Sleep pressure, the accumulating drive towards sleep during wakefulness, is shaped by Lhx6-positive GABAergic neurons in the zona incerta (ZI). Here, we show that these neurons are broadly activated b...

This study identifies a sub-circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub-circuit is labeled by the clock output molecule mWAKE, which suppresse...

Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...