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Abandoning research participants is an unconscionable betrayal
In 1964, the Declaration of Helsinki created a set of universal ethical principles to protect human participants in health research.1 Described as “the cornerstone of research ethics,”2 these principles establish an overarching duty to safeguard the safety, dignity, and rights of people involved in medical research. In the United States this was followed, in 1979, by the Belmont Report, sub-titled “ Ethical Principles and Guidelines for the Protection of Human Subjects of Research.” 3 It set out three principles: respect for persons, and especially those with diminished autonomy; beneficence, maximising benefits and minimising harms; and justice, avoiding research conducted on groups who will not ultimately benefit from it. For poorer or otherwise vulnerable populations that have been historically mistreated, such protections are all the more critical.4 No research can be conducted ethically that lacks an absolute commitment to the wellbeing of participants.5
Sixty-one years later, the sudden cessation of multiple trials across the world threatens all of these duties at the foundation of research ethics. Specifically, by signing an executive order to freeze all foreign aid provided by the United States for at …