in the cerebral cortex
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Sriram S @srirams433.bsky.social · 19/09/2025
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
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Science Magazine @science.org · 12/09/2025
The hippocampus is one of the most studied brain areas because of its major role in fundamental brain functions including learning, memory, and spatial navigation. In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. scim.ag/3VKRbMM
(A) The canonical flow of information is outlined in gray, from the entorhinal cortex to DG granule cells (GCs), CA3, and then CA1 principal cells (PCs). PCs in noncanonical regions, which receive direct input from the hypothalamic supramammillary nucleus (SuM), are shown in green. (B) Large-amplitude events recorded from LFP in the DG hilus, known as dentate spikes, are associated with profound increases in brain-wide firing.
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Sriram S @srirams433.bsky.social · 19/08/2025
Delighted to share this work on intracortical arbor development and selective synaptogenesis by corticothalamic neurons. This was a really fun collaboration with Alan and the Brown lab during my PhD.
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Sangsoo Lee @sangsoolee.bsky.social · 10/08/2025
The Wu Lab at @JohnsHopkins is looking for a new postdoc fellow to study sleep and/or circadian-related behaviors in mice. If you're interested in, please contact us. www.markwulab.net
markwulab.net
Wu Lab
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SfN Journals @sfnjournals.bsky.social · 28/07/2025
#JNeurosci: @srirams433.bsky.social‬ Guzman-Clavel et al. uncover roles for Mef2c in cortical development: regulation of laminar subtype specification during embryogenesis & axon targeting in postnatal callosal neurons. @oneneuroinitiative.bsky.social doi.org/10.1523/JNEUROSCI.0201-25.2…
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Justus Kebschull @justuskebschull.bsky.social · 26/06/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Mapping the projectional architecture of the mouse midbrain dopaminergic system using cell type-specific barcoding
Brain-wide neural circuits are formed by the diverse axonal branching patterns of many individual neurons. Here we introduce POINTseq (projections of interest by sequencing), a high-throughput and use...
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stanfordbrain.bsky.social @stanfordbrain.bsky.social · 23/06/2025
Stanford research by Dr Barres changed our understanding of myelin—once seen as static insulation, now linked to learning & memory. Learn how @michellemonje.bsky.social, @erinmgibson.bsky.social, @bradzuchero.bsky.social & others continue to shape the field: neuroscience.stanford.edu/news/underst...
A dark ring of myelin in a black and white image of a cell. Image courtesy of Michelle Monje.Erin Gibson examines an electron microscope image of rings of myelin surrounding an axon. Michelle Monje’s lab has used electron microscopy to study rings of myelin surrounding an axon.Brad Zuchero (wearing a Ben Barres T-shirt) and Husniye Kantarci
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Sriram S @srirams433.bsky.social · 24/05/2025
Celebratory #FluorescenceFriday this week, with the JNeurosci cover featuring an image from our article on how Mef2c controls intracortical projection targeting
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OneNeuro Initiative @oneneurojhu.org · 02/05/2025
The winner of OneNeuro's April #FotoFriday #FluorescenceFriday contest was submitted by Luis Guzman-Clavel at the Alex Kolodkin Lab. For more information, see pubmed.ncbi.nlm.nih.gov/40228894/ View the complete gallery of OneNeuro BRAINART images here: www.oneneurojhu.org/art/
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Seth Blackshaw @sethblackshaw.bsky.social · 29/04/2025
Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1 www.biorxiv.org/content/10.1...
biorxiv.org
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.
Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the rod-dominant retinas of most mammals. The molecular mechani...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 16/04/2025
Our field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪
Our colleague Prof. Benny (Ben Zion) Shilo passed away this morning 
@WeizmannScience
 . Benny worked at the forefront of world science in the study of molecular and developmental genetics. Among other things, he won the A.M.T. Prize in the field of genetics in 2013. He was also a great explainer of science, a kind teacher - and an artist photographer with a sharp eye and a sensitive soul. Benny, we will miss you very much. May his memory be blessed.
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Mehmet Keles @flyman.bsky.social · 08/04/2025
I am proud to share that our work of 4+ years has finally been published. We wondered if there are distinct behaviors that mark sleep in 🪰, where sleep has been defined as prolonged immobility. 🔗 www.science.org/doi/10.1126/...
science.org
FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila
A machine learning platform identifies and characterizes the dynamics of microbehaviors during fly sleep.
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Sriram S @srirams433.bsky.social · 14/03/2025
Bittersweet #FluorescenceFriday saying goodbye to the Kolodkin lab with one last image, this time from the retinal side side of the lab. Here's a collection of retinorecipient targets in the mouse brain. How many of them can you name?
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Nicolas Renier @nicolasrenier.bsky.social · 07/02/2025
We're organizing the 4th iDISCO / TRISCO workshop at @rockefelleruniv.bsky.social in NYC! April 14-19 - FREE - registration to kavlifellows@mail.rockefeller.edu. Deadline: March 1st. We'll talk about brain mapping of cells, genes, axons, vasculature, light sheet microscopy, tissue clearing.
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Sriram S @srirams433.bsky.social · 01/02/2025
'From thought to action'... axons from the sensory cortex (green) arrive in the motor region to synapse with target neurons (yellow). Can't wait to get back to more imaging after weeks of thesis writing #FluorescenceFriday
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Sriram S @srirams433.bsky.social · 24/01/2025
Happy to share our pre-print, “ Mef2c controls postnatal callosal axon targeting by regulating sensitivity to Ephrin Repulsion”. We found that the topography of interhemispheric connectivity in the cerebral cortex is disrupted upon Mef2c deletion.(1/n)
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