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Mehmet Keles

@flyman.bsky.social
175 followers 393 following 10 posts

fly brain stuff. www.keleslab.com

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Reposted by Mehmet Keles
John Tuthill @tuthill.bsky.social · 30/06/2026
My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735
NBIO department logo
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Reposted by Mehmet Keles
Matteo Guardamagna @matteoguardamagna.bsky.social · 11/03/2026
1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵
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Reposted by Mehmet Keles
Giorgio Gilestro @giorgio.gilest.ro · 10/03/2026
Happy to announce I've launched a new service for the fly community: flyRoom, a web-based comprehensive stock manager for all your fly pushing needs. Organise all your stocks, maps all your genotypes, plan your crosses, print and scan your labels. Give it a try and let your colleagues know!
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Reposted by Mehmet Keles
Hannah Haberkern @hannah-haberkern.bsky.social · 23/12/2025
📢 Join us, the Haberkern lab, @uni-wuerzburg.de for a postdoc studying neural circuit mechanisms of navigation. You’ll spearheading neurophysiology experiments on our brand new 2P! ⏳ Apply by 28th February 2026 Details: www.haberkernlab.de/docs/ENPostd... #neuroscience #academicjobs #postdoc
On the left, the image shows a schematic of a fly head, ring neurons and EPG neurons together with some calcium imaging frames. On the right is a photo of a fly on a ball in virtual reality and another schematic of a VR system.
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Reposted by Mehmet Keles
Yvette Fisher @yvetteefisher.bsky.social · 15/12/2025
*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️
Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
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John Tuthill @tuthill.bsky.social · 09/12/2025
How do neural circuits generate the walking rhythm? Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg. w @bingbrunton.bsky.social www.biorxiv.org/content/10.1...
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Reposted by Mehmet Keles
The Transmitter @thetransmitter.bsky.social · 21/10/2025
There is still “an urgent need for donations from the community,” says Eric Lai, president of the Fly Board. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/community/fl...
thetransmitter.org
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
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Reposted by Mehmet Keles
Nature Neuroscience @natneuro.nature.com · 21/04/2025
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila 🧪🧠 www.nature.com/articles/s41...
nature.com
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila - Nature Neuroscience
Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with...
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Mehmet Keles @flyman.bsky.social · 08/04/2025
I am proud to share that our work of 4+ years has finally been published. We wondered if there are distinct behaviors that mark sleep in 🪰, where sleep has been defined as prolonged immobility. 🔗 www.science.org/doi/10.1126/...
science.org
FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila
A machine learning platform identifies and characterizes the dynamics of microbehaviors during fly sleep.
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