The Medical Research Council (MRC) has invested £50 million into the study of mitochondrial diseases to improve treatments.

Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle disease, delaying disease progression. Blocking local biosynthesis of serine challenges cellular phospholipid ho...

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...

Join us for an immersive week at the Mitochondria Summer School 2025, where leading experts and researchers will explore cutting-edge topics in mitochondrial biology!

We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...

Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Eating less, intermittent fasting, anti-ageing drugs such as rapamycin - there is a lot of public advice on preventing age-related diseases. A central regulator that appears to be linked to all these ...